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Gene: BCAS1 |
Gene summary for BCAS1 |
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Gene information | Species | Human | Gene symbol | BCAS1 | Gene ID | 8537 |
Gene name | brain enriched myelin associated protein 1 | |
Gene Alias | AIBC1 | |
Cytomap | 20q13.2 | |
Gene Type | protein-coding | GO ID | GO:0007272 | UniProtAcc | B2RCQ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8537 | BCAS1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.30e-15 | 8.78e-01 | -0.1808 |
8537 | BCAS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.86e-06 | 6.81e-01 | -0.0811 |
8537 | BCAS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.06e-27 | 1.29e+00 | -0.1088 |
8537 | BCAS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.40e-32 | 1.14e+00 | -0.1954 |
8537 | BCAS1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.02e-12 | 1.97e+00 | -0.2602 |
8537 | BCAS1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.17e-09 | 2.24e+00 | -0.2196 |
8537 | BCAS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.13e-08 | 7.53e-01 | -0.1207 |
8537 | BCAS1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.43e-07 | 9.19e-01 | -0.1526 |
8537 | BCAS1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.82e-21 | 9.79e-01 | -0.1464 |
8537 | BCAS1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.86e-15 | 7.23e-01 | -0.1001 |
8537 | BCAS1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.07e-02 | 8.85e-01 | -0.1706 |
8537 | BCAS1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.27e-13 | 1.16e+00 | -0.2061 |
8537 | BCAS1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.14e-03 | 6.04e-01 | -0.0842 |
8537 | BCAS1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.10e-06 | -3.32e-01 | 0.294 |
8537 | BCAS1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.94e-08 | -3.98e-01 | 0.3859 |
8537 | BCAS1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.28e-02 | -4.50e-01 | 0.2585 |
8537 | BCAS1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.72e-03 | -2.80e-01 | 0.3005 |
8537 | BCAS1 | A015-C-203 | Human | Colorectum | FAP | 1.65e-10 | -1.90e-01 | -0.1294 |
8537 | BCAS1 | A002-C-201 | Human | Colorectum | FAP | 4.99e-04 | -1.04e-01 | 0.0324 |
8537 | BCAS1 | A001-C-119 | Human | Colorectum | FAP | 2.39e-03 | -3.45e-01 | -0.1557 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00425522 | Prostate | Tumor | myelination | 34/3246 | 134/18723 | 1.19e-02 | 4.85e-02 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCAS1 | SNV | Missense_Mutation | c.49N>A | p.Glu17Lys | p.E17K | O75363 | protein_coding | tolerated(0.27) | benign(0.297) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
BCAS1 | SNV | Missense_Mutation | novel | c.1195N>C | p.Ser399Pro | p.S399P | O75363 | protein_coding | tolerated(0.11) | benign(0.027) | TCGA-A7-A0D9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
BCAS1 | SNV | Missense_Mutation | c.592N>A | p.Phe198Ile | p.F198I | O75363 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A08G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
BCAS1 | SNV | Missense_Mutation | c.562C>T | p.Pro188Ser | p.P188S | O75363 | protein_coding | tolerated(0.12) | benign(0.11) | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
BCAS1 | SNV | Missense_Mutation | c.663N>C | p.Gln221His | p.Q221H | O75363 | protein_coding | tolerated(0.24) | benign(0.009) | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BCAS1 | SNV | Missense_Mutation | novel | c.155T>G | p.Ile52Arg | p.I52R | O75363 | protein_coding | deleterious(0.04) | possibly_damaging(0.885) | TCGA-C8-A1HG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BCAS1 | SNV | Missense_Mutation | c.1348N>T | p.Met450Leu | p.M450L | O75363 | protein_coding | tolerated(0.54) | benign(0.131) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BCAS1 | SNV | Missense_Mutation | c.1384N>A | p.Glu462Lys | p.E462K | O75363 | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BCAS1 | SNV | Missense_Mutation | rs145068978 | c.1448C>T | p.Pro483Leu | p.P483L | O75363 | protein_coding | deleterious(0.02) | benign(0.213) | TCGA-E9-A248-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
BCAS1 | SNV | Missense_Mutation | rs750081990 | c.259N>A | p.Glu87Lys | p.E87K | O75363 | protein_coding | tolerated(0.57) | benign(0.011) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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