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Gene: FAM210B |
Gene summary for FAM210B |
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Gene information | Species | Human | Gene symbol | FAM210B | Gene ID | 116151 |
Gene name | family with sequence similarity 210 member B | |
Gene Alias | 5A3 | |
Cytomap | 20q13.2 | |
Gene Type | protein-coding | GO ID | GO:0002262 | UniProtAcc | Q96KR6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116151 | FAM210B | GSM4909281 | Human | Breast | IDC | 8.09e-04 | 2.91e-01 | 0.21 |
116151 | FAM210B | GSM4909282 | Human | Breast | IDC | 1.29e-10 | 3.81e-01 | -0.0288 |
116151 | FAM210B | GSM4909286 | Human | Breast | IDC | 1.13e-04 | 3.02e-01 | 0.1081 |
116151 | FAM210B | GSM4909296 | Human | Breast | IDC | 4.38e-03 | -7.38e-02 | 0.1524 |
116151 | FAM210B | GSM4909298 | Human | Breast | IDC | 3.51e-10 | 4.44e-01 | 0.1551 |
116151 | FAM210B | GSM4909301 | Human | Breast | IDC | 2.58e-09 | 5.13e-01 | 0.1577 |
116151 | FAM210B | GSM4909304 | Human | Breast | IDC | 1.04e-10 | 4.43e-01 | 0.1636 |
116151 | FAM210B | GSM4909311 | Human | Breast | IDC | 3.34e-09 | -1.13e-01 | 0.1534 |
116151 | FAM210B | GSM4909317 | Human | Breast | IDC | 3.86e-72 | 1.22e+00 | 0.1355 |
116151 | FAM210B | GSM4909318 | Human | Breast | IDC | 5.11e-31 | 1.34e+00 | 0.2031 |
116151 | FAM210B | GSM4909319 | Human | Breast | IDC | 5.09e-12 | -8.70e-02 | 0.1563 |
116151 | FAM210B | GSM4909321 | Human | Breast | IDC | 9.18e-04 | 2.84e-02 | 0.1559 |
116151 | FAM210B | NCCBC14 | Human | Breast | DCIS | 3.06e-04 | -5.25e-04 | 0.2021 |
116151 | FAM210B | NCCBC2 | Human | Breast | DCIS | 2.42e-03 | 3.94e-01 | 0.1554 |
116151 | FAM210B | NCCBC5 | Human | Breast | DCIS | 7.22e-03 | -4.10e-02 | 0.2046 |
116151 | FAM210B | P1 | Human | Breast | IDC | 6.93e-07 | 6.49e-03 | 0.1527 |
116151 | FAM210B | DCIS2 | Human | Breast | DCIS | 2.19e-61 | 3.94e-01 | 0.0085 |
116151 | FAM210B | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.78e-02 | 1.78e-01 | -0.1808 |
116151 | FAM210B | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.69e-08 | 3.53e-01 | -0.0811 |
116151 | FAM210B | HTA11_78_2000001011 | Human | Colorectum | AD | 1.37e-09 | 3.24e-01 | -0.1088 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003410114 | Breast | IDC | erythrocyte homeostasis | 27/1434 | 129/18723 | 1.34e-06 | 5.75e-05 | 27 |
GO:000226214 | Breast | IDC | myeloid cell homeostasis | 30/1434 | 157/18723 | 2.64e-06 | 1.01e-04 | 30 |
GO:003235512 | Breast | IDC | response to estradiol | 27/1434 | 141/18723 | 7.87e-06 | 2.35e-04 | 27 |
GO:003009914 | Breast | IDC | myeloid cell differentiation | 54/1434 | 381/18723 | 8.07e-06 | 2.39e-04 | 54 |
GO:190370612 | Breast | IDC | regulation of hemopoiesis | 49/1434 | 367/18723 | 9.74e-05 | 1.86e-03 | 49 |
GO:003021814 | Breast | IDC | erythrocyte differentiation | 22/1434 | 120/18723 | 1.04e-04 | 1.97e-03 | 22 |
GO:004563714 | Breast | IDC | regulation of myeloid cell differentiation | 32/1434 | 210/18723 | 1.41e-04 | 2.50e-03 | 32 |
GO:004564613 | Breast | IDC | regulation of erythrocyte differentiation | 12/1434 | 47/18723 | 1.63e-04 | 2.78e-03 | 12 |
GO:004563912 | Breast | IDC | positive regulation of myeloid cell differentiation | 18/1434 | 103/18723 | 7.77e-04 | 9.37e-03 | 18 |
GO:004887214 | Breast | IDC | homeostasis of number of cells | 36/1434 | 272/18723 | 9.10e-04 | 1.04e-02 | 36 |
GO:0045648 | Breast | IDC | positive regulation of erythrocyte differentiation | 8/1434 | 33/18723 | 2.85e-03 | 2.49e-02 | 8 |
GO:003410124 | Breast | DCIS | erythrocyte homeostasis | 27/1390 | 129/18723 | 7.31e-07 | 3.06e-05 | 27 |
GO:000226224 | Breast | DCIS | myeloid cell homeostasis | 30/1390 | 157/18723 | 1.39e-06 | 5.33e-05 | 30 |
GO:003009924 | Breast | DCIS | myeloid cell differentiation | 55/1390 | 381/18723 | 1.50e-06 | 5.68e-05 | 55 |
GO:004563722 | Breast | DCIS | regulation of myeloid cell differentiation | 34/1390 | 210/18723 | 1.33e-05 | 3.32e-04 | 34 |
GO:003235521 | Breast | DCIS | response to estradiol | 26/1390 | 141/18723 | 1.34e-05 | 3.33e-04 | 26 |
GO:190370622 | Breast | DCIS | regulation of hemopoiesis | 50/1390 | 367/18723 | 2.21e-05 | 5.23e-04 | 50 |
GO:003021823 | Breast | DCIS | erythrocyte differentiation | 22/1390 | 120/18723 | 6.60e-05 | 1.31e-03 | 22 |
GO:004564621 | Breast | DCIS | regulation of erythrocyte differentiation | 12/1390 | 47/18723 | 1.22e-04 | 2.11e-03 | 12 |
GO:004563921 | Breast | DCIS | positive regulation of myeloid cell differentiation | 19/1390 | 103/18723 | 1.86e-04 | 3.03e-03 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM210B | SNV | Missense_Mutation | c.342A>G | p.Ile114Met | p.I114M | Q96KR6 | protein_coding | tolerated(0.26) | benign(0.125) | TCGA-AC-A3TN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
FAM210B | SNV | Missense_Mutation | c.491G>C | p.Arg164Thr | p.R164T | Q96KR6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
FAM210B | SNV | Missense_Mutation | novel | c.235G>A | p.Glu79Lys | p.E79K | Q96KR6 | protein_coding | tolerated(0.27) | benign(0.01) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
FAM210B | SNV | Missense_Mutation | rs201707629 | c.415N>T | p.Val139Leu | p.V139L | Q96KR6 | protein_coding | tolerated(0.31) | benign(0.115) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM210B | insertion | Frame_Shift_Ins | novel | c.274_275insT | p.Gln94SerfsTer42 | p.Q94Sfs*42 | Q96KR6 | protein_coding | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | ||
FAM210B | insertion | Frame_Shift_Ins | novel | c.362_362+1insTGGTGTGGACATGCCT | p.Ala127TrpfsTer14 | p.A127Wfs*14 | Q96KR6 | protein_coding | TCGA-22-5492-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
FAM210B | SNV | Missense_Mutation | rs534520658 | c.451N>A | p.Val151Met | p.V151M | Q96KR6 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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