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Gene: DHX40 |
Gene summary for DHX40 |
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Gene information | Species | Human | Gene symbol | DHX40 | Gene ID | 79665 |
Gene name | DEAH-box helicase 40 | |
Gene Alias | ARG147 | |
Cytomap | 17q23.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B4DR88 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79665 | DHX40 | LZE4T | Human | Esophagus | ESCC | 1.11e-08 | 1.71e-01 | 0.0811 |
79665 | DHX40 | LZE7T | Human | Esophagus | ESCC | 4.96e-07 | 4.64e-01 | 0.0667 |
79665 | DHX40 | LZE20T | Human | Esophagus | ESCC | 3.76e-04 | 2.54e-02 | 0.0662 |
79665 | DHX40 | LZE24T | Human | Esophagus | ESCC | 2.29e-14 | 4.12e-01 | 0.0596 |
79665 | DHX40 | P1T-E | Human | Esophagus | ESCC | 1.25e-04 | 1.85e-01 | 0.0875 |
79665 | DHX40 | P2T-E | Human | Esophagus | ESCC | 2.83e-24 | 2.31e-01 | 0.1177 |
79665 | DHX40 | P4T-E | Human | Esophagus | ESCC | 2.94e-07 | 6.85e-02 | 0.1323 |
79665 | DHX40 | P5T-E | Human | Esophagus | ESCC | 3.79e-06 | -4.78e-02 | 0.1327 |
79665 | DHX40 | P8T-E | Human | Esophagus | ESCC | 6.40e-19 | 3.49e-01 | 0.0889 |
79665 | DHX40 | P10T-E | Human | Esophagus | ESCC | 3.62e-14 | 1.65e-01 | 0.116 |
79665 | DHX40 | P11T-E | Human | Esophagus | ESCC | 3.42e-07 | 2.35e-01 | 0.1426 |
79665 | DHX40 | P12T-E | Human | Esophagus | ESCC | 2.28e-14 | 1.61e-01 | 0.1122 |
79665 | DHX40 | P15T-E | Human | Esophagus | ESCC | 1.18e-12 | 1.72e-01 | 0.1149 |
79665 | DHX40 | P16T-E | Human | Esophagus | ESCC | 2.16e-17 | 2.18e-01 | 0.1153 |
79665 | DHX40 | P19T-E | Human | Esophagus | ESCC | 1.59e-02 | 1.22e-01 | 0.1662 |
79665 | DHX40 | P20T-E | Human | Esophagus | ESCC | 3.42e-03 | 1.10e-01 | 0.1124 |
79665 | DHX40 | P21T-E | Human | Esophagus | ESCC | 2.71e-09 | 1.35e-01 | 0.1617 |
79665 | DHX40 | P22T-E | Human | Esophagus | ESCC | 3.47e-16 | 8.20e-02 | 0.1236 |
79665 | DHX40 | P23T-E | Human | Esophagus | ESCC | 7.05e-20 | 5.60e-01 | 0.108 |
79665 | DHX40 | P24T-E | Human | Esophagus | ESCC | 9.40e-15 | 1.36e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DHX40 | SNV | Missense_Mutation | novel | c.526N>A | p.His176Asn | p.H176N | Q8IX18 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
DHX40 | SNV | Missense_Mutation | c.1151N>T | p.Pro384Leu | p.P384L | Q8IX18 | protein_coding | deleterious(0) | possibly_damaging(0.574) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DHX40 | SNV | Missense_Mutation | c.1996N>C | p.Glu666Gln | p.E666Q | Q8IX18 | protein_coding | deleterious(0.04) | possibly_damaging(0.892) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DHX40 | SNV | Missense_Mutation | novel | c.1622G>A | p.Arg541Gln | p.R541Q | Q8IX18 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-AC-A62V-01 | Breast | breast invasive carcinoma | Male | <65 | III/IV | Targeted Molecular therapy | denosumab | PD |
DHX40 | SNV | Missense_Mutation | c.2068G>C | p.Glu690Gln | p.E690Q | Q8IX18 | protein_coding | tolerated(0.2) | possibly_damaging(0.796) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DHX40 | SNV | Missense_Mutation | c.971C>T | p.Thr324Ile | p.T324I | Q8IX18 | protein_coding | deleterious(0) | possibly_damaging(0.796) | TCGA-E9-A1R3-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | methotrexate | SD | |
DHX40 | SNV | Missense_Mutation | novel | c.380G>A | p.Gly127Glu | p.G127E | Q8IX18 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
DHX40 | SNV | Missense_Mutation | novel | c.76N>A | p.Glu26Lys | p.E26K | Q8IX18 | protein_coding | tolerated(0.65) | benign(0.099) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DHX40 | SNV | Missense_Mutation | c.2315N>A | p.Ser772Asn | p.S772N | Q8IX18 | protein_coding | tolerated_low_confidence(0.11) | benign(0.055) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DHX40 | SNV | Missense_Mutation | novel | c.1070T>C | p.Ile357Thr | p.I357T | Q8IX18 | protein_coding | deleterious(0) | possibly_damaging(0.654) | TCGA-AA-3941-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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