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Gene: C14orf132 |
Gene summary for C14ORF132 |
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Gene information | Species | Human | Gene symbol | C14orf132 | Gene ID | 56967 |
Gene name | chromosome 14 open reading frame 132 | |
Gene Alias | C14orf88 | |
Cytomap | 14q32.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NPU4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56967 | C14orf132 | P2T-E | Human | Esophagus | ESCC | 1.48e-06 | 1.35e-01 | 0.1177 |
56967 | C14orf132 | P4T-E | Human | Esophagus | ESCC | 4.52e-11 | 1.62e-01 | 0.1323 |
56967 | C14orf132 | P5T-E | Human | Esophagus | ESCC | 7.75e-03 | 1.45e-02 | 0.1327 |
56967 | C14orf132 | P10T-E | Human | Esophagus | ESCC | 5.91e-16 | 2.14e-01 | 0.116 |
56967 | C14orf132 | P16T-E | Human | Esophagus | ESCC | 5.73e-08 | 2.02e-01 | 0.1153 |
56967 | C14orf132 | P20T-E | Human | Esophagus | ESCC | 2.42e-03 | 1.19e-01 | 0.1124 |
56967 | C14orf132 | P21T-E | Human | Esophagus | ESCC | 2.99e-05 | 1.16e-01 | 0.1617 |
56967 | C14orf132 | P22T-E | Human | Esophagus | ESCC | 2.08e-03 | 2.64e-02 | 0.1236 |
56967 | C14orf132 | P24T-E | Human | Esophagus | ESCC | 2.10e-04 | 5.74e-02 | 0.1287 |
56967 | C14orf132 | P26T-E | Human | Esophagus | ESCC | 2.68e-03 | 7.04e-02 | 0.1276 |
56967 | C14orf132 | P27T-E | Human | Esophagus | ESCC | 6.73e-14 | 2.35e-01 | 0.1055 |
56967 | C14orf132 | P28T-E | Human | Esophagus | ESCC | 1.03e-02 | 4.79e-02 | 0.1149 |
56967 | C14orf132 | P30T-E | Human | Esophagus | ESCC | 1.52e-07 | 3.40e-01 | 0.137 |
56967 | C14orf132 | P31T-E | Human | Esophagus | ESCC | 1.12e-07 | 1.29e-01 | 0.1251 |
56967 | C14orf132 | P32T-E | Human | Esophagus | ESCC | 2.73e-10 | 2.01e-01 | 0.1666 |
56967 | C14orf132 | P37T-E | Human | Esophagus | ESCC | 7.62e-11 | 3.06e-01 | 0.1371 |
56967 | C14orf132 | P49T-E | Human | Esophagus | ESCC | 1.08e-05 | 7.85e-01 | 0.1768 |
56967 | C14orf132 | P52T-E | Human | Esophagus | ESCC | 1.05e-06 | 1.17e-01 | 0.1555 |
56967 | C14orf132 | P54T-E | Human | Esophagus | ESCC | 1.20e-12 | 3.08e-01 | 0.0975 |
56967 | C14orf132 | P57T-E | Human | Esophagus | ESCC | 9.57e-07 | 1.54e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C14orf132 | SNV | Missense_Mutation | rs768929085 | c.265N>A | p.Ala89Thr | p.A89T | protein_coding | tolerated_low_confidence(0.09) | probably_damaging(0.998) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
C14orf132 | SNV | Missense_Mutation | rs559444081 | c.250N>T | p.Arg84Trp | p.R84W | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
C14orf132 | SNV | Missense_Mutation | novel | c.5A>C | p.Asp2Ala | p.D2A | protein_coding | deleterious_low_confidence(0) | benign(0.277) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C14orf132 | SNV | Missense_Mutation | rs749600595 | c.262N>A | p.Asp88Asn | p.D88N | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
C14orf132 | SNV | Missense_Mutation | novel | c.181N>C | p.Ser61Pro | p.S61P | protein_coding | deleterious_low_confidence(0.04) | benign(0.084) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
C14orf132 | deletion | Frame_Shift_Del | novel | c.132delN | p.Gly46GlufsTer52 | p.G46Efs*52 | protein_coding | TCGA-AX-A3G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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