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Gene: CCNDBP1 |
Gene summary for CCNDBP1 |
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Gene information | Species | Human | Gene symbol | CCNDBP1 | Gene ID | 23582 |
Gene name | cyclin D1 binding protein 1 | |
Gene Alias | DIP1 | |
Cytomap | 15q15.2 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | O95273 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23582 | CCNDBP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.59e-05 | 3.55e-01 | -0.0811 |
23582 | CCNDBP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.32e-02 | 2.48e-01 | -0.1088 |
23582 | CCNDBP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.33e-12 | 3.70e-01 | -0.1954 |
23582 | CCNDBP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.03e-06 | 7.71e-01 | -0.2602 |
23582 | CCNDBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.64e-03 | 1.94e-01 | -0.1464 |
23582 | CCNDBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.16e-05 | 2.63e-01 | 0.096 |
23582 | CCNDBP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 5.75e-03 | 3.74e-01 | 0.0131 |
23582 | CCNDBP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.27e-02 | 1.74e-01 | 0.0674 |
23582 | CCNDBP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.14e-03 | 2.65e-01 | 0.0588 |
23582 | CCNDBP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.74e-10 | 3.16e-01 | 0.294 |
23582 | CCNDBP1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.43e-07 | 1.18e+00 | 0.3487 |
23582 | CCNDBP1 | LZE2T | Human | Esophagus | ESCC | 3.12e-06 | 2.97e-01 | 0.082 |
23582 | CCNDBP1 | LZE4T | Human | Esophagus | ESCC | 2.98e-14 | 5.41e-01 | 0.0811 |
23582 | CCNDBP1 | LZE5T | Human | Esophagus | ESCC | 3.49e-05 | 1.12e-01 | 0.0514 |
23582 | CCNDBP1 | LZE7T | Human | Esophagus | ESCC | 2.50e-05 | 5.30e-01 | 0.0667 |
23582 | CCNDBP1 | LZE8T | Human | Esophagus | ESCC | 4.97e-13 | 2.84e-01 | 0.067 |
23582 | CCNDBP1 | LZE20T | Human | Esophagus | ESCC | 9.37e-08 | 2.12e-01 | 0.0662 |
23582 | CCNDBP1 | LZE22D1 | Human | Esophagus | HGIN | 4.04e-06 | 1.40e-01 | 0.0595 |
23582 | CCNDBP1 | LZE22T | Human | Esophagus | ESCC | 3.35e-02 | 4.61e-01 | 0.068 |
23582 | CCNDBP1 | LZE24T | Human | Esophagus | ESCC | 5.55e-23 | 7.75e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCNDBP1 | SNV | Missense_Mutation | c.958G>A | p.Glu320Lys | p.E320K | O95273 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCNDBP1 | SNV | Missense_Mutation | c.268N>A | p.Glu90Lys | p.E90K | O95273 | protein_coding | deleterious(0.01) | possibly_damaging(0.559) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
CCNDBP1 | deletion | Frame_Shift_Del | novel | c.467delN | p.Val157LeufsTer19 | p.V157Lfs*19 | O95273 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CCNDBP1 | SNV | Missense_Mutation | novel | c.559N>T | p.Ala187Ser | p.A187S | O95273 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A8EC-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
CCNDBP1 | SNV | Missense_Mutation | novel | c.281N>G | p.Ala94Gly | p.A94G | O95273 | protein_coding | tolerated(0.36) | benign(0.098) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CCNDBP1 | SNV | Missense_Mutation | rs776264677 | c.914N>A | p.Arg305Gln | p.R305Q | O95273 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CCNDBP1 | SNV | Missense_Mutation | c.353N>C | p.Val118Ala | p.V118A | O95273 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CCNDBP1 | SNV | Missense_Mutation | rs776264677 | c.914N>A | p.Arg305Gln | p.R305Q | O95273 | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CCNDBP1 | SNV | Missense_Mutation | c.431N>T | p.Pro144Leu | p.P144L | O95273 | protein_coding | tolerated(0.28) | benign(0.005) | TCGA-DC-6682-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CCNDBP1 | SNV | Missense_Mutation | novel | c.622N>T | p.Thr208Ser | p.T208S | O95273 | protein_coding | tolerated(1) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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