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Gene: KIAA1549 |
Gene summary for KIAA1549 |
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Gene information | Species | Human | Gene symbol | KIAA1549 | Gene ID | 57670 |
Gene name | KIAA1549 | |
Gene Alias | RP86 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9HCM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57670 | KIAA1549 | HCC1_Meng | Human | Liver | HCC | 1.53e-17 | 4.38e-02 | 0.0246 |
57670 | KIAA1549 | HCC1 | Human | Liver | HCC | 6.66e-05 | 1.97e+00 | 0.5336 |
57670 | KIAA1549 | HCC2 | Human | Liver | HCC | 1.86e-08 | 1.05e+00 | 0.5341 |
57670 | KIAA1549 | HCC5 | Human | Liver | HCC | 1.27e-04 | 5.05e-01 | 0.4932 |
57670 | KIAA1549 | S027 | Human | Liver | HCC | 1.34e-07 | 3.49e-01 | 0.2446 |
57670 | KIAA1549 | S028 | Human | Liver | HCC | 1.70e-09 | 2.56e-01 | 0.2503 |
57670 | KIAA1549 | S029 | Human | Liver | HCC | 2.88e-02 | 2.01e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1549 | SNV | Missense_Mutation | novel | c.4108N>T | p.Ile1370Phe | p.I1370F | Q9HCM3 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
KIAA1549 | SNV | Missense_Mutation | novel | c.5734N>G | p.Thr1912Ala | p.T1912A | Q9HCM3 | protein_coding | tolerated(0.1) | benign(0.006) | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
KIAA1549 | SNV | Missense_Mutation | novel | c.2641N>G | p.Thr881Ala | p.T881A | Q9HCM3 | protein_coding | tolerated(0.29) | benign(0) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
KIAA1549 | SNV | Missense_Mutation | novel | c.3483N>A | p.Asn1161Lys | p.N1161K | Q9HCM3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A7-A6VY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
KIAA1549 | SNV | Missense_Mutation | c.3831A>T | p.Gln1277His | p.Q1277H | Q9HCM3 | protein_coding | deleterious(0.04) | benign(0.437) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
KIAA1549 | SNV | Missense_Mutation | c.208N>G | p.His70Asp | p.H70D | Q9HCM3 | protein_coding | deleterious_low_confidence(0) | benign(0.08) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIAA1549 | SNV | Missense_Mutation | rs777901817 | c.1757C>T | p.Pro586Leu | p.P586L | Q9HCM3 | protein_coding | deleterious(0.05) | benign(0.085) | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
KIAA1549 | SNV | Missense_Mutation | novel | c.548N>T | p.Pro183Leu | p.P183L | Q9HCM3 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A8FY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA1549 | SNV | Missense_Mutation | c.3244N>T | p.His1082Tyr | p.H1082Y | Q9HCM3 | protein_coding | deleterious(0.02) | benign(0.158) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | |
KIAA1549 | insertion | Frame_Shift_Ins | novel | c.5735_5736insATTCTTCCTCCTTCTTCTGGTGCTA | p.Ser1913PhefsTer114 | p.S1913Ffs*114 | Q9HCM3 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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