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Gene: CLDND2 |
Gene summary for CLDND2 |
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Gene information | Species | Human | Gene symbol | CLDND2 | Gene ID | 125875 |
Gene name | claudin domain containing 2 | |
Gene Alias | CLDND2 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8NHS1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
125875 | CLDND2 | HCC1_Meng | Human | Liver | HCC | 2.06e-34 | 2.55e-02 | 0.0246 |
125875 | CLDND2 | cirrhotic1 | Human | Liver | Cirrhotic | 1.47e-03 | 6.16e-02 | 0.0202 |
125875 | CLDND2 | S027 | Human | Liver | HCC | 1.36e-03 | 5.31e-01 | 0.2446 |
125875 | CLDND2 | S028 | Human | Liver | HCC | 3.91e-02 | 2.69e-01 | 0.2503 |
125875 | CLDND2 | S029 | Human | Liver | HCC | 1.10e-09 | 5.34e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLDND2 | SNV | Missense_Mutation | novel | c.5N>T | p.Gly2Val | p.G2V | Q8NHS1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
CLDND2 | SNV | Missense_Mutation | rs199591571 | c.98N>A | p.Arg33His | p.R33H | Q8NHS1 | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLDND2 | SNV | Missense_Mutation | c.424C>A | p.Leu142Ile | p.L142I | Q8NHS1 | protein_coding | tolerated(0.13) | benign(0.066) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLDND2 | SNV | Missense_Mutation | novel | c.333G>C | p.Leu111Phe | p.L111F | Q8NHS1 | protein_coding | deleterious(0.03) | benign(0.017) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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