![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF121 |
Gene summary for ZNF121 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF121 | Gene ID | 7675 |
Gene name | zinc finger protein 121 | |
Gene Alias | D19S204 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P58317 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7675 | ZNF121 | LZE4T | Human | Esophagus | ESCC | 5.37e-03 | 1.72e-01 | 0.0811 |
7675 | ZNF121 | LZE5T | Human | Esophagus | ESCC | 2.66e-03 | 4.39e-01 | 0.0514 |
7675 | ZNF121 | LZE7T | Human | Esophagus | ESCC | 1.30e-07 | 4.74e-01 | 0.0667 |
7675 | ZNF121 | LZE8T | Human | Esophagus | ESCC | 1.29e-10 | 1.61e-01 | 0.067 |
7675 | ZNF121 | LZE20T | Human | Esophagus | ESCC | 4.75e-05 | -3.80e-03 | 0.0662 |
7675 | ZNF121 | LZE24T | Human | Esophagus | ESCC | 8.57e-15 | 1.84e-01 | 0.0596 |
7675 | ZNF121 | LZE21T | Human | Esophagus | ESCC | 1.80e-03 | 1.54e-01 | 0.0655 |
7675 | ZNF121 | P1T-E | Human | Esophagus | ESCC | 1.26e-06 | 2.86e-01 | 0.0875 |
7675 | ZNF121 | P2T-E | Human | Esophagus | ESCC | 2.93e-15 | 7.81e-03 | 0.1177 |
7675 | ZNF121 | P4T-E | Human | Esophagus | ESCC | 3.27e-13 | 1.58e-01 | 0.1323 |
7675 | ZNF121 | P5T-E | Human | Esophagus | ESCC | 1.08e-11 | 1.36e-01 | 0.1327 |
7675 | ZNF121 | P8T-E | Human | Esophagus | ESCC | 1.69e-24 | 2.95e-01 | 0.0889 |
7675 | ZNF121 | P9T-E | Human | Esophagus | ESCC | 1.91e-06 | 1.20e-01 | 0.1131 |
7675 | ZNF121 | P10T-E | Human | Esophagus | ESCC | 3.38e-19 | 2.94e-01 | 0.116 |
7675 | ZNF121 | P11T-E | Human | Esophagus | ESCC | 1.21e-05 | 1.62e-01 | 0.1426 |
7675 | ZNF121 | P12T-E | Human | Esophagus | ESCC | 1.90e-13 | 1.93e-01 | 0.1122 |
7675 | ZNF121 | P15T-E | Human | Esophagus | ESCC | 6.21e-12 | 5.72e-02 | 0.1149 |
7675 | ZNF121 | P16T-E | Human | Esophagus | ESCC | 1.16e-12 | 4.61e-02 | 0.1153 |
7675 | ZNF121 | P17T-E | Human | Esophagus | ESCC | 9.45e-09 | 2.55e-01 | 0.1278 |
7675 | ZNF121 | P20T-E | Human | Esophagus | ESCC | 2.41e-12 | 1.10e-01 | 0.1124 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF121 | SNV | Missense_Mutation | rs751459507 | c.232N>T | p.His78Tyr | p.H78Y | P58317 | protein_coding | tolerated(1) | benign(0.003) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD |
ZNF121 | SNV | Missense_Mutation | novel | c.956A>T | p.Lys319Ile | p.K319I | P58317 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A576-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
ZNF121 | SNV | Missense_Mutation | c.461N>A | p.Arg154Lys | p.R154K | P58317 | protein_coding | tolerated(0.32) | benign(0.145) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
ZNF121 | SNV | Missense_Mutation | c.1014N>C | p.Lys338Asn | p.K338N | P58317 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF121 | SNV | Missense_Mutation | novel | c.651A>T | p.Lys217Asn | p.K217N | P58317 | protein_coding | tolerated(0.21) | possibly_damaging(0.855) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | rs866277666 | c.659G>A | p.Arg220Gln | p.R220Q | P58317 | protein_coding | tolerated(0.29) | possibly_damaging(0.872) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | novel | c.425A>C | p.Lys142Thr | p.K142T | P58317 | protein_coding | deleterious(0.01) | probably_damaging(0.937) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF121 | SNV | Missense_Mutation | c.1079G>T | p.Arg360Ile | p.R360I | P58317 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF121 | SNV | Missense_Mutation | c.835N>G | p.Thr279Ala | p.T279A | P58317 | protein_coding | deleterious(0.04) | benign(0.179) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF121 | SNV | Missense_Mutation | c.761A>C | p.Lys254Thr | p.K254T | P58317 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |