|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: CCDC200 |
Gene summary for CCDC200 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CCDC200 | Gene ID | 100874261 |
| Gene name | coiled-coil domain containing 200 | |
| Gene Alias | LINC00854 | |
| Cytomap | 17q21.31 | |
| Gene Type | protein-coding | GO ID | NA | UniProtAcc | NA |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100874261 | CCDC200 | CCI_1 | Human | Cervix | CC | 1.49e-06 | 5.99e-01 | 0.528 |
| 100874261 | CCDC200 | CCI_2 | Human | Cervix | CC | 2.86e-05 | 3.17e-01 | 0.5249 |
| 100874261 | CCDC200 | CCI_3 | Human | Cervix | CC | 1.78e-36 | 1.39e+00 | 0.516 |
| 100874261 | CCDC200 | CCII_1 | Human | Cervix | CC | 4.46e-06 | 2.22e-01 | 0.3249 |
| 100874261 | CCDC200 | RNA-P17T-P17T-2 | Human | Lung | IAC | 6.80e-05 | 7.72e-01 | 0.3371 |
| 100874261 | CCDC200 | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.71e-02 | 5.81e-01 | 0.343 |
| 100874261 | CCDC200 | RNA-P17T-P17T-6 | Human | Lung | IAC | 4.28e-05 | 8.31e-01 | 0.3385 |
| 100874261 | CCDC200 | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.77e-07 | 8.44e-01 | 0.3329 |
| 100874261 | CCDC200 | HTA12-23-1 | Human | Pancreas | PDAC | 3.41e-03 | 3.67e-01 | 0.3405 |
| 100874261 | CCDC200 | HTA12-25-1 | Human | Pancreas | PDAC | 3.52e-06 | 6.61e-01 | 0.313 |
| 100874261 | CCDC200 | HTA12-26-1 | Human | Pancreas | PDAC | 8.44e-11 | 6.78e-01 | 0.3728 |
| 100874261 | CCDC200 | HTA12-29-1 | Human | Pancreas | PDAC | 7.36e-14 | 3.90e-01 | 0.3722 |
| 100874261 | CCDC200 | HTA12-30-1 | Human | Pancreas | PDAC | 6.56e-10 | 1.53e+00 | 0.3671 |
| 100874261 | CCDC200 | HTA12-32-1 | Human | Pancreas | PDAC | 1.46e-03 | 8.56e-01 | 0.3624 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Breast | Precancer |  |
| Breast | IDC |  |
| Breast | DCIS |  |
| Cervix | CC |  |
| Cervix | HSIL_HPV |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |