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Gene: CRACD |
Gene summary for CRACD |
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Gene information | Species | Human | Gene symbol | CRACD | Gene ID | 57482 |
Gene name | capping protein inhibiting regulator of actin dynamics | |
Gene Alias | CRAD | |
Cytomap | 4q12 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q6ZU35 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57482 | CRACD | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.35e-15 | 3.11e-01 | 0.0155 |
57482 | CRACD | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.30e-29 | 8.34e-01 | -0.1808 |
57482 | CRACD | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.03e-06 | 4.41e-01 | 0.0216 |
57482 | CRACD | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.85e-11 | 3.82e-01 | -0.0811 |
57482 | CRACD | HTA11_78_2000001011 | Human | Colorectum | AD | 4.35e-37 | 8.24e-01 | -0.1088 |
57482 | CRACD | HTA11_347_2000001011 | Human | Colorectum | AD | 1.60e-52 | 1.06e+00 | -0.1954 |
57482 | CRACD | HTA11_411_2000001011 | Human | Colorectum | SER | 2.50e-11 | 1.37e+00 | -0.2602 |
57482 | CRACD | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.67e-17 | 1.00e+00 | -0.2196 |
57482 | CRACD | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.01e-23 | 6.31e-01 | -0.1207 |
57482 | CRACD | HTA11_83_2000001011 | Human | Colorectum | SER | 2.68e-22 | 6.46e-01 | -0.1526 |
57482 | CRACD | HTA11_696_2000001011 | Human | Colorectum | AD | 4.02e-55 | 1.04e+00 | -0.1464 |
57482 | CRACD | HTA11_866_2000001011 | Human | Colorectum | AD | 3.91e-47 | 8.43e-01 | -0.1001 |
57482 | CRACD | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.29e-47 | 1.00e+00 | -0.059 |
57482 | CRACD | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.79e-16 | 8.16e-01 | -0.1706 |
57482 | CRACD | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.61e-16 | 6.02e-01 | -0.2061 |
57482 | CRACD | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.36e-01 | -0.1462 |
57482 | CRACD | HTA11_546_2000001011 | Human | Colorectum | AD | 6.64e-16 | 6.71e-01 | -0.0842 |
57482 | CRACD | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.78e-05 | 4.72e-01 | -0.00410000000000005 |
57482 | CRACD | HTA11_866_3004761011 | Human | Colorectum | AD | 4.40e-16 | 3.45e-01 | 0.096 |
57482 | CRACD | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.22e-05 | 4.15e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0030838 | Colorectum | AD | positive regulation of actin filament polymerization | 48/3918 | 99/18723 | 9.21e-10 | 7.03e-08 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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