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Gene: TMEM186 |
Gene summary for TMEM186 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM186 | Gene ID | 25880 |
Gene name | transmembrane protein 186 | |
Gene Alias | C16orf51 | |
Cytomap | 16p13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96B77 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25880 | TMEM186 | LZE4T | Human | Esophagus | ESCC | 6.07e-03 | 8.16e-02 | 0.0811 |
25880 | TMEM186 | LZE7T | Human | Esophagus | ESCC | 3.11e-02 | 1.19e-01 | 0.0667 |
25880 | TMEM186 | LZE24T | Human | Esophagus | ESCC | 3.55e-11 | 1.32e-01 | 0.0596 |
25880 | TMEM186 | P2T-E | Human | Esophagus | ESCC | 4.52e-15 | 3.12e-01 | 0.1177 |
25880 | TMEM186 | P4T-E | Human | Esophagus | ESCC | 9.81e-15 | 2.21e-01 | 0.1323 |
25880 | TMEM186 | P5T-E | Human | Esophagus | ESCC | 2.24e-08 | 1.49e-01 | 0.1327 |
25880 | TMEM186 | P8T-E | Human | Esophagus | ESCC | 1.10e-04 | 1.31e-01 | 0.0889 |
25880 | TMEM186 | P9T-E | Human | Esophagus | ESCC | 1.87e-06 | 1.10e-01 | 0.1131 |
25880 | TMEM186 | P10T-E | Human | Esophagus | ESCC | 5.53e-08 | 1.07e-01 | 0.116 |
25880 | TMEM186 | P11T-E | Human | Esophagus | ESCC | 3.65e-09 | 3.37e-01 | 0.1426 |
25880 | TMEM186 | P12T-E | Human | Esophagus | ESCC | 3.09e-10 | 2.28e-01 | 0.1122 |
25880 | TMEM186 | P15T-E | Human | Esophagus | ESCC | 8.14e-09 | 1.58e-01 | 0.1149 |
25880 | TMEM186 | P16T-E | Human | Esophagus | ESCC | 1.05e-17 | 2.41e-01 | 0.1153 |
25880 | TMEM186 | P20T-E | Human | Esophagus | ESCC | 1.63e-08 | 2.40e-01 | 0.1124 |
25880 | TMEM186 | P21T-E | Human | Esophagus | ESCC | 6.00e-23 | 3.36e-01 | 0.1617 |
25880 | TMEM186 | P22T-E | Human | Esophagus | ESCC | 1.10e-18 | 2.60e-01 | 0.1236 |
25880 | TMEM186 | P23T-E | Human | Esophagus | ESCC | 3.87e-11 | 2.78e-01 | 0.108 |
25880 | TMEM186 | P24T-E | Human | Esophagus | ESCC | 1.30e-11 | 1.78e-01 | 0.1287 |
25880 | TMEM186 | P26T-E | Human | Esophagus | ESCC | 1.24e-16 | 2.24e-01 | 0.1276 |
25880 | TMEM186 | P27T-E | Human | Esophagus | ESCC | 1.17e-12 | 1.06e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | |
Lung | IAC | |
Lung | AIS | |
Lung | AAH | |
Lung | MIAC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM186 | SNV | Missense_Mutation | novel | c.344C>A | p.Thr115Asn | p.T115N | Q96B77 | protein_coding | deleterious(0.01) | benign(0.192) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
TMEM186 | insertion | In_Frame_Ins | novel | c.408_409insACTGAAAATACAAAAATTAGCTGGGCATGGTGGTGG | p.Ser136_Gly137insThrGluAsnThrLysIleSerTrpAlaTrpTrpTrp | p.S136_G137insTENTKISWAWWW | Q96B77 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
TMEM186 | insertion | Nonsense_Mutation | novel | c.183_184insATACCCATTGAGCAATAATTTCCTTCTTTTTCCAGCCCTTGGCAAC | p.Phe62IlefsTer6 | p.F62Ifs*6 | Q96B77 | protein_coding | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TMEM186 | insertion | Frame_Shift_Ins | novel | c.349_350insAGGAGATCGAGGCCATCCTCGCTAACAGGGTGAAACCG | p.Leu117GlnfsTer17 | p.L117Qfs*17 | Q96B77 | protein_coding | TCGA-BH-A0HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
TMEM186 | SNV | Missense_Mutation | rs140742433 | c.583N>T | p.Arg195Cys | p.R195C | Q96B77 | protein_coding | deleterious(0.02) | benign(0.011) | TCGA-AA-3494-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PR |
TMEM186 | SNV | Missense_Mutation | novel | c.31T>G | p.Phe11Val | p.F11V | Q96B77 | protein_coding | tolerated_low_confidence(0.12) | benign(0.023) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM186 | SNV | Missense_Mutation | rs755239323 | c.530G>A | p.Arg177His | p.R177H | Q96B77 | protein_coding | deleterious(0.01) | possibly_damaging(0.809) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM186 | SNV | Missense_Mutation | novel | c.162N>T | p.Glu54Asp | p.E54D | Q96B77 | protein_coding | tolerated(0.11) | benign(0.339) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM186 | SNV | Missense_Mutation | rs778794843 | c.509N>A | p.Arg170Gln | p.R170Q | Q96B77 | protein_coding | tolerated(0.54) | benign(0.003) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TMEM186 | SNV | Missense_Mutation | novel | c.104N>T | p.Arg35Met | p.R35M | Q96B77 | protein_coding | deleterious(0.03) | probably_damaging(0.943) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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