TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZFP30 | CHO | Liver | HCC | RASSF6,SLC33A1,PIP4K2A, etc. | 4.44e-16 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Liver/Str/TF_HCC/regulons_activity_in_dotplot.png) |
ZFP30 | CD8TEREX | Thyroid | ADJ | COL1A2,COL3A1,YJEFN3, etc. | 8.30e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZFP30 | NKT | Thyroid | ADJ | COL1A2,COL3A1,YJEFN3, etc. | 5.26e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
ZFP30 | NKT | Thyroid | ATC | COL1A2,COL3A1,YJEFN3, etc. | 2.44e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_ATC/regulons_activity_in_dotplot.png) |
ZFP30 | M1MAC | Thyroid | goiters | COL1A2,COL3A1,YJEFN3, etc. | 9.86e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_goiters/regulons_activity_in_dotplot.png) |
ZFP30 | GDT | Thyroid | Healthy | COL1A2,COL3A1,YJEFN3, etc. | 9.72e-03 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZFP30 | TH2 | Thyroid | Healthy | COL1A2,COL3A1,YJEFN3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZFP30 | GC | Thyroid | Healthy | COL1A2,COL3A1,YJEFN3, etc. | 1.52e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZFP30 | pDC | Thyroid | HT | COL1A2,COL3A1,YJEFN3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_HT/regulons_activity_in_dotplot.png) |
ZFP30 | TFH | Thyroid | HT | COL1A2,COL3A1,YJEFN3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Thyroid/Str/TF_HT/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFP30 | SNV | Missense_Mutation | | c.1102N>G | p.His368Asp | p.H368D | Q9Y2G7 | protein_coding | tolerated(0.14) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZFP30 | SNV | Missense_Mutation | novel | c.1491G>C | p.Lys497Asn | p.K497N | Q9Y2G7 | protein_coding | tolerated(0.21) | possibly_damaging(0.745) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
ZFP30 | SNV | Missense_Mutation | | c.433N>G | p.Leu145Val | p.L145V | Q9Y2G7 | protein_coding | tolerated(0.09) | benign(0) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
ZFP30 | SNV | Missense_Mutation | rs370737195 | c.1013G>A | p.Arg338Gln | p.R338Q | Q9Y2G7 | protein_coding | tolerated(0.33) | probably_damaging(0.987) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ZFP30 | SNV | Missense_Mutation | rs769698824 | c.967N>A | p.Glu323Lys | p.E323K | Q9Y2G7 | protein_coding | tolerated(0.09) | probably_damaging(0.996) | TCGA-AR-A1AV-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD |
ZFP30 | SNV | Missense_Mutation | | c.294N>T | p.Met98Ile | p.M98I | Q9Y2G7 | protein_coding | tolerated(1) | benign(0) | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZFP30 | SNV | Missense_Mutation | | c.1089C>A | p.Phe363Leu | p.F363L | Q9Y2G7 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
ZFP30 | insertion | Nonsense_Mutation | novel | c.1266_1267insACATGCTGAATGAC | p.Ser423ThrfsTer3 | p.S423Tfs*3 | Q9Y2G7 | protein_coding | | | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
ZFP30 | insertion | Nonsense_Mutation | novel | c.1036_1037insATAATTATTAAGTTACATTAT | p.Arg346delinsAsnAsnTyrTerValThrLeuTer | p.R346delinsNNY*VTL* | Q9Y2G7 | protein_coding | | | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFP30 | SNV | Missense_Mutation | rs144294637 | c.1541N>A | p.Arg514Gln | p.R514Q | Q9Y2G7 | protein_coding | deleterious(0.03) | benign(0.158) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |