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Gene: APOPT1 |
Gene summary for APOPT1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | APOPT1 | Gene ID | 84334 |
Gene name | cytochrome c oxidase assembly factor 8 | |
Gene Alias | APOP | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | Q96IL0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84334 | APOPT1 | P1T-E | Human | Esophagus | ESCC | 6.23e-06 | 1.34e-01 | 0.0875 |
84334 | APOPT1 | P2T-E | Human | Esophagus | ESCC | 3.85e-10 | -1.03e-02 | 0.1177 |
84334 | APOPT1 | P4T-E | Human | Esophagus | ESCC | 2.94e-08 | 7.86e-02 | 0.1323 |
84334 | APOPT1 | P5T-E | Human | Esophagus | ESCC | 1.50e-09 | 1.47e-01 | 0.1327 |
84334 | APOPT1 | P8T-E | Human | Esophagus | ESCC | 1.31e-10 | 2.44e-01 | 0.0889 |
84334 | APOPT1 | P9T-E | Human | Esophagus | ESCC | 1.89e-05 | 4.51e-02 | 0.1131 |
84334 | APOPT1 | P10T-E | Human | Esophagus | ESCC | 2.07e-53 | 1.06e+00 | 0.116 |
84334 | APOPT1 | P12T-E | Human | Esophagus | ESCC | 8.47e-16 | 2.72e-01 | 0.1122 |
84334 | APOPT1 | P15T-E | Human | Esophagus | ESCC | 2.26e-14 | 3.42e-01 | 0.1149 |
84334 | APOPT1 | P16T-E | Human | Esophagus | ESCC | 7.42e-05 | 5.57e-02 | 0.1153 |
84334 | APOPT1 | P17T-E | Human | Esophagus | ESCC | 3.79e-10 | 2.15e-01 | 0.1278 |
84334 | APOPT1 | P19T-E | Human | Esophagus | ESCC | 1.19e-04 | 4.02e-01 | 0.1662 |
84334 | APOPT1 | P20T-E | Human | Esophagus | ESCC | 1.87e-10 | 2.36e-01 | 0.1124 |
84334 | APOPT1 | P21T-E | Human | Esophagus | ESCC | 1.57e-17 | 1.33e-01 | 0.1617 |
84334 | APOPT1 | P22T-E | Human | Esophagus | ESCC | 1.85e-08 | 1.55e-01 | 0.1236 |
84334 | APOPT1 | P23T-E | Human | Esophagus | ESCC | 4.50e-18 | 2.69e-01 | 0.108 |
84334 | APOPT1 | P24T-E | Human | Esophagus | ESCC | 8.70e-16 | 1.83e-01 | 0.1287 |
84334 | APOPT1 | P26T-E | Human | Esophagus | ESCC | 3.21e-10 | 1.70e-01 | 0.1276 |
84334 | APOPT1 | P27T-E | Human | Esophagus | ESCC | 2.12e-14 | 1.49e-01 | 0.1055 |
84334 | APOPT1 | P28T-E | Human | Esophagus | ESCC | 2.27e-15 | 3.64e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | |
Breast | IDC | |
Breast | DCIS | |
Cervix | CC | |
Cervix | HSIL_HPV |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
APOPT1 | SNV | Missense_Mutation | rs756550363 | c.530N>A | p.Arg177His | p.R177H | Q96IL0 | protein_coding | deleterious(0.03) | possibly_damaging(0.765) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
APOPT1 | SNV | Missense_Mutation | c.527N>C | p.Lys176Thr | p.K176T | Q96IL0 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APOPT1 | SNV | Missense_Mutation | c.539N>T | p.Ala180Val | p.A180V | Q96IL0 | protein_coding | tolerated(0.06) | benign(0.025) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
APOPT1 | SNV | Missense_Mutation | novel | c.217G>T | p.Asp73Tyr | p.D73Y | Q96IL0 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
APOPT1 | SNV | Missense_Mutation | novel | c.292A>C | p.Lys98Gln | p.K98Q | Q96IL0 | protein_coding | tolerated(0.14) | benign(0.022) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APOPT1 | SNV | Missense_Mutation | rs756869402 | c.255N>G | p.Ile85Met | p.I85M | Q96IL0 | protein_coding | deleterious(0.01) | possibly_damaging(0.77) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
APOPT1 | SNV | Missense_Mutation | rs562472810 | c.472N>A | p.Glu158Lys | p.E158K | Q96IL0 | protein_coding | tolerated(0.11) | benign(0.339) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
APOPT1 | SNV | Missense_Mutation | c.415N>G | p.Thr139Ala | p.T139A | Q96IL0 | protein_coding | tolerated(0.62) | benign(0.001) | TCGA-BC-4073-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | sorafenib | SD | |
APOPT1 | SNV | Missense_Mutation | novel | c.40N>T | p.Met14Leu | p.M14L | Q96IL0 | protein_coding | tolerated(0.15) | benign(0) | TCGA-DD-AACL-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
APOPT1 | SNV | Missense_Mutation | rs747124583 | c.370N>A | p.Glu124Lys | p.E124K | Q96IL0 | protein_coding | tolerated(0.11) | benign(0.031) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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