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Gene: GARS1-DT |
Gene summary for GARS1-DT |
Gene summary. |
Gene information | Species | Human | Gene symbol | GARS1-DT | Gene ID | 401320 |
Gene name | GARS1 divergent transcript | |
Gene Alias | GARS-DT | |
Cytomap | 7p14.3 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401320 | GARS1-DT | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.08e-08 | 1.98e-01 | 0.0155 |
401320 | GARS1-DT | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.60e-12 | 3.40e-01 | -0.1808 |
401320 | GARS1-DT | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.43e-08 | 3.09e-01 | -0.0811 |
401320 | GARS1-DT | HTA11_78_2000001011 | Human | Colorectum | AD | 7.82e-22 | 4.30e-01 | -0.1088 |
401320 | GARS1-DT | HTA11_347_2000001011 | Human | Colorectum | AD | 1.64e-34 | 5.68e-01 | -0.1954 |
401320 | GARS1-DT | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 4.38e-01 | -0.2602 |
401320 | GARS1-DT | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.91e-05 | 2.02e-01 | -0.1207 |
401320 | GARS1-DT | HTA11_83_2000001011 | Human | Colorectum | SER | 1.12e-08 | 2.97e-01 | -0.1526 |
401320 | GARS1-DT | HTA11_696_2000001011 | Human | Colorectum | AD | 3.31e-19 | 3.61e-01 | -0.1464 |
401320 | GARS1-DT | HTA11_866_2000001011 | Human | Colorectum | AD | 7.82e-13 | 2.97e-01 | -0.1001 |
401320 | GARS1-DT | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.86e-09 | 2.44e-01 | -0.059 |
401320 | GARS1-DT | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.72e-05 | 3.33e-01 | -0.1706 |
401320 | GARS1-DT | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-03 | 3.08e-01 | -0.1462 |
401320 | GARS1-DT | HTA11_546_2000001011 | Human | Colorectum | AD | 2.65e-04 | 1.99e-01 | -0.0842 |
401320 | GARS1-DT | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.79e-05 | 2.70e-01 | -0.0179 |
401320 | GARS1-DT | HTA11_866_3004761011 | Human | Colorectum | AD | 2.04e-08 | 2.06e-01 | 0.096 |
401320 | GARS1-DT | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.52e-01 | 0.0446 |
401320 | GARS1-DT | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.37e-05 | 3.27e-01 | 0.0528 |
401320 | GARS1-DT | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.58e-09 | 4.07e-01 | 0.0131 |
401320 | GARS1-DT | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.04e-05 | 2.81e-01 | -0.0177 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | |
Breast | IDC | |
Breast | DCIS | |
Cervix | CC | |
Cervix | HSIL_HPV |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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