![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF546 |
Gene summary for ZNF546 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF546 | Gene ID | 339327 |
Gene name | zinc finger protein 546 | |
Gene Alias | ZNF49 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KVL3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339327 | ZNF546 | PTC07 | Human | Thyroid | PTC | 5.55e-04 | 7.52e-02 | 0.2044 |
339327 | ZNF546 | ATC13 | Human | Thyroid | ATC | 1.65e-35 | 6.03e-01 | 0.34 |
339327 | ZNF546 | ATC5 | Human | Thyroid | ATC | 7.13e-34 | 6.47e-01 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF546 | SNV | Missense_Mutation | c.1072N>A | p.Glu358Lys | p.E358K | Q86UE3 | protein_coding | tolerated(0.21) | benign(0.048) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
ZNF546 | SNV | Missense_Mutation | novel | c.175N>C | p.Ser59Pro | p.S59P | Q86UE3 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZNF546 | SNV | Missense_Mutation | c.2212N>G | p.Gln738Glu | p.Q738E | Q86UE3 | protein_coding | tolerated(1) | benign(0.03) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF546 | SNV | Missense_Mutation | novel | c.2051N>G | p.His684Arg | p.H684R | Q86UE3 | protein_coding | tolerated(0.09) | benign(0.051) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF546 | SNV | Missense_Mutation | c.68A>G | p.His23Arg | p.H23R | Q86UE3 | protein_coding | tolerated_low_confidence(0.39) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZNF546 | SNV | Missense_Mutation | c.1990N>G | p.Pro664Ala | p.P664A | Q86UE3 | protein_coding | deleterious(0.01) | possibly_damaging(0.905) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ZNF546 | SNV | Missense_Mutation | c.1882N>T | p.His628Tyr | p.H628Y | Q86UE3 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF546 | SNV | Missense_Mutation | c.642N>T | p.Glu214Asp | p.E214D | Q86UE3 | protein_coding | deleterious(0.03) | benign(0.044) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZNF546 | SNV | Missense_Mutation | novel | c.357N>C | p.Trp119Cys | p.W119C | Q86UE3 | protein_coding | deleterious(0.03) | probably_damaging(0.993) | TCGA-EW-A6S9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF546 | SNV | Missense_Mutation | novel | c.2409A>C | p.Lys803Asn | p.K803N | Q86UE3 | protein_coding | deleterious(0.03) | possibly_damaging(0.57) | TCGA-LL-A7SZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |