![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ARMCX5 |
Gene summary for ARMCX5 |
![]() |
Gene information | Species | Human | Gene symbol | ARMCX5 | Gene ID | 64860 |
Gene name | armadillo repeat containing X-linked 5 | |
Gene Alias | GASP5 | |
Cytomap | Xq22.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6P1M9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64860 | ARMCX5 | LZE4T | Human | Esophagus | ESCC | 1.31e-02 | 9.67e-02 | 0.0811 |
64860 | ARMCX5 | LZE24T | Human | Esophagus | ESCC | 1.07e-04 | 1.11e-01 | 0.0596 |
64860 | ARMCX5 | P1T-E | Human | Esophagus | ESCC | 6.30e-05 | 2.35e-01 | 0.0875 |
64860 | ARMCX5 | P2T-E | Human | Esophagus | ESCC | 1.01e-22 | 4.27e-01 | 0.1177 |
64860 | ARMCX5 | P4T-E | Human | Esophagus | ESCC | 2.68e-22 | 3.51e-01 | 0.1323 |
64860 | ARMCX5 | P5T-E | Human | Esophagus | ESCC | 3.39e-13 | 8.29e-02 | 0.1327 |
64860 | ARMCX5 | P8T-E | Human | Esophagus | ESCC | 8.19e-16 | 2.23e-01 | 0.0889 |
64860 | ARMCX5 | P9T-E | Human | Esophagus | ESCC | 8.00e-11 | 1.91e-01 | 0.1131 |
64860 | ARMCX5 | P10T-E | Human | Esophagus | ESCC | 3.30e-24 | 3.43e-01 | 0.116 |
64860 | ARMCX5 | P11T-E | Human | Esophagus | ESCC | 2.41e-08 | 2.56e-01 | 0.1426 |
64860 | ARMCX5 | P12T-E | Human | Esophagus | ESCC | 3.26e-19 | 3.17e-01 | 0.1122 |
64860 | ARMCX5 | P15T-E | Human | Esophagus | ESCC | 1.05e-14 | 2.55e-01 | 0.1149 |
64860 | ARMCX5 | P16T-E | Human | Esophagus | ESCC | 3.39e-19 | 1.63e-01 | 0.1153 |
64860 | ARMCX5 | P17T-E | Human | Esophagus | ESCC | 1.05e-07 | 3.34e-01 | 0.1278 |
64860 | ARMCX5 | P20T-E | Human | Esophagus | ESCC | 1.81e-17 | 3.56e-01 | 0.1124 |
64860 | ARMCX5 | P21T-E | Human | Esophagus | ESCC | 1.73e-16 | 1.39e-01 | 0.1617 |
64860 | ARMCX5 | P22T-E | Human | Esophagus | ESCC | 1.12e-11 | 2.02e-01 | 0.1236 |
64860 | ARMCX5 | P23T-E | Human | Esophagus | ESCC | 3.82e-15 | 4.32e-01 | 0.108 |
64860 | ARMCX5 | P24T-E | Human | Esophagus | ESCC | 8.10e-09 | 1.90e-01 | 0.1287 |
64860 | ARMCX5 | P26T-E | Human | Esophagus | ESCC | 2.00e-27 | 4.44e-01 | 0.1276 |
Page: 1 2 3 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARMCX5 | SNV | Missense_Mutation | rs753200471 | c.1389N>A | p.His463Gln | p.H463Q | Q6P1M9 | protein_coding | tolerated(1) | benign(0) | TCGA-A8-A08J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ARMCX5 | SNV | Missense_Mutation | novel | c.1370C>T | p.Ser457Leu | p.S457L | Q6P1M9 | protein_coding | tolerated(1) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARMCX5 | SNV | Missense_Mutation | c.1334G>T | p.Ser445Ile | p.S445I | Q6P1M9 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-AN-A0FY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ARMCX5 | SNV | Missense_Mutation | c.437N>G | p.Thr146Ser | p.T146S | Q6P1M9 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARMCX5 | SNV | Missense_Mutation | c.937G>C | p.Asp313His | p.D313H | Q6P1M9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-BH-A18H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
ARMCX5 | SNV | Missense_Mutation | novel | c.1453A>G | p.Asn485Asp | p.N485D | Q6P1M9 | protein_coding | tolerated(0.05) | benign(0.242) | TCGA-LL-A73Z-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
ARMCX5 | insertion | Frame_Shift_Ins | novel | c.1472_1473insA | p.Leu492SerfsTer2 | p.L492Sfs*2 | Q6P1M9 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ARMCX5 | SNV | Missense_Mutation | novel | c.395N>T | p.Ala132Val | p.A132V | Q6P1M9 | protein_coding | tolerated(0.46) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARMCX5 | SNV | Missense_Mutation | c.458N>A | p.Arg153Lys | p.R153K | Q6P1M9 | protein_coding | tolerated(0.82) | benign(0) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ARMCX5 | SNV | Missense_Mutation | novel | c.679N>A | p.Ala227Thr | p.A227T | Q6P1M9 | protein_coding | deleterious(0.02) | benign(0.19) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |