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Gene: C9orf16 |
Gene summary for C9ORF16 |
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Gene information | Species | Human | Gene symbol | C9orf16 | Gene ID | 79095 |
Gene name | bublin coiled coil protein | |
Gene Alias | C9orf16 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9BUW7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79095 | C9orf16 | GSM4909286 | Human | Breast | IDC | 1.28e-06 | 2.71e-01 | 0.1081 |
79095 | C9orf16 | GSM4909287 | Human | Breast | IDC | 1.70e-05 | -1.87e-01 | 0.2057 |
79095 | C9orf16 | GSM4909288 | Human | Breast | IDC | 1.32e-04 | 5.06e-02 | 0.0988 |
79095 | C9orf16 | GSM4909293 | Human | Breast | IDC | 2.89e-02 | -1.14e-01 | 0.1581 |
79095 | C9orf16 | GSM4909294 | Human | Breast | IDC | 1.86e-21 | 3.95e-01 | 0.2022 |
79095 | C9orf16 | GSM4909296 | Human | Breast | IDC | 1.29e-10 | -1.80e-01 | 0.1524 |
79095 | C9orf16 | GSM4909297 | Human | Breast | IDC | 8.99e-32 | -5.48e-01 | 0.1517 |
79095 | C9orf16 | GSM4909298 | Human | Breast | IDC | 1.42e-05 | -2.67e-01 | 0.1551 |
79095 | C9orf16 | GSM4909301 | Human | Breast | IDC | 6.25e-05 | -2.84e-01 | 0.1577 |
79095 | C9orf16 | GSM4909302 | Human | Breast | IDC | 1.42e-04 | -1.93e-01 | 0.1545 |
79095 | C9orf16 | GSM4909309 | Human | Breast | IDC | 6.46e-04 | -1.48e-01 | 0.0483 |
79095 | C9orf16 | GSM4909311 | Human | Breast | IDC | 5.71e-44 | -3.53e-01 | 0.1534 |
79095 | C9orf16 | GSM4909312 | Human | Breast | IDC | 7.01e-17 | -3.07e-01 | 0.1552 |
79095 | C9orf16 | GSM4909313 | Human | Breast | IDC | 3.63e-05 | -9.12e-02 | 0.0391 |
79095 | C9orf16 | GSM4909316 | Human | Breast | IDC | 1.79e-07 | -1.52e-01 | 0.21 |
79095 | C9orf16 | GSM4909319 | Human | Breast | IDC | 1.10e-53 | -5.27e-01 | 0.1563 |
79095 | C9orf16 | GSM4909320 | Human | Breast | IDC | 4.23e-09 | -4.17e-01 | 0.1575 |
79095 | C9orf16 | GSM4909321 | Human | Breast | IDC | 1.11e-24 | -4.33e-01 | 0.1559 |
79095 | C9orf16 | ctrl6 | Human | Breast | Precancer | 2.02e-05 | -4.10e-01 | -0.0061 |
79095 | C9orf16 | brca3 | Human | Breast | Precancer | 1.06e-05 | -3.00e-01 | -0.0263 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C9orf16 | SNV | Missense_Mutation | c.210N>A | p.Phe70Leu | p.F70L | Q9BUW7 | protein_coding | tolerated(0.15) | possibly_damaging(0.77) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
C9orf16 | SNV | Missense_Mutation | novel | c.163C>A | p.Arg55Ser | p.R55S | Q9BUW7 | protein_coding | tolerated(0.07) | benign(0.297) | TCGA-55-6972-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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