TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF414 | GDT | Cervix | ADJ | ISG15,LINC00892,IFI27, etc. | 1.33e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZNF414 | CD8TEREX | Cervix | CC | ISG15,LINC00892,IFI27, etc. | 4.74e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF414 | CD8TCM | Cervix | CC | ISG15,LINC00892,IFI27, etc. | 1.04e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF414 | GDT | Cervix | CC | ISG15,LINC00892,IFI27, etc. | 2.01e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF414 | CD8TEXINT | Cervix | CC | ISG15,LINC00892,IFI27, etc. | 1.45e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_CC/regulons_activity_in_dotplot.png) |
ZNF414 | GDT | Cervix | Healthy | ISG15,LINC00892,IFI27, etc. | 2.89e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF414 | CD8TEREX | Cervix | Healthy | ISG15,LINC00892,IFI27, etc. | 3.22e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF414 | CD8TEXINT | Cervix | Healthy | ISG15,LINC00892,IFI27, etc. | 2.28e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF414 | GDT | Cervix | HSIL_HPV | ISG15,LINC00892,IFI27, etc. | 3.42e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_HSIL_HPV/regulons_activity_in_dotplot.png) |
ZNF414 | GDT | Cervix | N_HPV | ISG15,LINC00892,IFI27, etc. | 2.46e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_N_HPV/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF414 | SNV | Missense_Mutation | novel | c.1139N>T | p.Ser380Leu | p.S380L | Q96IQ9 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF414 | SNV | Missense_Mutation | rs763516794 | c.437G>A | p.Arg146His | p.R146H | Q96IQ9 | protein_coding | tolerated(0.28) | probably_damaging(0.989) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
ZNF414 | SNV | Missense_Mutation | rs188164067 | c.304N>T | p.Arg102Cys | p.R102C | Q96IQ9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF414 | SNV | Missense_Mutation | rs762887348 | c.125N>T | p.Ser42Leu | p.S42L | Q96IQ9 | protein_coding | tolerated_low_confidence(0.13) | benign(0) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF414 | SNV | Missense_Mutation | | c.903N>T | p.Gln301His | p.Q301H | Q96IQ9 | protein_coding | tolerated(0.08) | probably_damaging(0.986) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF414 | SNV | Missense_Mutation | | c.542G>A | p.Cys181Tyr | p.C181Y | Q96IQ9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-5868-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
ZNF414 | SNV | Missense_Mutation | novel | c.296C>A | p.Pro99His | p.P99H | Q96IQ9 | protein_coding | deleterious(0.05) | possibly_damaging(0.739) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF414 | SNV | Missense_Mutation | rs762887348 | c.125N>T | p.Ser42Leu | p.S42L | Q96IQ9 | protein_coding | tolerated_low_confidence(0.13) | benign(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF414 | SNV | Missense_Mutation | novel | c.1123N>A | p.Val375Met | p.V375M | Q96IQ9 | protein_coding | tolerated(0.17) | possibly_damaging(0.656) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF414 | SNV | Missense_Mutation | novel | c.477G>A | p.Met159Ile | p.M159I | Q96IQ9 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |