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Gene: SF3A1 |
Gene summary for SF3A1 |
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Gene information | Species | Human | Gene symbol | SF3A1 | Gene ID | 10291 |
Gene name | splicing factor 3a subunit 1 | |
Gene Alias | PRP21 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0000245 | UniProtAcc | A0A024R1K8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10291 | SF3A1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.66e-05 | 3.08e-01 | -0.1808 |
10291 | SF3A1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.32e-06 | 4.35e-01 | -0.0811 |
10291 | SF3A1 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.55e-06 | 4.03e-01 | -0.1088 |
10291 | SF3A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.96e-21 | 5.48e-01 | -0.1954 |
10291 | SF3A1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.38e-02 | 3.06e-01 | -0.1207 |
10291 | SF3A1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.35e-03 | 3.20e-01 | -0.1526 |
10291 | SF3A1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.10e-10 | 3.41e-01 | -0.1464 |
10291 | SF3A1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.39e-06 | 2.77e-01 | -0.1001 |
10291 | SF3A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.92e-11 | 5.00e-01 | -0.059 |
10291 | SF3A1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.81e-02 | 4.42e-01 | -0.1706 |
10291 | SF3A1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 9.31e-03 | 3.77e-01 | -0.1462 |
10291 | SF3A1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.79e-02 | 3.24e-01 | -0.0842 |
10291 | SF3A1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.22e-15 | 4.50e-01 | 0.096 |
10291 | SF3A1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.29e-05 | 4.46e-01 | 0.0528 |
10291 | SF3A1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.17e-04 | 3.67e-01 | 0.0131 |
10291 | SF3A1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.26e-03 | 5.82e-01 | 0.0171 |
10291 | SF3A1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.31e-12 | 4.02e-01 | 0.0674 |
10291 | SF3A1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.94e-03 | 3.30e-01 | 0.0112 |
10291 | SF3A1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 5.87e-03 | 6.08e-01 | -0.0124 |
10291 | SF3A1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.97e-09 | 3.53e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0000245 | Colorectum | AD | spliceosomal complex assembly | 33/3918 | 79/18723 | 2.15e-05 | 4.33e-04 | 33 |
GO:0006376 | Colorectum | AD | mRNA splice site selection | 18/3918 | 49/18723 | 7.93e-03 | 4.73e-02 | 18 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00226181 | Colorectum | SER | ribonucleoprotein complex assembly | 69/2897 | 220/18723 | 2.25e-09 | 2.15e-07 | 69 |
GO:00718261 | Colorectum | SER | ribonucleoprotein complex subunit organization | 70/2897 | 227/18723 | 3.83e-09 | 3.51e-07 | 70 |
GO:00003751 | Colorectum | SER | RNA splicing, via transesterification reactions | 90/2897 | 324/18723 | 8.68e-09 | 7.50e-07 | 90 |
GO:00003771 | Colorectum | SER | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00003981 | Colorectum | SER | mRNA splicing, via spliceosome | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00226131 | Colorectum | SER | ribonucleoprotein complex biogenesis | 112/2897 | 463/18723 | 5.01e-07 | 2.48e-05 | 112 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304026 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
hsa0304036 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
hsa0304025 | Prostate | Tumor | Spliceosome | 66/1791 | 217/8465 | 7.53e-04 | 3.59e-03 | 2.23e-03 | 66 |
hsa0304035 | Prostate | Tumor | Spliceosome | 66/1791 | 217/8465 | 7.53e-04 | 3.59e-03 | 2.23e-03 | 66 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SF3A1 | SNV | Missense_Mutation | novel | c.2005C>A | p.Pro669Thr | p.P669T | Q15459 | protein_coding | tolerated(0.37) | probably_damaging(0.981) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
SF3A1 | SNV | Missense_Mutation | c.1796N>A | p.Arg599Gln | p.R599Q | Q15459 | protein_coding | tolerated(0.68) | possibly_damaging(0.885) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SF3A1 | SNV | Missense_Mutation | c.1229A>G | p.Tyr410Cys | p.Y410C | Q15459 | protein_coding | deleterious(0) | possibly_damaging(0.608) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
SF3A1 | SNV | Missense_Mutation | novel | c.823G>T | p.Asp275Tyr | p.D275Y | Q15459 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-OK-A5Q2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SF3A1 | deletion | Frame_Shift_Del | novel | c.1452delT | p.Ile484MetfsTer17 | p.I484Mfs*17 | Q15459 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SF3A1 | SNV | Missense_Mutation | novel | c.1798N>T | p.Pro600Ser | p.P600S | Q15459 | protein_coding | tolerated(0.08) | benign(0.118) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SF3A1 | SNV | Missense_Mutation | rs377475726 | c.1904N>T | p.Ala635Val | p.A635V | Q15459 | protein_coding | tolerated(0.23) | benign(0.047) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SF3A1 | SNV | Missense_Mutation | c.1497N>T | p.Lys499Asn | p.K499N | Q15459 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SF3A1 | SNV | Missense_Mutation | rs370505540 | c.509N>T | p.Thr170Met | p.T170M | Q15459 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-AA-3980-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SF3A1 | SNV | Missense_Mutation | c.1289G>A | p.Arg430His | p.R430H | Q15459 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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