![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GLIS1 |
Gene summary for GLIS1 |
![]() |
Gene information | Species | Human | Gene symbol | GLIS1 | Gene ID | 148979 |
Gene name | GLIS family zinc finger 1 | |
Gene Alias | GLIS1 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8NBF1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148979 | GLIS1 | C30 | Human | Oral cavity | OSCC | 5.10e-11 | 6.74e-01 | 0.3055 |
148979 | GLIS1 | C51 | Human | Oral cavity | OSCC | 1.10e-19 | 1.20e+00 | 0.2674 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLIS1 | SNV | Missense_Mutation | novel | c.723N>T | p.Lys241Asn | p.K241N | Q8NBF1 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-A8-A090-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLIS1 | SNV | Missense_Mutation | novel | c.1755G>T | p.Gln585His | p.Q585H | Q8NBF1 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.846) | TCGA-AC-A23G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
GLIS1 | SNV | Missense_Mutation | rs755556848 | c.1742C>T | p.Ala581Val | p.A581V | Q8NBF1 | protein_coding | tolerated_low_confidence(0.2) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GLIS1 | SNV | Missense_Mutation | novel | c.384N>A | p.Asp128Glu | p.D128E | Q8NBF1 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-E2-A1B5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
GLIS1 | SNV | Missense_Mutation | novel | c.961C>T | p.Pro321Ser | p.P321S | Q8NBF1 | protein_coding | deleterious(0) | benign(0.318) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GLIS1 | SNV | Missense_Mutation | rs747562057 | c.821N>T | p.Ser274Leu | p.S274L | Q8NBF1 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
GLIS1 | SNV | Missense_Mutation | c.1650N>G | p.Phe550Leu | p.F550L | Q8NBF1 | protein_coding | deleterious(0.04) | benign(0.444) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GLIS1 | SNV | Missense_Mutation | rs555262672 | c.1342N>A | p.Glu448Lys | p.E448K | Q8NBF1 | protein_coding | deleterious(0.02) | possibly_damaging(0.549) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
GLIS1 | SNV | Missense_Mutation | c.670N>A | p.Arg224Ser | p.R224S | Q8NBF1 | protein_coding | deleterious(0.01) | benign(0.234) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GLIS1 | SNV | Missense_Mutation | novel | c.302T>C | p.Val101Ala | p.V101A | Q8NBF1 | protein_coding | deleterious(0) | benign(0.005) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |