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Gene: CNPY3 |
Gene summary for CNPY3 |
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Gene information | Species | Human | Gene symbol | CNPY3 | Gene ID | 10695 |
Gene name | canopy FGF signaling regulator 3 | |
Gene Alias | CAG4A | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9BT09 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10695 | CNPY3 | LZE2T | Human | Esophagus | ESCC | 1.48e-12 | 2.53e+00 | 0.082 |
10695 | CNPY3 | LZE4T | Human | Esophagus | ESCC | 1.19e-19 | 6.09e-01 | 0.0811 |
10695 | CNPY3 | LZE5T | Human | Esophagus | ESCC | 3.45e-02 | 4.75e-01 | 0.0514 |
10695 | CNPY3 | LZE7T | Human | Esophagus | ESCC | 3.39e-08 | 6.55e-01 | 0.0667 |
10695 | CNPY3 | LZE8T | Human | Esophagus | ESCC | 2.46e-09 | 2.97e-01 | 0.067 |
10695 | CNPY3 | LZE20T | Human | Esophagus | ESCC | 1.50e-07 | 5.26e-01 | 0.0662 |
10695 | CNPY3 | LZE22D1 | Human | Esophagus | HGIN | 1.27e-08 | 2.71e-01 | 0.0595 |
10695 | CNPY3 | LZE22T | Human | Esophagus | ESCC | 6.47e-11 | 1.01e+00 | 0.068 |
10695 | CNPY3 | LZE24T | Human | Esophagus | ESCC | 4.23e-25 | 8.09e-01 | 0.0596 |
10695 | CNPY3 | LZE22D3 | Human | Esophagus | HGIN | 3.11e-02 | 4.97e-01 | 0.0653 |
10695 | CNPY3 | LZE21T | Human | Esophagus | ESCC | 3.94e-04 | 8.45e-01 | 0.0655 |
10695 | CNPY3 | LZE6T | Human | Esophagus | ESCC | 9.47e-13 | 1.00e+00 | 0.0845 |
10695 | CNPY3 | P1T-E | Human | Esophagus | ESCC | 2.33e-13 | 8.01e-01 | 0.0875 |
10695 | CNPY3 | P2T-E | Human | Esophagus | ESCC | 7.10e-37 | 7.44e-01 | 0.1177 |
10695 | CNPY3 | P4T-E | Human | Esophagus | ESCC | 3.18e-37 | 1.19e+00 | 0.1323 |
10695 | CNPY3 | P5T-E | Human | Esophagus | ESCC | 1.01e-24 | 4.62e-01 | 0.1327 |
10695 | CNPY3 | P8T-E | Human | Esophagus | ESCC | 3.19e-48 | 8.61e-01 | 0.0889 |
10695 | CNPY3 | P9T-E | Human | Esophagus | ESCC | 8.67e-35 | 8.34e-01 | 0.1131 |
10695 | CNPY3 | P10T-E | Human | Esophagus | ESCC | 2.34e-54 | 8.82e-01 | 0.116 |
10695 | CNPY3 | P11T-E | Human | Esophagus | ESCC | 1.95e-28 | 1.47e+00 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNPY3 | SNV | Missense_Mutation | rs371606876 | c.712N>A | p.Gly238Ser | p.G238S | Q9BT09 | protein_coding | tolerated(0.36) | benign(0) | TCGA-AC-A2QH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
CNPY3 | SNV | Missense_Mutation | c.667N>C | p.Gly223Arg | p.G223R | Q9BT09 | protein_coding | tolerated(0.23) | benign(0.11) | TCGA-AR-A1AQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CNPY3 | insertion | Frame_Shift_Ins | novel | c.255_256insA | p.Gly86ArgfsTer16 | p.G86Rfs*16 | Q9BT09 | protein_coding | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CNPY3 | insertion | In_Frame_Ins | novel | c.257_258insATTTCTATTTTATCT | p.Gly86_Val87insPheLeuPheTyrLeu | p.G86_V87insFLFYL | Q9BT09 | protein_coding | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CNPY3 | SNV | Missense_Mutation | c.619N>A | p.Leu207Met | p.L207M | Q9BT09 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
CNPY3 | SNV | Missense_Mutation | novel | c.622N>A | p.Ala208Thr | p.A208T | Q9BT09 | protein_coding | tolerated(0.59) | benign(0.005) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CNPY3 | SNV | Missense_Mutation | novel | c.712N>T | p.Gly238Cys | p.G238C | Q9BT09 | protein_coding | deleterious(0.01) | benign(0.189) | TCGA-DM-A288-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
CNPY3 | insertion | Frame_Shift_Ins | novel | c.818_819insC | p.Asp276Ter | p.D276* | Q9BT09 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CNPY3 | SNV | Missense_Mutation | rs755208427 | c.224C>T | p.Thr75Met | p.T75M | Q9BT09 | protein_coding | tolerated(0.19) | probably_damaging(0.993) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CNPY3 | SNV | Missense_Mutation | rs746471637 | c.292N>A | p.Glu98Lys | p.E98K | Q9BT09 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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