GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00194396 | Liver | NAFLD | aromatic compound catabolic process | 102/1882 | 467/18723 | 2.29e-14 | 1.91e-11 | 102 |
GO:19013616 | Liver | NAFLD | organic cyclic compound catabolic process | 105/1882 | 495/18723 | 7.04e-14 | 5.15e-11 | 105 |
GO:00442707 | Liver | NAFLD | cellular nitrogen compound catabolic process | 93/1882 | 451/18723 | 1.04e-11 | 4.34e-09 | 93 |
GO:00467006 | Liver | NAFLD | heterocycle catabolic process | 92/1882 | 445/18723 | 1.16e-11 | 4.52e-09 | 92 |
GO:00108765 | Liver | NAFLD | lipid localization | 79/1882 | 448/18723 | 4.75e-07 | 2.92e-05 | 79 |
GO:00068694 | Liver | NAFLD | lipid transport | 71/1882 | 398/18723 | 1.16e-06 | 5.59e-05 | 71 |
GO:0015850 | Liver | NAFLD | organic hydroxy compound transport | 50/1882 | 284/18723 | 6.01e-05 | 1.32e-03 | 50 |
GO:0015721 | Liver | NAFLD | bile acid and bile salt transport | 10/1882 | 30/18723 | 4.67e-04 | 6.74e-03 | 10 |
GO:190136111 | Liver | Cirrhotic | organic cyclic compound catabolic process | 213/4634 | 495/18723 | 1.58e-19 | 3.67e-17 | 213 |
GO:001943911 | Liver | Cirrhotic | aromatic compound catabolic process | 202/4634 | 467/18723 | 6.93e-19 | 1.28e-16 | 202 |
GO:004427011 | Liver | Cirrhotic | cellular nitrogen compound catabolic process | 195/4634 | 451/18723 | 2.99e-18 | 4.94e-16 | 195 |
GO:004670011 | Liver | Cirrhotic | heterocycle catabolic process | 192/4634 | 445/18723 | 7.17e-18 | 1.12e-15 | 192 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:0006787 | Liver | Cirrhotic | porphyrin-containing compound catabolic process | 8/4634 | 12/18723 | 2.59e-03 | 1.53e-02 | 8 |
GO:0033015 | Liver | Cirrhotic | tetrapyrrole catabolic process | 8/4634 | 12/18723 | 2.59e-03 | 1.53e-02 | 8 |
GO:0033013 | Liver | Cirrhotic | tetrapyrrole metabolic process | 24/4634 | 59/18723 | 5.06e-03 | 2.62e-02 | 24 |
GO:0042167 | Liver | Cirrhotic | heme catabolic process | 7/4634 | 11/18723 | 7.11e-03 | 3.41e-02 | 7 |
GO:0046149 | Liver | Cirrhotic | pigment catabolic process | 7/4634 | 11/18723 | 7.11e-03 | 3.41e-02 | 7 |
GO:0006778 | Liver | Cirrhotic | porphyrin-containing compound metabolic process | 20/4634 | 49/18723 | 9.60e-03 | 4.35e-02 | 20 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLCO1B1 | SNV | Missense_Mutation | | c.473T>C | p.Val158Ala | p.V158A | Q9Y6L6 | protein_coding | tolerated(0.17) | benign(0.055) | TCGA-A7-A0D9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
SLCO1B1 | SNV | Missense_Mutation | rs138965366 | c.541N>T | p.Arg181Cys | p.R181C | Q9Y6L6 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLCO1B1 | SNV | Missense_Mutation | rs748860610 | c.1828C>T | p.Arg610Cys | p.R610C | Q9Y6L6 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLCO1B1 | SNV | Missense_Mutation | rs758561937 | c.65G>C | p.Arg22Thr | p.R22T | Q9Y6L6 | protein_coding | tolerated(0.14) | benign(0.017) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
SLCO1B1 | SNV | Missense_Mutation | | c.1591N>G | p.Thr531Ala | p.T531A | Q9Y6L6 | protein_coding | tolerated(0.22) | benign(0.01) | TCGA-D8-A1XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide+tamoxifen | SD |
SLCO1B1 | SNV | Missense_Mutation | | c.1780C>G | p.Leu594Val | p.L594V | Q9Y6L6 | protein_coding | tolerated(0.06) | benign(0.344) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
SLCO1B1 | insertion | Frame_Shift_Ins | novel | c.1479_1480insCTCTCTCTTTTTGATATAT | p.Gly494LeufsTer9 | p.G494Lfs*9 | Q9Y6L6 | protein_coding | | | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
SLCO1B1 | insertion | In_Frame_Ins | novel | c.946_947insGGGTCAGCAATG | p.Lys316delinsArgValSerAsnGlu | p.K316delinsRVSNE | Q9Y6L6 | protein_coding | | | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLCO1B1 | SNV | Missense_Mutation | novel | c.1706C>T | p.Ser569Leu | p.S569L | Q9Y6L6 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SLCO1B1 | SNV | Missense_Mutation | novel | c.1755T>G | p.Ile585Met | p.I585M | Q9Y6L6 | protein_coding | tolerated(0.06) | possibly_damaging(0.841) | TCGA-EA-A5ZE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | Rosuvastatin | ROSUVASTATIN | |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | 135650848 | PRAVASTATIN | |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | rocuronium | ROCURONIUM | 25279974 |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | ticagrelor | TICAGRELOR | 25935875 |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | CLOFIBRATE | CLOFIBRATE | 16316932 |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | atrasentan | ATRASENTAN | 16513443 |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | rifampin | RIFAMPIN | 22562052,21709081,24420746,19374892 |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | GEMFIBROZIL | GEMFIBROZIL | 16316932 |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | FENOFIBRATE | FENOFIBRATE | 16316932 |
10599 | SLCO1B1 | TRANSPORTER, DRUGGABLE GENOME | | nateglinide | NATEGLINIDE | 18187595 |