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Gene: RAB30-DT |
Gene summary for RAB30-DT |
Gene summary. |
Gene information | Species | Human | Gene symbol | RAB30-DT | Gene ID | 100506233 |
Gene name | RAB30 divergent transcript | |
Gene Alias | RAB30-AS1 | |
Cytomap | 11q14.1 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100506233 | RAB30-DT | LZE2T | Human | Esophagus | ESCC | 1.80e-11 | 1.03e+00 | 0.082 |
100506233 | RAB30-DT | LZE4T | Human | Esophagus | ESCC | 6.35e-03 | 1.21e-01 | 0.0811 |
100506233 | RAB30-DT | LZE7T | Human | Esophagus | ESCC | 3.98e-06 | 2.49e-01 | 0.0667 |
100506233 | RAB30-DT | LZE8T | Human | Esophagus | ESCC | 5.66e-07 | 2.22e-01 | 0.067 |
100506233 | RAB30-DT | LZE20T | Human | Esophagus | ESCC | 4.98e-02 | 1.42e-01 | 0.0662 |
100506233 | RAB30-DT | LZE24T | Human | Esophagus | ESCC | 2.75e-32 | 7.32e-01 | 0.0596 |
100506233 | RAB30-DT | LZE21T | Human | Esophagus | ESCC | 1.16e-05 | 3.00e-01 | 0.0655 |
100506233 | RAB30-DT | LZE6T | Human | Esophagus | ESCC | 2.36e-17 | 6.50e-01 | 0.0845 |
100506233 | RAB30-DT | HTA12-18-3 | Human | Pancreas | PDAC | 1.53e-04 | 5.26e-01 | 0.0716 |
100506233 | RAB30-DT | HTA12-26-1 | Human | Pancreas | PDAC | 4.88e-07 | 3.57e-01 | 0.3728 |
100506233 | RAB30-DT | HTA12-29-1 | Human | Pancreas | PDAC | 2.21e-16 | 3.51e-01 | 0.3722 |
100506233 | RAB30-DT | HTA12-32-1 | Human | Pancreas | PDAC | 4.65e-02 | 5.36e-01 | 0.3624 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | |
Lung | IAC | |
Lung | AIS | |
Lung | AAH | |
Lung | MIAC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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