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Gene: HCP5 |
Gene summary for HCP5 |
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Gene information | Species | Human | Gene symbol | HCP5 | Gene ID | 10866 |
Gene name | HLA complex P5 | |
Gene Alias | 6S2650E | |
Cytomap | 6p21.33 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10866 | HCP5 | CCI_1 | Human | Cervix | CC | 1.43e-02 | 1.93e-01 | 0.528 |
10866 | HCP5 | CCI_2 | Human | Cervix | CC | 2.23e-25 | 1.21e+00 | 0.5249 |
10866 | HCP5 | CCI_3 | Human | Cervix | CC | 1.65e-18 | 5.69e-01 | 0.516 |
10866 | HCP5 | sample1 | Human | Cervix | CC | 7.04e-14 | 4.93e-01 | 0.0959 |
10866 | HCP5 | sample3 | Human | Cervix | CC | 1.08e-20 | 2.82e-01 | 0.1387 |
10866 | HCP5 | H2 | Human | Cervix | HSIL_HPV | 1.61e-02 | 1.25e-01 | 0.0632 |
10866 | HCP5 | T1 | Human | Cervix | CC | 6.54e-29 | 5.49e-01 | 0.0918 |
10866 | HCP5 | T3 | Human | Cervix | CC | 2.32e-16 | 2.60e-01 | 0.1389 |
10866 | HCP5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.54e-08 | 2.03e-01 | 0.0155 |
10866 | HCP5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.88e-04 | 1.53e-01 | -0.1808 |
10866 | HCP5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.43e-08 | 2.76e-01 | -0.0811 |
10866 | HCP5 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.48e-07 | 2.49e-01 | -0.1088 |
10866 | HCP5 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.42e-16 | 3.20e-01 | -0.1954 |
10866 | HCP5 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.78e-05 | 4.38e-01 | -0.2602 |
10866 | HCP5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.57e-06 | 2.02e-01 | -0.1207 |
10866 | HCP5 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.64e-05 | 2.18e-01 | -0.1526 |
10866 | HCP5 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.44e-19 | 3.92e-01 | -0.1464 |
10866 | HCP5 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.32e-10 | 2.13e-01 | -0.1001 |
10866 | HCP5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.65e-10 | 2.74e-01 | -0.059 |
10866 | HCP5 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.29e-03 | 2.63e-01 | -0.1706 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10866 | HCP5 | NA | gemcitabine | GEMCITABINE | 31616045 | |
10866 | HCP5 | NA | carboplatin | CARBOPLATIN | 31616045 | |
10866 | HCP5 | NA | nevirapine | NEVIRAPINE | 24322967 |
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