GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00004226 | Breast | Precancer | autophagy of mitochondrion | 14/1080 | 81/18723 | 2.01e-04 | 3.16e-03 | 14 |
GO:00617266 | Breast | Precancer | mitochondrion disassembly | 14/1080 | 81/18723 | 2.01e-04 | 3.16e-03 | 14 |
GO:00316679 | Breast | Precancer | response to nutrient levels | 47/1080 | 474/18723 | 2.09e-04 | 3.27e-03 | 47 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:00714969 | Breast | Precancer | cellular response to external stimulus | 33/1080 | 320/18723 | 9.01e-04 | 1.03e-02 | 33 |
GO:00316688 | Breast | Precancer | cellular response to extracellular stimulus | 27/1080 | 246/18723 | 1.02e-03 | 1.13e-02 | 27 |
GO:00092677 | Breast | Precancer | cellular response to starvation | 19/1080 | 156/18723 | 1.65e-03 | 1.67e-02 | 19 |
GO:00425947 | Breast | Precancer | response to starvation | 22/1080 | 197/18723 | 2.30e-03 | 2.15e-02 | 22 |
GO:19030085 | Breast | Precancer | organelle disassembly | 15/1080 | 114/18723 | 2.31e-03 | 2.15e-02 | 15 |
GO:00316697 | Breast | Precancer | cellular response to nutrient levels | 22/1080 | 215/18723 | 6.58e-03 | 4.53e-02 | 22 |
GO:003166714 | Breast | IDC | response to nutrient levels | 62/1434 | 474/18723 | 2.33e-05 | 5.57e-04 | 62 |
GO:007149614 | Breast | IDC | cellular response to external stimulus | 45/1434 | 320/18723 | 5.40e-05 | 1.15e-03 | 45 |
GO:003166814 | Breast | IDC | cellular response to extracellular stimulus | 35/1434 | 246/18723 | 2.79e-04 | 4.26e-03 | 35 |
GO:000042212 | Breast | IDC | autophagy of mitochondrion | 15/1434 | 81/18723 | 1.13e-03 | 1.23e-02 | 15 |
GO:006172612 | Breast | IDC | mitochondrion disassembly | 15/1434 | 81/18723 | 1.13e-03 | 1.23e-02 | 15 |
GO:003166914 | Breast | IDC | cellular response to nutrient levels | 28/1434 | 215/18723 | 4.02e-03 | 3.25e-02 | 28 |
GO:190300812 | Breast | IDC | organelle disassembly | 17/1434 | 114/18723 | 5.99e-03 | 4.31e-02 | 17 |
GO:007149623 | Breast | DCIS | cellular response to external stimulus | 45/1390 | 320/18723 | 2.55e-05 | 5.87e-04 | 45 |
GO:003166723 | Breast | DCIS | response to nutrient levels | 58/1390 | 474/18723 | 1.16e-04 | 2.03e-03 | 58 |
GO:003166822 | Breast | DCIS | cellular response to extracellular stimulus | 35/1390 | 246/18723 | 1.54e-04 | 2.59e-03 | 35 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR4 | SNV | Missense_Mutation | | c.504N>T | p.Lys168Asn | p.K168N | P57081 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A25C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
WDR4 | insertion | Frame_Shift_Ins | novel | c.197_198insCTCCCAAACT | p.Thr68GlnfsTer17 | p.T68Qfs*17 | P57081 | protein_coding | | | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR4 | insertion | In_Frame_Ins | novel | c.195_196insACCTCAGGTGATCCGCTGGCCTCG | p.Leu65_Ala66insThrSerGlyAspProLeuAlaSer | p.L65_A66insTSGDPLAS | P57081 | protein_coding | | | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR4 | insertion | In_Frame_Ins | novel | c.306_307insCCACCTTCCTCTTCGCTGTCCTTCCCTGTG | p.Ala102_Arg103insProProSerSerSerLeuSerPheProVal | p.A102_R103insPPSSSLSFPV | P57081 | protein_coding | | | TCGA-BH-A0HU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
WDR4 | deletion | Frame_Shift_Del | novel | c.735delN | p.Ala246ArgfsTer88 | p.A246Rfs*88 | P57081 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
WDR4 | SNV | Missense_Mutation | rs144346351 | c.238G>A | p.Asp80Asn | p.D80N | P57081 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
WDR4 | SNV | Missense_Mutation | rs543569485 | c.604N>A | p.Gly202Arg | p.G202R | P57081 | protein_coding | tolerated(0.16) | benign(0.021) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
WDR4 | SNV | Missense_Mutation | novel | c.1096G>A | p.Asp366Asn | p.D366N | P57081 | protein_coding | deleterious(0.01) | probably_damaging(0.924) | TCGA-AA-A02Y-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR4 | SNV | Missense_Mutation | | c.14T>C | p.Val5Ala | p.V5A | P57081 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-D5-5539-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fu | PD |
WDR4 | deletion | Frame_Shift_Del | | c.724delN | p.Gln242ArgfsTer92 | p.Q242Rfs*92 | P57081 | protein_coding | | | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |