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Gene: CDC42SE2 |
Gene summary for CDC42SE2 |
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Gene information | Species | Human | Gene symbol | CDC42SE2 | Gene ID | 56990 |
Gene name | CDC42 small effector 2 | |
Gene Alias | SPEC2 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9NRR3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56990 | CDC42SE2 | CA_HPV_1 | Human | Cervix | CC | 2.98e-06 | 3.20e-01 | 0.0264 |
56990 | CDC42SE2 | CCI_2 | Human | Cervix | CC | 3.61e-02 | 7.80e-01 | 0.5249 |
56990 | CDC42SE2 | CCI_3 | Human | Cervix | CC | 4.73e-02 | 5.59e-01 | 0.516 |
56990 | CDC42SE2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.20e-16 | -5.83e-01 | 0.0155 |
56990 | CDC42SE2 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.16e-18 | 7.30e-01 | -0.1954 |
56990 | CDC42SE2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.91e-07 | -4.75e-01 | 0.096 |
56990 | CDC42SE2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 4.35e-02 | -6.90e-01 | 0.0451 |
56990 | CDC42SE2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.18e-06 | -3.87e-01 | 0.0674 |
56990 | CDC42SE2 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.97e-03 | -5.23e-01 | 0.0397 |
56990 | CDC42SE2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.83e-03 | -4.82e-01 | 0.0588 |
56990 | CDC42SE2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.34e-04 | 6.91e-01 | 0.3487 |
56990 | CDC42SE2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.48e-03 | -5.72e-01 | 0.2585 |
56990 | CDC42SE2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.12e-21 | -6.17e-01 | 0.3005 |
56990 | CDC42SE2 | F007 | Human | Colorectum | FAP | 1.24e-09 | -6.02e-01 | 0.1176 |
56990 | CDC42SE2 | A002-C-010 | Human | Colorectum | FAP | 4.11e-04 | -2.87e-01 | 0.242 |
56990 | CDC42SE2 | A001-C-207 | Human | Colorectum | FAP | 1.81e-07 | -4.42e-01 | 0.1278 |
56990 | CDC42SE2 | A015-C-203 | Human | Colorectum | FAP | 4.23e-41 | -5.86e-01 | -0.1294 |
56990 | CDC42SE2 | A015-C-204 | Human | Colorectum | FAP | 2.50e-09 | -4.44e-01 | -0.0228 |
56990 | CDC42SE2 | A014-C-040 | Human | Colorectum | FAP | 4.34e-07 | -5.68e-01 | -0.1184 |
56990 | CDC42SE2 | A002-C-201 | Human | Colorectum | FAP | 9.43e-23 | -5.98e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00072666 | Cervix | CC | Rho protein signal transduction | 35/2311 | 137/18723 | 1.77e-05 | 3.33e-04 | 35 |
GO:00083608 | Cervix | CC | regulation of cell shape | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00465785 | Cervix | CC | regulation of Ras protein signal transduction | 44/2311 | 189/18723 | 2.05e-05 | 3.73e-04 | 44 |
GO:00350235 | Cervix | CC | regulation of Rho protein signal transduction | 22/2311 | 86/18723 | 5.93e-04 | 5.60e-03 | 22 |
GO:0006909 | Cervix | CC | phagocytosis | 53/2311 | 308/18723 | 7.49e-03 | 4.01e-02 | 53 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:0007266 | Colorectum | AD | Rho protein signal transduction | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:00226042 | Colorectum | MSS | regulation of cell morphogenesis | 103/3467 | 309/18723 | 2.70e-10 | 2.56e-08 | 103 |
GO:00083602 | Colorectum | MSS | regulation of cell shape | 52/3467 | 154/18723 | 4.40e-06 | 1.24e-04 | 52 |
GO:00072651 | Colorectum | MSS | Ras protein signal transduction | 91/3467 | 337/18723 | 7.20e-05 | 1.21e-03 | 91 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
GO:00226043 | Colorectum | MSI-H | regulation of cell morphogenesis | 45/1319 | 309/18723 | 2.70e-06 | 1.54e-04 | 45 |
GO:00226044 | Colorectum | FAP | regulation of cell morphogenesis | 87/2622 | 309/18723 | 4.89e-11 | 1.87e-08 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDC42SE2 | deletion | Frame_Shift_Del | novel | c.118delN | p.His40MetfsTer11 | p.H40Mfs*11 | Q9NRR3 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CDC42SE2 | SNV | Missense_Mutation | rs373834432 | c.242N>T | p.Thr81Met | p.T81M | Q9NRR3 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.791) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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