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Gene: HIST1H2BJ |
Gene summary for HIST1H2BJ |
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Gene information | Species | Human | Gene symbol | HIST1H2BJ | Gene ID | 8970 |
Gene name | H2B clustered histone 11 | |
Gene Alias | H2B/r | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | GO:0001906 | UniProtAcc | A0A024RCJ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8970 | HIST1H2BJ | CCI_2 | Human | Cervix | CC | 1.21e-16 | 9.66e-01 | 0.5249 |
8970 | HIST1H2BJ | CCI_3 | Human | Cervix | CC | 3.04e-05 | 2.06e-01 | 0.516 |
8970 | HIST1H2BJ | Tumor | Human | Cervix | CC | 9.00e-07 | 1.88e-01 | 0.1241 |
8970 | HIST1H2BJ | sample3 | Human | Cervix | CC | 8.77e-10 | 1.41e-01 | 0.1387 |
8970 | HIST1H2BJ | T3 | Human | Cervix | CC | 1.81e-04 | 1.33e-01 | 0.1389 |
8970 | HIST1H2BJ | LZE4T | Human | Esophagus | ESCC | 6.07e-05 | 4.33e-01 | 0.0811 |
8970 | HIST1H2BJ | LZE7T | Human | Esophagus | ESCC | 4.04e-05 | 3.35e-01 | 0.0667 |
8970 | HIST1H2BJ | LZE20T | Human | Esophagus | ESCC | 2.68e-08 | 3.16e-01 | 0.0662 |
8970 | HIST1H2BJ | LZE21D1 | Human | Esophagus | HGIN | 1.61e-02 | 3.14e-01 | 0.0632 |
8970 | HIST1H2BJ | LZE22T | Human | Esophagus | ESCC | 6.11e-09 | 7.61e-01 | 0.068 |
8970 | HIST1H2BJ | LZE24T | Human | Esophagus | ESCC | 3.98e-04 | 3.13e-01 | 0.0596 |
8970 | HIST1H2BJ | LZE21T | Human | Esophagus | ESCC | 3.77e-05 | 9.27e-01 | 0.0655 |
8970 | HIST1H2BJ | P1T-E | Human | Esophagus | ESCC | 2.29e-23 | 1.50e+00 | 0.0875 |
8970 | HIST1H2BJ | P2T-E | Human | Esophagus | ESCC | 4.16e-22 | 4.53e-01 | 0.1177 |
8970 | HIST1H2BJ | P4T-E | Human | Esophagus | ESCC | 9.90e-16 | 5.28e-01 | 0.1323 |
8970 | HIST1H2BJ | P5T-E | Human | Esophagus | ESCC | 4.27e-02 | 1.10e-01 | 0.1327 |
8970 | HIST1H2BJ | P8T-E | Human | Esophagus | ESCC | 4.87e-07 | 2.14e-01 | 0.0889 |
8970 | HIST1H2BJ | P9T-E | Human | Esophagus | ESCC | 3.04e-10 | 4.36e-01 | 0.1131 |
8970 | HIST1H2BJ | P10T-E | Human | Esophagus | ESCC | 2.08e-17 | 4.94e-01 | 0.116 |
8970 | HIST1H2BJ | P11T-E | Human | Esophagus | ESCC | 5.52e-06 | 3.99e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H2BJ | SNV | Missense_Mutation | c.178N>C | p.Met60Leu | p.M60L | P06899 | protein_coding | deleterious_low_confidence(0.01) | benign(0.039) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD | |
HIST1H2BJ | insertion | Frame_Shift_Ins | novel | c.18_19insCACGCCGTGTCCGAGGG | p.Ser7HisfsTer19 | p.S7Hfs*19 | P06899 | protein_coding | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
HIST1H2BJ | SNV | Missense_Mutation | c.340N>A | p.Glu114Lys | p.E114K | P06899 | protein_coding | tolerated_low_confidence(0.07) | benign(0.124) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HIST1H2BJ | SNV | Missense_Mutation | c.80N>T | p.Gly27Val | p.G27V | P06899 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.821) | TCGA-F4-6461-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
HIST1H2BJ | SNV | Missense_Mutation | novel | c.116N>A | p.Ser39Tyr | p.S39Y | P06899 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.781) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
HIST1H2BJ | SNV | Missense_Mutation | c.48N>T | p.Lys16Asn | p.K16N | P06899 | protein_coding | deleterious_low_confidence(0.01) | benign(0.217) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
HIST1H2BJ | SNV | Missense_Mutation | c.144N>C | p.Gln48His | p.Q48H | P06899 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.968) | TCGA-50-6591-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
HIST1H2BJ | SNV | Missense_Mutation | novel | c.278N>C | p.Arg93Thr | p.R93T | P06899 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.982) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H2BJ | SNV | Missense_Mutation | c.10N>A | p.Pro4Thr | p.P4T | P06899 | protein_coding | tolerated_low_confidence(0.17) | benign(0) | TCGA-CV-6436-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HIST1H2BJ | SNV | Missense_Mutation | novel | c.310N>T | p.Pro104Ser | p.P104S | P06899 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.99) | TCGA-WA-A7GZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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