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Gene: IQCE |
Gene summary for IQCE |
Gene summary. |
Gene information | Species | Human | Gene symbol | IQCE | Gene ID | 23288 |
Gene name | IQ motif containing E | |
Gene Alias | 1700028P05Rik | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | A0A087WX45 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23288 | IQCE | LZE22T | Human | Esophagus | ESCC | 4.30e-02 | 2.30e-01 | 0.068 |
23288 | IQCE | LZE24T | Human | Esophagus | ESCC | 4.01e-02 | 1.13e-01 | 0.0596 |
23288 | IQCE | P1T-E | Human | Esophagus | ESCC | 3.67e-04 | 2.37e-01 | 0.0875 |
23288 | IQCE | P2T-E | Human | Esophagus | ESCC | 1.57e-17 | 3.72e-01 | 0.1177 |
23288 | IQCE | P4T-E | Human | Esophagus | ESCC | 2.27e-06 | 1.00e-01 | 0.1323 |
23288 | IQCE | P8T-E | Human | Esophagus | ESCC | 5.85e-07 | 1.27e-01 | 0.0889 |
23288 | IQCE | P10T-E | Human | Esophagus | ESCC | 6.41e-04 | 1.20e-01 | 0.116 |
23288 | IQCE | P11T-E | Human | Esophagus | ESCC | 2.20e-04 | 2.72e-01 | 0.1426 |
23288 | IQCE | P12T-E | Human | Esophagus | ESCC | 1.46e-09 | 9.28e-02 | 0.1122 |
23288 | IQCE | P15T-E | Human | Esophagus | ESCC | 1.83e-10 | 1.64e-01 | 0.1149 |
23288 | IQCE | P16T-E | Human | Esophagus | ESCC | 4.60e-11 | 2.15e-01 | 0.1153 |
23288 | IQCE | P19T-E | Human | Esophagus | ESCC | 1.10e-03 | 2.92e-01 | 0.1662 |
23288 | IQCE | P20T-E | Human | Esophagus | ESCC | 1.28e-08 | 1.18e-01 | 0.1124 |
23288 | IQCE | P21T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.46e-01 | 0.1617 |
23288 | IQCE | P22T-E | Human | Esophagus | ESCC | 1.22e-09 | 1.84e-01 | 0.1236 |
23288 | IQCE | P23T-E | Human | Esophagus | ESCC | 5.87e-06 | 1.42e-01 | 0.108 |
23288 | IQCE | P26T-E | Human | Esophagus | ESCC | 7.58e-07 | 1.48e-01 | 0.1276 |
23288 | IQCE | P27T-E | Human | Esophagus | ESCC | 5.14e-09 | 2.27e-01 | 0.1055 |
23288 | IQCE | P28T-E | Human | Esophagus | ESCC | 7.28e-09 | 1.49e-01 | 0.1149 |
23288 | IQCE | P30T-E | Human | Esophagus | ESCC | 1.37e-04 | 1.94e-01 | 0.137 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | |
Breast | IDC | |
Breast | DCIS | |
Cervix | CC | |
Cervix | HSIL_HPV |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487367 | Esophagus | ESCC | appendage development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
GO:00601737 | Esophagus | ESCC | limb development | 98/8552 | 172/18723 | 1.83e-03 | 8.37e-03 | 98 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IQCE | SNV | Missense_Mutation | rs555990190 | c.506N>T | p.Thr169Met | p.T169M | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AR-A5QQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
IQCE | insertion | Frame_Shift_Ins | novel | c.1906_1907insAAATTACT | p.Arg636LysfsTer40 | p.R636Kfs*40 | protein_coding | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
IQCE | insertion | Frame_Shift_Ins | novel | c.1907_1908insAGGCTGCTGTAAACCTCAGA | p.Arg637GlyfsTer43 | p.R637Gfs*43 | protein_coding | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
IQCE | insertion | Frame_Shift_Ins | novel | c.283_284insG | p.Ser95CysfsTer18 | p.S95Cfs*18 | protein_coding | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |||
IQCE | insertion | Nonsense_Mutation | novel | c.284_285insAGTGGAACCAGATCTGGACCCCGTTCTGTGAGATCTGG | p.Pro96ValfsTer10 | p.P96Vfs*10 | protein_coding | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |||
IQCE | insertion | Frame_Shift_Ins | novel | c.1108_1109insACAGGAGGGAAGATGTGCAGAGTCGTTTGAGTCC | p.Ala370AspfsTer122 | p.A370Dfs*122 | protein_coding | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |||
IQCE | SNV | Missense_Mutation | novel | c.501N>A | p.Met167Ile | p.M167I | protein_coding | deleterious(0) | possibly_damaging(0.611) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
IQCE | SNV | Missense_Mutation | rs775017409 | c.363N>C | p.Lys121Asn | p.K121N | protein_coding | deleterious(0) | possibly_damaging(0.802) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
IQCE | SNV | Missense_Mutation | rs779690833 | c.1217C>T | p.Ala406Val | p.A406V | protein_coding | deleterious(0.05) | benign(0.03) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IQCE | SNV | Missense_Mutation | novel | c.1621N>A | p.Val541Ile | p.V541I | protein_coding | tolerated(0.16) | benign(0.071) | TCGA-AA-3860-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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