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Gene: TMEM223 |
Gene summary for TMEM223 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM223 | Gene ID | 79064 |
Gene name | transmembrane protein 223 | |
Gene Alias | TMEM223 | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | A0PJW6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79064 | TMEM223 | LZE2T | Human | Esophagus | ESCC | 1.44e-08 | 6.22e-01 | 0.082 |
79064 | TMEM223 | LZE4T | Human | Esophagus | ESCC | 1.08e-05 | 2.62e-01 | 0.0811 |
79064 | TMEM223 | LZE5T | Human | Esophagus | ESCC | 2.30e-07 | 4.41e-01 | 0.0514 |
79064 | TMEM223 | LZE7T | Human | Esophagus | ESCC | 3.68e-10 | 5.60e-01 | 0.0667 |
79064 | TMEM223 | LZE8T | Human | Esophagus | ESCC | 1.71e-03 | 1.81e-01 | 0.067 |
79064 | TMEM223 | LZE20T | Human | Esophagus | ESCC | 1.38e-03 | 2.08e-01 | 0.0662 |
79064 | TMEM223 | LZE22T | Human | Esophagus | ESCC | 6.93e-04 | 3.67e-01 | 0.068 |
79064 | TMEM223 | LZE24T | Human | Esophagus | ESCC | 4.24e-19 | 5.86e-01 | 0.0596 |
79064 | TMEM223 | LZE21T | Human | Esophagus | ESCC | 3.21e-03 | 2.71e-01 | 0.0655 |
79064 | TMEM223 | LZE6T | Human | Esophagus | ESCC | 2.20e-04 | 4.17e-01 | 0.0845 |
79064 | TMEM223 | P1T-E | Human | Esophagus | ESCC | 3.22e-04 | 2.92e-01 | 0.0875 |
79064 | TMEM223 | P2T-E | Human | Esophagus | ESCC | 2.82e-24 | 4.86e-01 | 0.1177 |
79064 | TMEM223 | P4T-E | Human | Esophagus | ESCC | 2.11e-51 | 1.24e+00 | 0.1323 |
79064 | TMEM223 | P5T-E | Human | Esophagus | ESCC | 1.76e-38 | 7.80e-01 | 0.1327 |
79064 | TMEM223 | P8T-E | Human | Esophagus | ESCC | 1.97e-29 | 5.99e-01 | 0.0889 |
79064 | TMEM223 | P9T-E | Human | Esophagus | ESCC | 1.81e-27 | 6.34e-01 | 0.1131 |
79064 | TMEM223 | P10T-E | Human | Esophagus | ESCC | 2.86e-23 | 3.94e-01 | 0.116 |
79064 | TMEM223 | P11T-E | Human | Esophagus | ESCC | 2.47e-13 | 7.63e-01 | 0.1426 |
79064 | TMEM223 | P12T-E | Human | Esophagus | ESCC | 3.15e-38 | 7.14e-01 | 0.1122 |
79064 | TMEM223 | P15T-E | Human | Esophagus | ESCC | 1.21e-24 | 3.42e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | |
Lung | IAC | |
Lung | AIS | |
Lung | AAH | |
Lung | MIAC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM223 | SNV | Missense_Mutation | c.112N>C | p.Glu38Gln | p.E38Q | A0PJW6 | protein_coding | tolerated(0.27) | benign(0.067) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM223 | SNV | Missense_Mutation | rs763596886 | c.478N>T | p.Arg160Trp | p.R160W | A0PJW6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A3GM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM223 | insertion | Frame_Shift_Ins | novel | c.212dupC | p.Val72GlyfsTer91 | p.V72Gfs*91 | A0PJW6 | protein_coding | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
TMEM223 | SNV | Missense_Mutation | rs756262183 | c.127N>T | p.Arg43Cys | p.R43C | A0PJW6 | protein_coding | deleterious(0) | benign(0.054) | TCGA-AZ-5403-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TMEM223 | SNV | Missense_Mutation | novel | c.106C>T | p.Leu36Phe | p.L36F | A0PJW6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM223 | SNV | Missense_Mutation | c.548N>A | p.Thr183Asn | p.T183N | A0PJW6 | protein_coding | tolerated(0.34) | benign(0.026) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM223 | SNV | Missense_Mutation | c.532N>G | p.Phe178Val | p.F178V | A0PJW6 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM223 | SNV | Missense_Mutation | novel | c.340N>G | p.Leu114Val | p.L114V | A0PJW6 | protein_coding | tolerated(0.14) | benign(0.046) | TCGA-DD-AADN-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM223 | SNV | Missense_Mutation | rs771984852 | c.41N>T | p.Ala14Val | p.A14V | A0PJW6 | protein_coding | tolerated_low_confidence(0.52) | benign(0.001) | TCGA-55-8207-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM223 | SNV | Missense_Mutation | c.386G>T | p.Gly129Val | p.G129V | A0PJW6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-69-7765-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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