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Gene: KLHL6 |
Gene summary for KLHL6 |
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Gene information | Species | Human | Gene symbol | KLHL6 | Gene ID | 89857 |
Gene name | kelch like family member 6 | |
Gene Alias | KLHL6 | |
Cytomap | 3q27.1 | |
Gene Type | protein-coding | GO ID | GO:0002250 | UniProtAcc | Q8WZ60 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89857 | KLHL6 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 4.05e-03 | 5.97e-01 | 0.1479 |
89857 | KLHL6 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 7.42e-03 | 6.31e-01 | 0.1531 |
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Tissue | Expression Dynamics | Abbreviation |
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL6 | SNV | Missense_Mutation | rs535540527 | c.821C>T | p.Thr274Met | p.T274M | Q8WZ60 | protein_coding | deleterious(0.03) | possibly_damaging(0.831) | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
KLHL6 | SNV | Missense_Mutation | c.955N>A | p.Glu319Lys | p.E319K | Q8WZ60 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KLHL6 | SNV | Missense_Mutation | rs372412048 | c.983N>T | p.Thr328Met | p.T328M | Q8WZ60 | protein_coding | deleterious(0.02) | possibly_damaging(0.899) | TCGA-OL-A66J-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KLHL6 | insertion | Frame_Shift_Ins | novel | c.749_750insGGAGGCAGAGGTTGTAGTGAGCCGAGATCACGCC | p.Leu251GlufsTer64 | p.L251Efs*64 | Q8WZ60 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KLHL6 | SNV | Missense_Mutation | c.1324G>A | p.Asp442Asn | p.D442N | Q8WZ60 | protein_coding | tolerated(0.06) | probably_damaging(0.954) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
KLHL6 | SNV | Missense_Mutation | rs376100820 | c.25N>A | p.Ala9Thr | p.A9T | Q8WZ60 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-EA-A1QT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KLHL6 | SNV | Missense_Mutation | c.197N>A | p.Arg66Gln | p.R66Q | Q8WZ60 | protein_coding | deleterious(0.03) | possibly_damaging(0.821) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
KLHL6 | SNV | Missense_Mutation | rs757111409 | c.467N>A | p.Arg156Gln | p.R156Q | Q8WZ60 | protein_coding | tolerated(0.59) | possibly_damaging(0.625) | TCGA-MA-AA3Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KLHL6 | SNV | Missense_Mutation | c.1696N>T | p.Arg566Trp | p.R566W | Q8WZ60 | protein_coding | deleterious(0) | probably_damaging(0.909) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLHL6 | SNV | Missense_Mutation | c.885G>T | p.Arg295Ser | p.R295S | Q8WZ60 | protein_coding | deleterious(0.02) | benign(0.191) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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