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Gene: TOX4 |
Gene summary for TOX4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TOX4 | Gene ID | 9878 |
Gene name | TOX high mobility group box family member 4 | |
Gene Alias | C14orf92 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O94842 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9878 | TOX4 | LZE4T | Human | Esophagus | ESCC | 6.30e-26 | 7.80e-01 | 0.0811 |
9878 | TOX4 | LZE5T | Human | Esophagus | ESCC | 4.59e-02 | 5.75e-01 | 0.0514 |
9878 | TOX4 | LZE7T | Human | Esophagus | ESCC | 1.14e-07 | 2.12e-01 | 0.0667 |
9878 | TOX4 | LZE8T | Human | Esophagus | ESCC | 2.11e-13 | 3.82e-01 | 0.067 |
9878 | TOX4 | LZE20T | Human | Esophagus | ESCC | 1.89e-09 | 4.23e-01 | 0.0662 |
9878 | TOX4 | LZE22D1 | Human | Esophagus | HGIN | 1.01e-03 | -2.10e-02 | 0.0595 |
9878 | TOX4 | LZE24T | Human | Esophagus | ESCC | 1.31e-23 | 7.24e-01 | 0.0596 |
9878 | TOX4 | LZE21T | Human | Esophagus | ESCC | 1.10e-08 | 3.26e-01 | 0.0655 |
9878 | TOX4 | LZE6T | Human | Esophagus | ESCC | 1.88e-07 | 3.01e-01 | 0.0845 |
9878 | TOX4 | P1T-E | Human | Esophagus | ESCC | 9.13e-11 | 6.60e-01 | 0.0875 |
9878 | TOX4 | P2T-E | Human | Esophagus | ESCC | 6.70e-45 | 7.61e-01 | 0.1177 |
9878 | TOX4 | P4T-E | Human | Esophagus | ESCC | 3.19e-37 | 9.44e-01 | 0.1323 |
9878 | TOX4 | P5T-E | Human | Esophagus | ESCC | 7.53e-30 | 5.50e-01 | 0.1327 |
9878 | TOX4 | P8T-E | Human | Esophagus | ESCC | 3.79e-50 | 8.14e-01 | 0.0889 |
9878 | TOX4 | P9T-E | Human | Esophagus | ESCC | 4.39e-28 | 5.67e-01 | 0.1131 |
9878 | TOX4 | P10T-E | Human | Esophagus | ESCC | 1.60e-34 | 6.26e-01 | 0.116 |
9878 | TOX4 | P11T-E | Human | Esophagus | ESCC | 7.95e-13 | 7.71e-01 | 0.1426 |
9878 | TOX4 | P12T-E | Human | Esophagus | ESCC | 1.72e-72 | 1.28e+00 | 0.1122 |
9878 | TOX4 | P15T-E | Human | Esophagus | ESCC | 7.74e-68 | 1.42e+00 | 0.1149 |
9878 | TOX4 | P16T-E | Human | Esophagus | ESCC | 1.73e-33 | 5.69e-01 | 0.1153 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | |
Lung | IAC | |
Lung | AIS | |
Lung | AAH | |
Lung | MIAC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOX4 | SNV | Missense_Mutation | novel | c.703N>T | p.Arg235Cys | p.R235C | O94842 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TOX4 | SNV | Missense_Mutation | novel | c.1325N>T | p.Arg442Leu | p.R442L | O94842 | protein_coding | tolerated(0.5) | benign(0.4) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TOX4 | SNV | Missense_Mutation | c.179N>T | p.Asp60Val | p.D60V | O94842 | protein_coding | deleterious(0.02) | possibly_damaging(0.767) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
TOX4 | SNV | Missense_Mutation | c.1849G>A | p.Val617Met | p.V617M | O94842 | protein_coding | tolerated(0.24) | probably_damaging(0.969) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
TOX4 | SNV | Missense_Mutation | c.1402C>G | p.Pro468Ala | p.P468A | O94842 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
TOX4 | SNV | Missense_Mutation | rs775810291 | c.962N>A | p.Thr321Asn | p.T321N | O94842 | protein_coding | tolerated(0.52) | benign(0.133) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
TOX4 | insertion | Nonsense_Mutation | novel | c.804_805insTTTAGTGTTTAATT | p.Lys269PhefsTer4 | p.K269Ffs*4 | O94842 | protein_coding | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
TOX4 | deletion | Frame_Shift_Del | c.1665_1672delNNNNNNNN | p.Val556GlyfsTer20 | p.V556Gfs*20 | O94842 | protein_coding | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |||
TOX4 | SNV | Missense_Mutation | novel | c.1261C>T | p.Arg421Trp | p.R421W | O94842 | protein_coding | tolerated(0.14) | possibly_damaging(0.853) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TOX4 | SNV | Missense_Mutation | c.1639N>A | p.Glu547Lys | p.E547K | O94842 | protein_coding | deleterious(0.03) | benign(0.114) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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