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Gene: RNF222 |
Gene summary for RNF222 |
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Gene information | Species | Human | Gene symbol | RNF222 | Gene ID | 643904 |
Gene name | ring finger protein 222 | |
Gene Alias | RNF222 | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A6NCQ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
643904 | RNF222 | HCC1 | Human | Liver | HCC | 3.64e-12 | 7.99e-01 | 0.5336 |
643904 | RNF222 | HCC2 | Human | Liver | HCC | 3.00e-28 | 1.28e+00 | 0.5341 |
643904 | RNF222 | HCC5 | Human | Liver | HCC | 2.32e-26 | 1.44e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF222 | SNV | Missense_Mutation | rs554178516 | c.184N>T | p.Pro62Ser | p.P62S | A6NCQ9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A0J5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate | zoledronic | PD |
RNF222 | SNV | Missense_Mutation | rs754991805 | c.79N>A | p.Ala27Thr | p.A27T | A6NCQ9 | protein_coding | tolerated(0.69) | benign(0) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
RNF222 | SNV | Missense_Mutation | rs752923293 | c.199G>A | p.Val67Ile | p.V67I | A6NCQ9 | protein_coding | deleterious(0.01) | possibly_damaging(0.688) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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