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Gene: ADPRHL2 |
Gene summary for ADPRHL2 |
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Gene information | Species | Human | Gene symbol | ADPRHL2 | Gene ID | 54936 |
Gene name | ADP-ribosylserine hydrolase | |
Gene Alias | ADPRHL2 | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | Q9NX46 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54936 | ADPRHL2 | LZE4T | Human | Esophagus | ESCC | 2.57e-04 | 1.03e-01 | 0.0811 |
54936 | ADPRHL2 | LZE7T | Human | Esophagus | ESCC | 3.99e-10 | 2.94e-01 | 0.0667 |
54936 | ADPRHL2 | LZE20T | Human | Esophagus | ESCC | 5.50e-03 | 1.71e-01 | 0.0662 |
54936 | ADPRHL2 | LZE22T | Human | Esophagus | ESCC | 2.49e-02 | 1.33e-01 | 0.068 |
54936 | ADPRHL2 | LZE24T | Human | Esophagus | ESCC | 2.28e-17 | 4.23e-01 | 0.0596 |
54936 | ADPRHL2 | P1T-E | Human | Esophagus | ESCC | 3.84e-08 | 1.88e-01 | 0.0875 |
54936 | ADPRHL2 | P2T-E | Human | Esophagus | ESCC | 4.58e-25 | 4.72e-01 | 0.1177 |
54936 | ADPRHL2 | P4T-E | Human | Esophagus | ESCC | 3.24e-20 | 4.29e-01 | 0.1323 |
54936 | ADPRHL2 | P5T-E | Human | Esophagus | ESCC | 1.61e-23 | 4.68e-01 | 0.1327 |
54936 | ADPRHL2 | P8T-E | Human | Esophagus | ESCC | 1.14e-21 | 2.89e-01 | 0.0889 |
54936 | ADPRHL2 | P9T-E | Human | Esophagus | ESCC | 5.14e-09 | 2.66e-01 | 0.1131 |
54936 | ADPRHL2 | P10T-E | Human | Esophagus | ESCC | 2.69e-29 | 5.11e-01 | 0.116 |
54936 | ADPRHL2 | P11T-E | Human | Esophagus | ESCC | 1.05e-09 | 6.37e-01 | 0.1426 |
54936 | ADPRHL2 | P12T-E | Human | Esophagus | ESCC | 8.43e-26 | 4.32e-01 | 0.1122 |
54936 | ADPRHL2 | P15T-E | Human | Esophagus | ESCC | 6.15e-25 | 4.32e-01 | 0.1149 |
54936 | ADPRHL2 | P16T-E | Human | Esophagus | ESCC | 3.78e-23 | 3.06e-01 | 0.1153 |
54936 | ADPRHL2 | P17T-E | Human | Esophagus | ESCC | 3.86e-12 | 4.32e-01 | 0.1278 |
54936 | ADPRHL2 | P19T-E | Human | Esophagus | ESCC | 1.87e-02 | 4.29e-01 | 0.1662 |
54936 | ADPRHL2 | P20T-E | Human | Esophagus | ESCC | 3.32e-18 | 4.43e-01 | 0.1124 |
54936 | ADPRHL2 | P21T-E | Human | Esophagus | ESCC | 3.22e-34 | 7.31e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Breast | Precancer | ![]() |
Breast | IDC | ![]() |
Breast | DCIS | ![]() |
Cervix | CC | ![]() |
Cervix | HSIL_HPV | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADPRHL2 | SNV | Missense_Mutation | c.331N>A | p.Asp111Asn | p.D111N | Q9NX46 | protein_coding | deleterious(0.02) | benign(0.043) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ADPRHL2 | SNV | Missense_Mutation | rs148612837 | c.719G>A | p.Arg240His | p.R240H | Q9NX46 | protein_coding | tolerated(0.56) | benign(0.001) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ADPRHL2 | SNV | Missense_Mutation | c.179C>A | p.Pro60Gln | p.P60Q | Q9NX46 | protein_coding | tolerated(0.24) | possibly_damaging(0.606) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ADPRHL2 | SNV | Missense_Mutation | novel | c.690G>T | p.Leu230Phe | p.L230F | Q9NX46 | protein_coding | tolerated(0.12) | benign(0) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ADPRHL2 | SNV | Missense_Mutation | c.251C>T | p.Ala84Val | p.A84V | Q9NX46 | protein_coding | tolerated(0.13) | benign(0.073) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ADPRHL2 | SNV | Missense_Mutation | rs201025691 | c.718C>T | p.Arg240Cys | p.R240C | Q9NX46 | protein_coding | tolerated(0.18) | benign(0.009) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ADPRHL2 | SNV | Missense_Mutation | novel | c.400G>A | p.Asp134Asn | p.D134N | Q9NX46 | protein_coding | deleterious(0.01) | possibly_damaging(0.787) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADPRHL2 | SNV | Missense_Mutation | rs769583828 | c.418C>T | p.Arg140Trp | p.R140W | Q9NX46 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ADPRHL2 | SNV | Missense_Mutation | rs756440961 | c.856C>T | p.Arg286Cys | p.R286C | Q9NX46 | protein_coding | deleterious(0) | possibly_damaging(0.784) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADPRHL2 | SNV | Missense_Mutation | novel | c.247N>G | p.Arg83Gly | p.R83G | Q9NX46 | protein_coding | deleterious(0) | possibly_damaging(0.594) | TCGA-AJ-A8CV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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