Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ZNF581_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ZNF581_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ZNF581_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ZNF581_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ZNF581_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ZNF581_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF581 | MAST | Cervix | ADJ | TPSAB1,TCEAL3,SIGLEC6, etc. | 4.32e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF581 | MAST | Cervix | CC | TPSAB1,TCEAL3,SIGLEC6, etc. | 8.90e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF581 | BN | Cervix | Healthy | TPSAB1,TCEAL3,SIGLEC6, etc. | 8.13e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF581 | MAST | Cervix | HSIL_HPV | TPSAB1,TCEAL3,SIGLEC6, etc. | 2.57e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_HSIL_HPV/regulons_activity_in_dotplot.png) |
ZNF581 | BN | Cervix | N_HPV | TPSAB1,TCEAL3,SIGLEC6, etc. | 1.23e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_N_HPV/regulons_activity_in_dotplot.png) |
ZNF581 | M2MAC | Esophagus | ADJ | BOD1,DVL1,MRPL48, etc. | 2.37e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF581 | M2MAC | Esophagus | ESCC | BOD1,DVL1,MRPL48, etc. | 2.39e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ESCC/regulons_activity_in_dotplot.png) |
ZNF581 | SEC | Liver | Cirrhotic | METTL18,GEMIN4,FCN2, etc. | 1.11e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_Cirrhotic/regulons_activity_in_dotplot.png) |
ZNF581 | SEC | Liver | HCC | METTL18,GEMIN4,FCN2, etc. | 1.43e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_HCC/regulons_activity_in_dotplot.png) |
ZNF581 | PVA | Liver | HCC | METTL18,GEMIN4,FCN2, etc. | 1.88e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_HCC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF581 | insertion | In_Frame_Ins | novel | c.221_222insGCCAGGGGCCAGTGTGGCTCCAGGCCAGAAAAAGTGCAACAGCTG | p.Ser78_Gly79insValAlaProGlyGlnLysLysCysAsnSerTrpProGlyAlaSer | p.S78_G79insVAPGQKKCNSWPGAS | Q9P0T4 | protein_coding | | | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
ZNF581 | SNV | Missense_Mutation | novel | c.47C>T | p.Ser16Phe | p.S16F | Q9P0T4 | protein_coding | tolerated(0.08) | possibly_damaging(0.837) | TCGA-C5-A2LV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF581 | SNV | Missense_Mutation | | c.329N>G | p.Ser110Trp | p.S110W | Q9P0T4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF581 | SNV | Missense_Mutation | novel | c.142N>T | p.Pro48Ser | p.P48S | Q9P0T4 | protein_coding | tolerated(0.53) | benign(0) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ZNF581 | SNV | Missense_Mutation | | c.289G>A | p.Glu97Lys | p.E97K | Q9P0T4 | protein_coding | tolerated(0.35) | benign(0.148) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF581 | SNV | Missense_Mutation | novel | c.63G>T | p.Glu21Asp | p.E21D | Q9P0T4 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ZNF581 | deletion | Frame_Shift_Del | | c.17delN | p.Cys8AlafsTer105 | p.C8Afs*105 | Q9P0T4 | protein_coding | | | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZNF581 | SNV | Missense_Mutation | novel | c.63G>T | p.Glu21Asp | p.E21D | Q9P0T4 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF581 | SNV | Missense_Mutation | novel | c.238G>A | p.Ala80Thr | p.A80T | Q9P0T4 | protein_coding | tolerated(0.53) | benign(0.006) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF581 | SNV | Missense_Mutation | novel | c.339N>T | p.Lys113Asn | p.K113N | Q9P0T4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |