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Gene: SERPINA11 |
Gene summary for SERPINA11 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SERPINA11 | Gene ID | 256394 |
Gene name | serpin family A member 11 | |
Gene Alias | SERPINA11 | |
Cytomap | 14q32.13 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q86U17 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
256394 | SERPINA11 | NAFLD1 | Human | Liver | NAFLD | 1.07e-05 | 4.51e-01 | -0.04 |
256394 | SERPINA11 | HCC1_Meng | Human | Liver | HCC | 1.34e-06 | -1.59e-02 | 0.0246 |
256394 | SERPINA11 | S014 | Human | Liver | HCC | 1.26e-09 | 5.41e-01 | 0.2254 |
256394 | SERPINA11 | S015 | Human | Liver | HCC | 2.09e-13 | 1.08e+00 | 0.2375 |
256394 | SERPINA11 | S016 | Human | Liver | HCC | 4.05e-03 | 5.37e-01 | 0.2243 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | |
Lung | IAC | |
Lung | AIS | |
Lung | AAH | |
Lung | MIAC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00458617 | Liver | NAFLD | negative regulation of proteolysis | 66/1882 | 351/18723 | 4.02e-07 | 2.58e-05 | 66 |
GO:00513467 | Liver | NAFLD | negative regulation of hydrolase activity | 62/1882 | 379/18723 | 8.11e-05 | 1.66e-03 | 62 |
GO:00525477 | Liver | NAFLD | regulation of peptidase activity | 72/1882 | 461/18723 | 1.03e-04 | 2.03e-03 | 72 |
GO:00525487 | Liver | NAFLD | regulation of endopeptidase activity | 67/1882 | 432/18723 | 2.17e-04 | 3.70e-03 | 67 |
GO:00109517 | Liver | NAFLD | negative regulation of endopeptidase activity | 42/1882 | 252/18723 | 7.29e-04 | 9.29e-03 | 42 |
GO:00104667 | Liver | NAFLD | negative regulation of peptidase activity | 43/1882 | 262/18723 | 8.76e-04 | 1.07e-02 | 43 |
GO:005254722 | Liver | HCC | regulation of peptidase activity | 247/7958 | 461/18723 | 8.28e-07 | 1.27e-05 | 247 |
GO:005254822 | Liver | HCC | regulation of endopeptidase activity | 230/7958 | 432/18723 | 3.58e-06 | 4.68e-05 | 230 |
GO:004586122 | Liver | HCC | negative regulation of proteolysis | 186/7958 | 351/18723 | 4.19e-05 | 4.11e-04 | 186 |
GO:005134622 | Liver | HCC | negative regulation of hydrolase activity | 195/7958 | 379/18723 | 2.44e-04 | 1.82e-03 | 195 |
GO:001095121 | Liver | HCC | negative regulation of endopeptidase activity | 129/7958 | 252/18723 | 3.17e-03 | 1.47e-02 | 129 |
GO:001046621 | Liver | HCC | negative regulation of peptidase activity | 132/7958 | 262/18723 | 5.82e-03 | 2.42e-02 | 132 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SERPINA11 | SNV | Missense_Mutation | novel | c.170N>G | p.Phe57Cys | p.F57C | Q86U17 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SERPINA11 | SNV | Missense_Mutation | rs201110965 | c.577G>A | p.Val193Met | p.V193M | Q86U17 | protein_coding | deleterious(0.03) | benign(0.327) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
SERPINA11 | SNV | Missense_Mutation | rs776283166 | c.179G>A | p.Arg60His | p.R60H | Q86U17 | protein_coding | tolerated(0.06) | benign(0.014) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SERPINA11 | SNV | Missense_Mutation | c.341N>G | p.Asp114Gly | p.D114G | Q86U17 | protein_coding | deleterious(0.01) | probably_damaging(0.933) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SERPINA11 | SNV | Missense_Mutation | c.518N>A | p.Ser173Tyr | p.S173Y | Q86U17 | protein_coding | deleterious(0.03) | possibly_damaging(0.781) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SERPINA11 | SNV | Missense_Mutation | c.222N>A | p.Phe74Leu | p.F74L | Q86U17 | protein_coding | tolerated(0.37) | benign(0.012) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SERPINA11 | SNV | Missense_Mutation | c.1132N>A | p.Leu378Ile | p.L378I | Q86U17 | protein_coding | tolerated(0.34) | benign(0.115) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SERPINA11 | SNV | Missense_Mutation | c.973G>T | p.Asp325Tyr | p.D325Y | Q86U17 | protein_coding | deleterious(0) | possibly_damaging(0.811) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SERPINA11 | SNV | Missense_Mutation | c.832C>G | p.Leu278Val | p.L278V | Q86U17 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DY-A0XA-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | mayo | CR | |
SERPINA11 | SNV | Missense_Mutation | novel | c.60G>T | p.Gln20His | p.Q20H | Q86U17 | protein_coding | tolerated(0.11) | benign(0.04) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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