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Gene: C4orf36 |
Gene summary for C4ORF36 |
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Gene information | Species | Human | Gene symbol | C4orf36 | Gene ID | 132989 |
Gene name | chromosome 4 open reading frame 36 | |
Gene Alias | C4orf36 | |
Cytomap | 4q21.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96KX1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
132989 | C4orf36 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.05e-03 | 1.65e-01 | 0.0155 |
132989 | C4orf36 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.06e-08 | 3.10e-01 | -0.1808 |
132989 | C4orf36 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.97e-05 | 2.84e-01 | -0.0811 |
132989 | C4orf36 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.67e-07 | 3.18e-01 | -0.1088 |
132989 | C4orf36 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.16e-18 | 4.80e-01 | -0.1954 |
132989 | C4orf36 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.74e-04 | 2.95e-01 | -0.1207 |
132989 | C4orf36 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.55e-05 | 3.45e-01 | -0.1526 |
132989 | C4orf36 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.50e-14 | 3.40e-01 | -0.1464 |
132989 | C4orf36 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.86e-14 | 3.87e-01 | -0.1001 |
132989 | C4orf36 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.87e-06 | 2.60e-01 | -0.059 |
132989 | C4orf36 | HTA11_2992_2000001011 | Human | Colorectum | SER | 7.66e-03 | 2.96e-01 | -0.1706 |
132989 | C4orf36 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.39e-04 | 4.01e-01 | -0.1462 |
132989 | C4orf36 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.91e-08 | 3.88e-01 | -0.0842 |
132989 | C4orf36 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.69e-02 | 4.24e-01 | -0.00410000000000005 |
132989 | C4orf36 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.05e-03 | 1.69e-01 | 0.096 |
132989 | C4orf36 | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.70e-03 | 3.22e-01 | 0.0446 |
132989 | C4orf36 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.96e-05 | 3.56e-01 | -0.0177 |
132989 | C4orf36 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.33e-08 | 3.23e-01 | 0.0338 |
132989 | C4orf36 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.18e-03 | 1.99e-01 | 0.0674 |
132989 | C4orf36 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.23e-02 | 3.63e-01 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C4orf36 | SNV | Missense_Mutation | c.161G>A | p.Gly54Asp | p.G54D | Q96KX1 | protein_coding | tolerated(0.46) | benign(0.058) | TCGA-AO-A124-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
C4orf36 | SNV | Missense_Mutation | c.172N>G | p.Leu58Val | p.L58V | Q96KX1 | protein_coding | deleterious(0.01) | possibly_damaging(0.802) | TCGA-BH-A0HN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
C4orf36 | SNV | Missense_Mutation | novel | c.85G>A | p.Ala29Thr | p.A29T | Q96KX1 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C4orf36 | SNV | Missense_Mutation | rs771464463 | c.253N>T | p.Arg85Cys | p.R85C | Q96KX1 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C4orf36 | SNV | Missense_Mutation | novel | c.335N>T | p.Arg112Ile | p.R112I | Q96KX1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C4orf36 | SNV | Missense_Mutation | novel | c.99N>T | p.Lys33Asn | p.K33N | Q96KX1 | protein_coding | deleterious(0) | possibly_damaging(0.646) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C4orf36 | SNV | Missense_Mutation | c.195N>C | p.Lys65Asn | p.K65N | Q96KX1 | protein_coding | deleterious(0.01) | possibly_damaging(0.571) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C4orf36 | SNV | Missense_Mutation | c.184A>G | p.Thr62Ala | p.T62A | Q96KX1 | protein_coding | tolerated(0.25) | benign(0.001) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
C4orf36 | SNV | Missense_Mutation | rs779308489 | c.126N>G | p.Ile42Met | p.I42M | Q96KX1 | protein_coding | deleterious(0.05) | possibly_damaging(0.509) | TCGA-BA-6868-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
C4orf36 | SNV | Missense_Mutation | c.295N>G | p.Ile99Val | p.I99V | Q96KX1 | protein_coding | tolerated(0.42) | benign(0.011) | TCGA-BR-7958-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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