GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:190332216 | Esophagus | ESCC | positive regulation of protein modification by small protein conjugation or removal | 99/8552 | 138/18723 | 4.39e-10 | 1.16e-08 | 99 |
GO:003139816 | Esophagus | ESCC | positive regulation of protein ubiquitination | 82/8552 | 119/18723 | 2.41e-07 | 3.64e-06 | 82 |
GO:005143819 | Esophagus | ESCC | regulation of ubiquitin-protein transferase activity | 38/8552 | 53/18723 | 1.10e-04 | 7.69e-04 | 38 |
GO:004511614 | Esophagus | ESCC | protein neddylation | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:00514433 | Esophagus | ESCC | positive regulation of ubiquitin-protein transferase activity | 21/8552 | 31/18723 | 1.10e-02 | 3.70e-02 | 21 |
GO:19033207 | Liver | NAFLD | regulation of protein modification by small protein conjugation or removal | 44/1882 | 242/18723 | 7.53e-05 | 1.56e-03 | 44 |
GO:00313967 | Liver | NAFLD | regulation of protein ubiquitination | 38/1882 | 210/18723 | 2.49e-04 | 4.12e-03 | 38 |
GO:00514384 | Liver | NAFLD | regulation of ubiquitin-protein transferase activity | 14/1882 | 53/18723 | 5.66e-04 | 7.59e-03 | 14 |
GO:190332022 | Liver | HCC | regulation of protein modification by small protein conjugation or removal | 167/7958 | 242/18723 | 4.99e-17 | 4.72e-15 | 167 |
GO:003139622 | Liver | HCC | regulation of protein ubiquitination | 142/7958 | 210/18723 | 1.39e-13 | 7.81e-12 | 142 |
GO:19033221 | Liver | HCC | positive regulation of protein modification by small protein conjugation or removal | 94/7958 | 138/18723 | 9.87e-10 | 3.01e-08 | 94 |
GO:00313981 | Liver | HCC | positive regulation of protein ubiquitination | 79/7958 | 119/18723 | 1.18e-07 | 2.26e-06 | 79 |
GO:005143821 | Liver | HCC | regulation of ubiquitin-protein transferase activity | 36/7958 | 53/18723 | 1.62e-04 | 1.29e-03 | 36 |
GO:00451161 | Liver | HCC | protein neddylation | 15/7958 | 18/18723 | 4.74e-04 | 3.12e-03 | 15 |
GO:0051443 | Liver | HCC | positive regulation of ubiquitin-protein transferase activity | 21/7958 | 31/18723 | 4.01e-03 | 1.76e-02 | 21 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCUN1D4 | SNV | Missense_Mutation | | c.170N>C | p.Asn57Thr | p.N57T | Q92564 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.954) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DCUN1D4 | SNV | Missense_Mutation | | c.520N>A | p.Glu174Lys | p.E174K | Q92564 | protein_coding | tolerated(0.11) | benign(0.109) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DCUN1D4 | SNV | Missense_Mutation | | c.846N>G | p.Phe282Leu | p.F282L | Q92564 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
DCUN1D4 | SNV | Missense_Mutation | novel | c.374N>T | p.Arg125Ile | p.R125I | Q92564 | protein_coding | deleterious(0) | possibly_damaging(0.482) | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DCUN1D4 | deletion | Frame_Shift_Del | novel | c.493_500delGGCCCTGA | p.Gly165ArgfsTer7 | p.G165Rfs*7 | Q92564 | protein_coding | | | TCGA-A7-A4SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
DCUN1D4 | insertion | Nonsense_Mutation | novel | c.499_500insTCACTTAATCTCTCTGCTTTGGTTTCCCTGTTTGTCAAAATATGAT | p.Glu167ValfsTer3 | p.E167Vfs*3 | Q92564 | protein_coding | | | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
DCUN1D4 | insertion | Nonsense_Mutation | novel | c.372_373insGTCACTTAATCTCTCTGCTTTGGTTTCCCTGTTTGTCAAAATATG | p.Ser124_Arg125insValThrTerSerLeuCysPheGlyPheProValCysGlnAsnMet | p.S124_R125insVT*SLCFGFPVCQNM | Q92564 | protein_coding | | | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DCUN1D4 | deletion | Frame_Shift_Del | novel | c.739delN | p.Phe247LeufsTer10 | p.F247Lfs*10 | Q92564 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
DCUN1D4 | SNV | Missense_Mutation | rs745489867 | c.925N>T | p.Asp309Tyr | p.D309Y | Q92564 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DCUN1D4 | SNV | Missense_Mutation | | c.566N>T | p.Ala189Val | p.A189V | Q92564 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |