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Gene: ZNF652 |
Gene summary for ZNF652 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF652 | Gene ID | 22834 |
Gene name | zinc finger protein 652 | |
Gene Alias | ZNF652 | |
Cytomap | 17q21.32-q21.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A8K9F2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22834 | ZNF652 | GSM4909298 | Human | Breast | IDC | 7.91e-24 | 5.38e-01 | 0.1551 |
22834 | ZNF652 | GSM4909302 | Human | Breast | IDC | 1.32e-15 | 5.64e-01 | 0.1545 |
22834 | ZNF652 | GSM4909303 | Human | Breast | IDC | 6.83e-07 | 5.22e-01 | 0.0438 |
22834 | ZNF652 | GSM4909304 | Human | Breast | IDC | 2.94e-09 | 3.29e-01 | 0.1636 |
22834 | ZNF652 | GSM4909311 | Human | Breast | IDC | 6.97e-05 | -1.46e-01 | 0.1534 |
22834 | ZNF652 | GSM4909319 | Human | Breast | IDC | 7.38e-08 | -1.38e-01 | 0.1563 |
22834 | ZNF652 | M1 | Human | Breast | IDC | 9.00e-06 | 3.32e-01 | 0.1577 |
22834 | ZNF652 | M5 | Human | Breast | IDC | 5.35e-06 | 7.26e-01 | 0.1598 |
22834 | ZNF652 | NCCBC14 | Human | Breast | DCIS | 1.46e-03 | 3.15e-01 | 0.2021 |
22834 | ZNF652 | P1 | Human | Breast | IDC | 5.25e-03 | 1.36e-01 | 0.1527 |
22834 | ZNF652 | DCIS2 | Human | Breast | DCIS | 2.84e-60 | 4.86e-01 | 0.0085 |
22834 | ZNF652 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.96e-03 | -1.41e-01 | 0.0155 |
22834 | ZNF652 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.91e-11 | 6.20e-01 | -0.1954 |
22834 | ZNF652 | F007 | Human | Colorectum | FAP | 5.02e-03 | -2.74e-01 | 0.1176 |
22834 | ZNF652 | A001-C-207 | Human | Colorectum | FAP | 1.35e-02 | -1.93e-01 | 0.1278 |
22834 | ZNF652 | A015-C-203 | Human | Colorectum | FAP | 1.52e-22 | -3.42e-01 | -0.1294 |
22834 | ZNF652 | A015-C-204 | Human | Colorectum | FAP | 2.57e-04 | -2.32e-01 | -0.0228 |
22834 | ZNF652 | A014-C-040 | Human | Colorectum | FAP | 4.33e-04 | -4.70e-01 | -0.1184 |
22834 | ZNF652 | A002-C-201 | Human | Colorectum | FAP | 1.41e-09 | -2.90e-01 | 0.0324 |
22834 | ZNF652 | A002-C-203 | Human | Colorectum | FAP | 3.90e-02 | -1.47e-01 | 0.2786 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | |
Lung | IAC | |
Lung | AIS | |
Lung | AAH | |
Lung | MIAC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF652 | SNV | Missense_Mutation | c.328N>A | p.Val110Ile | p.V110I | Q9Y2D9 | protein_coding | tolerated(0.23) | benign(0.046) | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
ZNF652 | SNV | Missense_Mutation | novel | c.220N>A | p.Glu74Lys | p.E74K | Q9Y2D9 | protein_coding | tolerated(0.62) | benign(0.026) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF652 | SNV | Missense_Mutation | rs537777094 | c.1621C>T | p.Arg541Trp | p.R541W | Q9Y2D9 | protein_coding | deleterious(0.01) | possibly_damaging(0.446) | TCGA-AC-A3YI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
ZNF652 | SNV | Missense_Mutation | novel | c.1799N>C | p.Asn600Thr | p.N600T | Q9Y2D9 | protein_coding | tolerated_low_confidence(0.19) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF652 | SNV | Missense_Mutation | c.286N>C | p.Asp96His | p.D96H | Q9Y2D9 | protein_coding | tolerated(0.08) | benign(0.275) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
ZNF652 | SNV | Missense_Mutation | c.1556T>C | p.Val519Ala | p.V519A | Q9Y2D9 | protein_coding | tolerated_low_confidence(0.82) | benign(0) | TCGA-E2-A15M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ZNF652 | SNV | Missense_Mutation | novel | c.694N>A | p.Ala232Thr | p.A232T | Q9Y2D9 | protein_coding | deleterious(0.01) | benign(0.054) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF652 | SNV | Missense_Mutation | c.1261G>T | p.Asp421Tyr | p.D421Y | Q9Y2D9 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF652 | SNV | Missense_Mutation | c.809G>A | p.Arg270His | p.R270H | Q9Y2D9 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF652 | SNV | Missense_Mutation | rs770946812 | c.460G>A | p.Glu154Lys | p.E154K | Q9Y2D9 | protein_coding | tolerated(0.18) | benign(0.051) | TCGA-AA-3968-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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