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Gene: EFCAB1 |
Gene summary for EFCAB1 |
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Gene information | Species | Human | Gene symbol | EFCAB1 | Gene ID | 79645 |
Gene name | EF-hand calcium binding domain 1 | |
Gene Alias | EFCAB1 | |
Cytomap | 8q11.21 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024R7U7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79645 | EFCAB1 | P2T-E | Human | Esophagus | ESCC | 6.62e-20 | 4.00e-01 | 0.1177 |
79645 | EFCAB1 | P10T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.18e-01 | 0.116 |
79645 | EFCAB1 | P16T-E | Human | Esophagus | ESCC | 6.36e-33 | 5.87e-01 | 0.1153 |
79645 | EFCAB1 | P21T-E | Human | Esophagus | ESCC | 2.39e-24 | 4.76e-01 | 0.1617 |
79645 | EFCAB1 | P31T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.26e-01 | 0.1251 |
79645 | EFCAB1 | P32T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.01e-01 | 0.1666 |
79645 | EFCAB1 | P37T-E | Human | Esophagus | ESCC | 1.24e-04 | 1.42e-01 | 0.1371 |
79645 | EFCAB1 | P38T-E | Human | Esophagus | ESCC | 3.67e-05 | 2.18e-01 | 0.127 |
79645 | EFCAB1 | P56T-E | Human | Esophagus | ESCC | 1.26e-12 | 1.02e+00 | 0.1613 |
79645 | EFCAB1 | P57T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.06e-01 | 0.0926 |
79645 | EFCAB1 | P74T-E | Human | Esophagus | ESCC | 1.26e-08 | 2.46e-01 | 0.1479 |
79645 | EFCAB1 | P79T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.93e-01 | 0.1154 |
79645 | EFCAB1 | P83T-E | Human | Esophagus | ESCC | 2.62e-07 | 2.13e-01 | 0.1738 |
79645 | EFCAB1 | P89T-E | Human | Esophagus | ESCC | 6.02e-08 | 4.13e-01 | 0.1752 |
79645 | EFCAB1 | P107T-E | Human | Esophagus | ESCC | 2.64e-07 | 2.03e-01 | 0.171 |
79645 | EFCAB1 | P130T-E | Human | Esophagus | ESCC | 1.49e-39 | 6.90e-01 | 0.1676 |
79645 | EFCAB1 | C04 | Human | Oral cavity | OSCC | 6.29e-03 | 2.63e-01 | 0.2633 |
79645 | EFCAB1 | C30 | Human | Oral cavity | OSCC | 1.22e-20 | 8.67e-01 | 0.3055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EFCAB1 | SNV | Missense_Mutation | c.379C>T | p.His127Tyr | p.H127Y | Q9HAE3 | protein_coding | tolerated(0.48) | benign(0.133) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
EFCAB1 | SNV | Missense_Mutation | novel | c.154N>A | p.Ala52Thr | p.A52T | Q9HAE3 | protein_coding | tolerated(0.81) | benign(0) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EFCAB1 | SNV | Missense_Mutation | c.442G>T | p.Asp148Tyr | p.D148Y | Q9HAE3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
EFCAB1 | SNV | Missense_Mutation | novel | c.497N>A | p.Ser166Tyr | p.S166Y | Q9HAE3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
EFCAB1 | SNV | Missense_Mutation | c.443N>T | p.Asp148Val | p.D148V | Q9HAE3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CK-4950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folfox | SD | |
EFCAB1 | SNV | Missense_Mutation | c.478N>T | p.Asp160Tyr | p.D160Y | Q9HAE3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-3893-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR | |
EFCAB1 | SNV | Missense_Mutation | novel | c.505N>T | p.Asp169Tyr | p.D169Y | Q9HAE3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EFCAB1 | SNV | Missense_Mutation | c.430G>A | p.Glu144Lys | p.E144K | Q9HAE3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DC-6683-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
EFCAB1 | SNV | Missense_Mutation | c.479N>G | p.Asp160Gly | p.D160G | Q9HAE3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EFCAB1 | SNV | Missense_Mutation | novel | c.457A>G | p.Thr153Ala | p.T153A | Q9HAE3 | protein_coding | tolerated(0.67) | benign(0.078) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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