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Gene: TSPAN4 |
Gene summary for TSPAN4 |
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Gene information | Species | Human | Gene symbol | TSPAN4 | Gene ID | 7106 |
Gene name | tetraspanin 4 | |
Gene Alias | NAG-2 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024RCE1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7106 | TSPAN4 | LZE24T | Human | Esophagus | ESCC | 8.01e-09 | 2.47e-01 | 0.0596 |
7106 | TSPAN4 | P2T-E | Human | Esophagus | ESCC | 1.36e-37 | 7.56e-01 | 0.1177 |
7106 | TSPAN4 | P4T-E | Human | Esophagus | ESCC | 4.08e-09 | 3.77e-01 | 0.1323 |
7106 | TSPAN4 | P8T-E | Human | Esophagus | ESCC | 2.78e-09 | 3.84e-01 | 0.0889 |
7106 | TSPAN4 | P9T-E | Human | Esophagus | ESCC | 1.54e-10 | 5.15e-01 | 0.1131 |
7106 | TSPAN4 | P10T-E | Human | Esophagus | ESCC | 4.83e-15 | 4.52e-01 | 0.116 |
7106 | TSPAN4 | P11T-E | Human | Esophagus | ESCC | 1.49e-13 | 6.13e-01 | 0.1426 |
7106 | TSPAN4 | P12T-E | Human | Esophagus | ESCC | 6.23e-07 | 1.61e-01 | 0.1122 |
7106 | TSPAN4 | P15T-E | Human | Esophagus | ESCC | 1.29e-04 | 2.18e-01 | 0.1149 |
7106 | TSPAN4 | P16T-E | Human | Esophagus | ESCC | 1.81e-19 | 3.63e-01 | 0.1153 |
7106 | TSPAN4 | P17T-E | Human | Esophagus | ESCC | 1.24e-10 | 3.87e-01 | 0.1278 |
7106 | TSPAN4 | P19T-E | Human | Esophagus | ESCC | 3.04e-02 | 3.81e-01 | 0.1662 |
7106 | TSPAN4 | P21T-E | Human | Esophagus | ESCC | 6.29e-27 | 6.50e-01 | 0.1617 |
7106 | TSPAN4 | P22T-E | Human | Esophagus | ESCC | 2.68e-12 | 3.18e-01 | 0.1236 |
7106 | TSPAN4 | P23T-E | Human | Esophagus | ESCC | 3.47e-03 | 3.06e-01 | 0.108 |
7106 | TSPAN4 | P24T-E | Human | Esophagus | ESCC | 2.39e-09 | 3.01e-01 | 0.1287 |
7106 | TSPAN4 | P26T-E | Human | Esophagus | ESCC | 1.09e-12 | 1.58e-01 | 0.1276 |
7106 | TSPAN4 | P32T-E | Human | Esophagus | ESCC | 3.78e-28 | 5.92e-01 | 0.1666 |
7106 | TSPAN4 | P36T-E | Human | Esophagus | ESCC | 1.38e-07 | 2.99e-01 | 0.1187 |
7106 | TSPAN4 | P37T-E | Human | Esophagus | ESCC | 2.74e-14 | 3.67e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSPAN4 | SNV | Missense_Mutation | novel | c.503N>T | p.Ser168Phe | p.S168F | O14817 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-OL-A5D7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
TSPAN4 | SNV | Missense_Mutation | rs766986570 | c.574N>A | p.Glu192Lys | p.E192K | O14817 | protein_coding | deleterious(0.01) | possibly_damaging(0.876) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TSPAN4 | SNV | Missense_Mutation | c.113N>G | p.Gln38Arg | p.Q38R | O14817 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
TSPAN4 | SNV | Missense_Mutation | novel | c.268N>A | p.Leu90Met | p.L90M | O14817 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4323-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | PD |
TSPAN4 | SNV | Missense_Mutation | rs367776539 | c.409G>A | p.Ala137Thr | p.A137T | O14817 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN4 | SNV | Missense_Mutation | rs537993639 | c.541N>A | p.Ala181Thr | p.A181T | O14817 | protein_coding | tolerated(0.3) | benign(0.025) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN4 | SNV | Missense_Mutation | rs201418035 | c.638C>T | p.Ala213Val | p.A213V | O14817 | protein_coding | tolerated(0.3) | benign(0.009) | TCGA-BS-A0TJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN4 | SNV | Missense_Mutation | c.119N>A | p.Ser40Asn | p.S40N | O14817 | protein_coding | tolerated(1) | benign(0.001) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TSPAN4 | SNV | Missense_Mutation | rs369027951 | c.488N>T | p.Thr163Met | p.T163M | O14817 | protein_coding | deleterious(0.03) | possibly_damaging(0.86) | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSPAN4 | SNV | Missense_Mutation | rs367776539 | c.409G>A | p.Ala137Thr | p.A137T | O14817 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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