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Gene: ZNF444 |
Gene summary for ZNF444 |
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Gene information | Species | Human | Gene symbol | ZNF444 | Gene ID | 55311 |
Gene name | zinc finger protein 444 | |
Gene Alias | EZF-2 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R4P4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55311 | ZNF444 | LZE22D1 | Human | Esophagus | HGIN | 9.28e-03 | 1.52e-01 | 0.0595 |
55311 | ZNF444 | LZE24T | Human | Esophagus | ESCC | 1.90e-15 | 3.12e-01 | 0.0596 |
55311 | ZNF444 | P1T-E | Human | Esophagus | ESCC | 6.18e-03 | 1.15e-01 | 0.0875 |
55311 | ZNF444 | P2T-E | Human | Esophagus | ESCC | 1.85e-07 | 1.52e-01 | 0.1177 |
55311 | ZNF444 | P4T-E | Human | Esophagus | ESCC | 1.01e-08 | 1.86e-01 | 0.1323 |
55311 | ZNF444 | P8T-E | Human | Esophagus | ESCC | 2.73e-30 | 4.38e-01 | 0.0889 |
55311 | ZNF444 | P9T-E | Human | Esophagus | ESCC | 6.12e-05 | 1.19e-01 | 0.1131 |
55311 | ZNF444 | P10T-E | Human | Esophagus | ESCC | 2.47e-26 | 3.41e-01 | 0.116 |
55311 | ZNF444 | P11T-E | Human | Esophagus | ESCC | 5.70e-14 | 3.19e-01 | 0.1426 |
55311 | ZNF444 | P12T-E | Human | Esophagus | ESCC | 1.78e-13 | 2.67e-01 | 0.1122 |
55311 | ZNF444 | P15T-E | Human | Esophagus | ESCC | 5.38e-17 | 2.90e-01 | 0.1149 |
55311 | ZNF444 | P16T-E | Human | Esophagus | ESCC | 2.31e-13 | 1.79e-01 | 0.1153 |
55311 | ZNF444 | P17T-E | Human | Esophagus | ESCC | 8.18e-08 | 2.54e-01 | 0.1278 |
55311 | ZNF444 | P19T-E | Human | Esophagus | ESCC | 8.25e-07 | 4.04e-01 | 0.1662 |
55311 | ZNF444 | P20T-E | Human | Esophagus | ESCC | 5.41e-11 | 9.71e-02 | 0.1124 |
55311 | ZNF444 | P21T-E | Human | Esophagus | ESCC | 1.61e-12 | 1.23e-01 | 0.1617 |
55311 | ZNF444 | P22T-E | Human | Esophagus | ESCC | 6.84e-13 | 2.23e-01 | 0.1236 |
55311 | ZNF444 | P23T-E | Human | Esophagus | ESCC | 9.70e-12 | 2.33e-01 | 0.108 |
55311 | ZNF444 | P24T-E | Human | Esophagus | ESCC | 4.37e-15 | 1.65e-01 | 0.1287 |
55311 | ZNF444 | P26T-E | Human | Esophagus | ESCC | 9.42e-27 | 4.43e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF444 | SNV | Missense_Mutation | c.154N>A | p.Glu52Lys | p.E52K | Q8N0Y2 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF444 | insertion | Frame_Shift_Ins | rs775285349 | c.310_311insC | p.Asp106ArgfsTer38 | p.D106Rfs*38 | Q8N0Y2 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | ||
ZNF444 | SNV | Missense_Mutation | novel | c.367G>A | p.Ala123Thr | p.A123T | Q8N0Y2 | protein_coding | tolerated(0.56) | benign(0.012) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF444 | SNV | Missense_Mutation | rs759442720 | c.316G>A | p.Asp106Asn | p.D106N | Q8N0Y2 | protein_coding | tolerated(0.32) | benign(0.138) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF444 | SNV | Missense_Mutation | c.358N>T | p.Gly120Cys | p.G120C | Q8N0Y2 | protein_coding | deleterious(0.01) | possibly_damaging(0.894) | TCGA-21-1077-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF444 | SNV | Missense_Mutation | novel | c.355N>A | p.Gln119Lys | p.Q119K | Q8N0Y2 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-68-8251-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
ZNF444 | SNV | Missense_Mutation | novel | c.443G>A | p.Gly148Glu | p.G148E | Q8N0Y2 | protein_coding | tolerated(0.37) | benign(0) | TCGA-CQ-A4CI-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ZNF444 | SNV | Missense_Mutation | novel | c.137G>T | p.Arg46Leu | p.R46L | Q8N0Y2 | protein_coding | tolerated(0.31) | probably_damaging(0.982) | TCGA-CV-7427-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF444 | SNV | Missense_Mutation | novel | c.310N>C | p.Ser104Pro | p.S104P | Q8N0Y2 | protein_coding | tolerated(0.19) | possibly_damaging(0.597) | TCGA-CV-A45Q-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF444 | SNV | Missense_Mutation | novel | c.130C>G | p.Leu44Val | p.L44V | Q8N0Y2 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-QK-A8ZB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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