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Gene: ZDHHC4 |
Gene summary for ZDHHC4 |
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Gene information | Species | Human | Gene symbol | ZDHHC4 | Gene ID | 55146 |
Gene name | zinc finger DHHC-type palmitoyltransferase 4 | |
Gene Alias | ZNF374 | |
Cytomap | 7p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024QZS8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55146 | ZDHHC4 | LZE4T | Human | Esophagus | ESCC | 2.06e-12 | 3.23e-01 | 0.0811 |
55146 | ZDHHC4 | LZE5T | Human | Esophagus | ESCC | 1.45e-04 | 3.96e-01 | 0.0514 |
55146 | ZDHHC4 | LZE7T | Human | Esophagus | ESCC | 1.98e-06 | 4.08e-01 | 0.0667 |
55146 | ZDHHC4 | LZE8T | Human | Esophagus | ESCC | 4.14e-05 | 1.64e-01 | 0.067 |
55146 | ZDHHC4 | LZE22T | Human | Esophagus | ESCC | 5.43e-03 | 2.73e-01 | 0.068 |
55146 | ZDHHC4 | LZE24T | Human | Esophagus | ESCC | 2.23e-09 | 1.69e-01 | 0.0596 |
55146 | ZDHHC4 | LZE6T | Human | Esophagus | ESCC | 1.09e-05 | 4.73e-01 | 0.0845 |
55146 | ZDHHC4 | P1T-E | Human | Esophagus | ESCC | 1.10e-09 | 5.41e-01 | 0.0875 |
55146 | ZDHHC4 | P2T-E | Human | Esophagus | ESCC | 6.81e-38 | 6.86e-01 | 0.1177 |
55146 | ZDHHC4 | P4T-E | Human | Esophagus | ESCC | 2.08e-31 | 6.74e-01 | 0.1323 |
55146 | ZDHHC4 | P5T-E | Human | Esophagus | ESCC | 1.54e-10 | 2.67e-01 | 0.1327 |
55146 | ZDHHC4 | P8T-E | Human | Esophagus | ESCC | 1.74e-21 | 4.72e-01 | 0.0889 |
55146 | ZDHHC4 | P9T-E | Human | Esophagus | ESCC | 3.78e-06 | 2.54e-01 | 0.1131 |
55146 | ZDHHC4 | P10T-E | Human | Esophagus | ESCC | 1.05e-41 | 7.50e-01 | 0.116 |
55146 | ZDHHC4 | P11T-E | Human | Esophagus | ESCC | 1.35e-09 | 5.64e-01 | 0.1426 |
55146 | ZDHHC4 | P12T-E | Human | Esophagus | ESCC | 1.18e-34 | 7.15e-01 | 0.1122 |
55146 | ZDHHC4 | P15T-E | Human | Esophagus | ESCC | 4.21e-28 | 5.36e-01 | 0.1149 |
55146 | ZDHHC4 | P16T-E | Human | Esophagus | ESCC | 2.86e-48 | 9.14e-01 | 0.1153 |
55146 | ZDHHC4 | P17T-E | Human | Esophagus | ESCC | 5.15e-06 | 3.41e-01 | 0.1278 |
55146 | ZDHHC4 | P19T-E | Human | Esophagus | ESCC | 8.61e-09 | 9.70e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:00421573 | Esophagus | ESCC | lipoprotein metabolic process | 86/8552 | 135/18723 | 1.78e-05 | 1.57e-04 | 86 |
GO:00064973 | Esophagus | ESCC | protein lipidation | 62/8552 | 92/18723 | 2.08e-05 | 1.80e-04 | 62 |
GO:00421583 | Esophagus | ESCC | lipoprotein biosynthetic process | 64/8552 | 96/18723 | 2.61e-05 | 2.20e-04 | 64 |
GO:00066124 | Esophagus | ESCC | protein targeting to membrane | 83/8552 | 131/18723 | 3.31e-05 | 2.73e-04 | 83 |
GO:00066057 | Liver | Cirrhotic | protein targeting | 148/4634 | 314/18723 | 3.86e-18 | 6.20e-16 | 148 |
GO:00901507 | Liver | Cirrhotic | establishment of protein localization to membrane | 123/4634 | 260/18723 | 1.85e-15 | 2.15e-13 | 123 |
GO:00435431 | Liver | Cirrhotic | protein acylation | 95/4634 | 243/18723 | 4.73e-07 | 1.07e-05 | 95 |
GO:00066122 | Liver | Cirrhotic | protein targeting to membrane | 53/4634 | 131/18723 | 5.17e-05 | 5.95e-04 | 53 |
GO:0042157 | Liver | Cirrhotic | lipoprotein metabolic process | 53/4634 | 135/18723 | 1.32e-04 | 1.29e-03 | 53 |
GO:0042158 | Liver | Cirrhotic | lipoprotein biosynthetic process | 36/4634 | 96/18723 | 3.69e-03 | 2.03e-02 | 36 |
GO:0006497 | Liver | Cirrhotic | protein lipidation | 33/4634 | 92/18723 | 1.12e-02 | 4.92e-02 | 33 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
GO:00435432 | Liver | HCC | protein acylation | 157/7958 | 243/18723 | 2.40e-12 | 1.12e-10 | 157 |
GO:00421571 | Liver | HCC | lipoprotein metabolic process | 86/7958 | 135/18723 | 5.21e-07 | 8.38e-06 | 86 |
GO:00421581 | Liver | HCC | lipoprotein biosynthetic process | 58/7958 | 96/18723 | 2.99e-04 | 2.13e-03 | 58 |
GO:00066121 | Liver | HCC | protein targeting to membrane | 75/7958 | 131/18723 | 4.58e-04 | 3.04e-03 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZDHHC4 | SNV | Missense_Mutation | c.136N>G | p.Pro46Ala | p.P46A | Q9NPG8 | protein_coding | deleterious(0.01) | possibly_damaging(0.862) | TCGA-E2-A14P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | trastuzumab | SD | |
ZDHHC4 | SNV | Missense_Mutation | rs542200111 | c.842C>T | p.Ala281Val | p.A281V | Q9NPG8 | protein_coding | tolerated(0.09) | benign(0.162) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZDHHC4 | SNV | Missense_Mutation | novel | c.236N>C | p.Val79Ala | p.V79A | Q9NPG8 | protein_coding | deleterious(0) | benign(0.283) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZDHHC4 | SNV | Missense_Mutation | novel | c.802T>A | p.Phe268Ile | p.F268I | Q9NPG8 | protein_coding | tolerated(0.17) | benign(0.033) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZDHHC4 | SNV | Missense_Mutation | rs372891853 | c.482N>A | p.Arg161Gln | p.R161Q | Q9NPG8 | protein_coding | deleterious(0.04) | possibly_damaging(0.757) | TCGA-G4-6321-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | SD |
ZDHHC4 | SNV | Missense_Mutation | novel | c.187N>G | p.Thr63Ala | p.T63A | Q9NPG8 | protein_coding | deleterious(0.01) | possibly_damaging(0.817) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZDHHC4 | SNV | Missense_Mutation | c.24N>C | p.Leu8Phe | p.L8F | Q9NPG8 | protein_coding | tolerated(0.06) | benign(0.029) | TCGA-CI-6622-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
ZDHHC4 | SNV | Missense_Mutation | rs774421869 | c.74C>T | p.Ser25Leu | p.S25L | Q9NPG8 | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZDHHC4 | SNV | Missense_Mutation | novel | c.117G>T | p.Gln39His | p.Q39H | Q9NPG8 | protein_coding | deleterious(0) | possibly_damaging(0.707) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZDHHC4 | SNV | Missense_Mutation | c.152G>A | p.Arg51Lys | p.R51K | Q9NPG8 | protein_coding | tolerated(0.09) | possibly_damaging(0.787) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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