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Gene: ZNF234 |
Gene summary for ZNF234 |
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Gene information | Species | Human | Gene symbol | ZNF234 | Gene ID | 10780 |
Gene name | zinc finger protein 234 | |
Gene Alias | HZF4 | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R0N3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10780 | ZNF234 | HCC1 | Human | Liver | HCC | 5.39e-08 | 1.38e+00 | 0.5336 |
10780 | ZNF234 | HCC2 | Human | Liver | HCC | 2.72e-16 | 1.75e+00 | 0.5341 |
10780 | ZNF234 | HCC5 | Human | Liver | HCC | 4.99e-24 | 2.40e+00 | 0.4932 |
10780 | ZNF234 | S028 | Human | Liver | HCC | 2.21e-02 | 1.42e-01 | 0.2503 |
10780 | ZNF234 | S029 | Human | Liver | HCC | 1.16e-02 | 1.49e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF234 | LYMEND | Stomach | SIM | MTERF1,METTL23,PABPN1, etc. | 5.17e-02 | ![]() |
ZNF234 | ICAF | Stomach | WIM | MTERF1,METTL23,PABPN1, etc. | 3.78e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF234 | SNV | Missense_Mutation | novel | c.90N>T | p.Arg30Ser | p.R30S | Q14588 | protein_coding | deleterious(0) | benign(0.272) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ZNF234 | SNV | Missense_Mutation | c.743N>G | p.Thr248Ser | p.T248S | Q14588 | protein_coding | tolerated(0.67) | benign(0.003) | TCGA-A1-A0SK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF234 | SNV | Missense_Mutation | rs764285863 | c.611N>G | p.Tyr204Cys | p.Y204C | Q14588 | protein_coding | tolerated(0.1) | possibly_damaging(0.893) | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF234 | deletion | Frame_Shift_Del | novel | c.561delN | p.Tyr187Ter | p.Y187* | Q14588 | protein_coding | TCGA-E2-A1LB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ZNF234 | SNV | Missense_Mutation | novel | c.274N>T | p.Ala92Ser | p.A92S | Q14588 | protein_coding | tolerated(0.36) | benign(0.015) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF234 | SNV | Missense_Mutation | c.1003N>G | p.Gln335Glu | p.Q335E | Q14588 | protein_coding | deleterious(0.04) | benign(0.127) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF234 | SNV | Missense_Mutation | c.599G>C | p.Gly200Ala | p.G200A | Q14588 | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF234 | SNV | Missense_Mutation | c.643N>G | p.Gln215Glu | p.Q215E | Q14588 | protein_coding | tolerated(0.09) | benign(0.313) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF234 | SNV | Missense_Mutation | novel | c.687G>T | p.Glu229Asp | p.E229D | Q14588 | protein_coding | tolerated(0.05) | benign(0.249) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF234 | SNV | Missense_Mutation | novel | c.1751N>G | p.Asp584Gly | p.D584G | Q14588 | protein_coding | tolerated(0.34) | possibly_damaging(0.893) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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