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Gene: TMEM65 |
Gene summary for TMEM65 |
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Gene information | Species | Human | Gene symbol | TMEM65 | Gene ID | 157378 |
Gene name | transmembrane protein 65 | |
Gene Alias | TMEM65 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q6PI78 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
157378 | TMEM65 | N_HPV_2 | Human | Cervix | N_HPV | 3.75e-02 | 2.93e-02 | -0.0131 |
157378 | TMEM65 | CCI_1 | Human | Cervix | CC | 4.94e-07 | 6.56e-01 | 0.528 |
157378 | TMEM65 | CCI_2 | Human | Cervix | CC | 3.31e-08 | 1.18e+00 | 0.5249 |
157378 | TMEM65 | LZE20T | Human | Esophagus | ESCC | 7.47e-04 | 2.36e-01 | 0.0662 |
157378 | TMEM65 | LZE24T | Human | Esophagus | ESCC | 9.08e-05 | 1.12e-01 | 0.0596 |
157378 | TMEM65 | P1T-E | Human | Esophagus | ESCC | 1.43e-05 | 1.56e-01 | 0.0875 |
157378 | TMEM65 | P2T-E | Human | Esophagus | ESCC | 1.14e-14 | 1.80e-01 | 0.1177 |
157378 | TMEM65 | P4T-E | Human | Esophagus | ESCC | 4.51e-08 | 2.01e-01 | 0.1323 |
157378 | TMEM65 | P5T-E | Human | Esophagus | ESCC | 1.10e-09 | 1.59e-01 | 0.1327 |
157378 | TMEM65 | P8T-E | Human | Esophagus | ESCC | 2.03e-05 | 8.04e-02 | 0.0889 |
157378 | TMEM65 | P9T-E | Human | Esophagus | ESCC | 1.27e-08 | 6.95e-02 | 0.1131 |
157378 | TMEM65 | P10T-E | Human | Esophagus | ESCC | 4.66e-05 | 7.59e-02 | 0.116 |
157378 | TMEM65 | P12T-E | Human | Esophagus | ESCC | 6.33e-13 | 2.01e-01 | 0.1122 |
157378 | TMEM65 | P15T-E | Human | Esophagus | ESCC | 7.53e-10 | 9.18e-02 | 0.1149 |
157378 | TMEM65 | P16T-E | Human | Esophagus | ESCC | 2.96e-07 | 5.60e-02 | 0.1153 |
157378 | TMEM65 | P17T-E | Human | Esophagus | ESCC | 3.45e-02 | 1.08e-01 | 0.1278 |
157378 | TMEM65 | P20T-E | Human | Esophagus | ESCC | 4.60e-02 | 2.24e-02 | 0.1124 |
157378 | TMEM65 | P21T-E | Human | Esophagus | ESCC | 3.82e-03 | 3.49e-02 | 0.1617 |
157378 | TMEM65 | P22T-E | Human | Esophagus | ESCC | 3.88e-09 | 4.49e-02 | 0.1236 |
157378 | TMEM65 | P23T-E | Human | Esophagus | ESCC | 5.17e-16 | 3.16e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00613374 | Cervix | N_HPV | cardiac conduction | 8/534 | 98/18723 | 6.94e-03 | 4.59e-02 | 8 |
GO:19035222 | Lung | IAC | regulation of blood circulation | 43/2061 | 256/18723 | 3.18e-03 | 2.77e-02 | 43 |
GO:00032055 | Thyroid | PTC | cardiac chamber development | 72/5968 | 161/18723 | 4.13e-04 | 2.77e-03 | 72 |
GO:00032314 | Thyroid | PTC | cardiac ventricle development | 55/5968 | 123/18723 | 1.87e-03 | 1.01e-02 | 55 |
GO:000320512 | Thyroid | ATC | cardiac chamber development | 79/6293 | 161/18723 | 3.39e-05 | 2.80e-04 | 79 |
GO:000323111 | Thyroid | ATC | cardiac ventricle development | 58/6293 | 123/18723 | 1.23e-03 | 6.46e-03 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM65 | SNV | Missense_Mutation | c.697N>C | p.Asp233His | p.D233H | Q6PI78 | protein_coding | deleterious(0.01) | possibly_damaging(0.754) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM65 | SNV | Missense_Mutation | c.404T>G | p.Ile135Ser | p.I135S | Q6PI78 | protein_coding | tolerated(0.06) | benign(0.067) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TMEM65 | SNV | Missense_Mutation | rs146112743 | c.365N>T | p.Ala122Val | p.A122V | Q6PI78 | protein_coding | tolerated(0.05) | probably_damaging(0.996) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM65 | SNV | Missense_Mutation | rs779556138 | c.604N>T | p.Arg202Cys | p.R202C | Q6PI78 | protein_coding | deleterious(0) | benign(0.165) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM65 | SNV | Missense_Mutation | novel | c.575C>T | p.Thr192Ile | p.T192I | Q6PI78 | protein_coding | deleterious(0) | possibly_damaging(0.724) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM65 | SNV | Missense_Mutation | novel | c.488N>C | p.Asn163Thr | p.N163T | Q6PI78 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
TMEM65 | SNV | Missense_Mutation | c.470C>T | p.Ala157Val | p.A157V | Q6PI78 | protein_coding | deleterious(0) | benign(0.405) | TCGA-AX-A05Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TMEM65 | SNV | Missense_Mutation | novel | c.703N>C | p.Lys235Gln | p.K235Q | Q6PI78 | protein_coding | deleterious(0.04) | probably_damaging(0.994) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TMEM65 | SNV | Missense_Mutation | c.587N>G | p.Val196Gly | p.V196G | Q6PI78 | protein_coding | deleterious(0.01) | benign(0.341) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM65 | SNV | Missense_Mutation | c.490N>G | p.Leu164Val | p.L164V | Q6PI78 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BG-A0M8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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