![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMIGD1 |
Gene summary for TMIGD1 |
![]() |
Gene information | Species | Human | Gene symbol | TMIGD1 | Gene ID | 388364 |
Gene name | transmembrane and immunoglobulin domain containing 1 | |
Gene Alias | TMIGD | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q6UXZ0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
388364 | TMIGD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.65e-03 | 4.23e-01 | -0.1954 |
388364 | TMIGD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.11e-06 | 8.38e-01 | -0.2061 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090559 | Colorectum | AD | regulation of membrane permeability | 31/3918 | 78/18723 | 1.16e-04 | 1.72e-03 | 31 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMIGD1 | SNV | Missense_Mutation | rs369779845 | c.23N>C | p.Ile8Thr | p.I8T | Q6UXZ0 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-A7-A3J0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrazole | SD |
TMIGD1 | SNV | Missense_Mutation | c.251C>A | p.Ser84Tyr | p.S84Y | Q6UXZ0 | protein_coding | deleterious(0.03) | possibly_damaging(0.832) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMIGD1 | SNV | Missense_Mutation | rs768181695 | c.331G>A | p.Val111Met | p.V111M | Q6UXZ0 | protein_coding | tolerated(0.12) | benign(0.371) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMIGD1 | SNV | Missense_Mutation | novel | c.440N>T | p.Ala147Val | p.A147V | Q6UXZ0 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMIGD1 | SNV | Missense_Mutation | novel | c.233N>A | p.Ser78Tyr | p.S78Y | Q6UXZ0 | protein_coding | deleterious(0) | possibly_damaging(0.574) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMIGD1 | SNV | Missense_Mutation | c.481C>A | p.Leu161Ile | p.L161I | Q6UXZ0 | protein_coding | tolerated(1) | benign(0.005) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TMIGD1 | SNV | Missense_Mutation | c.362N>C | p.Phe121Ser | p.F121S | Q6UXZ0 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMIGD1 | SNV | Missense_Mutation | c.481N>A | p.Leu161Ile | p.L161I | Q6UXZ0 | protein_coding | tolerated(1) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMIGD1 | SNV | Missense_Mutation | rs748902182 | c.337G>A | p.Val113Ile | p.V113I | Q6UXZ0 | protein_coding | tolerated(0.8) | benign(0.006) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TMIGD1 | SNV | Missense_Mutation | novel | c.608C>T | p.Thr203Met | p.T203M | Q6UXZ0 | protein_coding | tolerated(0.16) | benign(0.115) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |