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Gene: QARS1 |
Gene summary for QARS1 |
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Gene information | Species | Human | Gene symbol | QARS1 | Gene ID | 5859 |
Gene name | glutaminyl-tRNA synthetase 1 | |
Gene Alias | GLNRS | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | B7Z840 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5859 | QARS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.25e-46 | 7.86e-01 | 0.0155 |
5859 | QARS1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.83e-51 | 1.19e+00 | -0.1808 |
5859 | QARS1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.21e-18 | 1.00e+00 | 0.0216 |
5859 | QARS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.67e-41 | 1.01e+00 | -0.0811 |
5859 | QARS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.42e-52 | 1.18e+00 | -0.1088 |
5859 | QARS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.09e-82 | 1.45e+00 | -0.1954 |
5859 | QARS1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.87e-32 | 1.69e+00 | -0.2602 |
5859 | QARS1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.67e-17 | 9.81e-01 | -0.2196 |
5859 | QARS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.96e-43 | 1.16e+00 | -0.1207 |
5859 | QARS1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.71e-32 | 1.02e+00 | -0.1526 |
5859 | QARS1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.01e-88 | 1.41e+00 | -0.1464 |
5859 | QARS1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.37e-47 | 9.46e-01 | -0.1001 |
5859 | QARS1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.20e-70 | 1.49e+00 | -0.059 |
5859 | QARS1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.22e-31 | 1.36e+00 | -0.1706 |
5859 | QARS1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.29e-27 | 9.21e-01 | -0.2061 |
5859 | QARS1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.31e-28 | 1.28e+00 | -0.1462 |
5859 | QARS1 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.73e-36 | 1.26e+00 | -0.0842 |
5859 | QARS1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 9.29e-21 | 1.31e+00 | -0.00410000000000005 |
5859 | QARS1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.78e-35 | 1.08e+00 | -0.0179 |
5859 | QARS1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.03e-88 | 1.63e+00 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0010563 | Colorectum | AD | negative regulation of phosphorus metabolic process | 130/3918 | 442/18723 | 1.26e-05 | 2.76e-04 | 130 |
GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
GO:0045936 | Colorectum | AD | negative regulation of phosphate metabolic process | 129/3918 | 441/18723 | 1.81e-05 | 3.76e-04 | 129 |
GO:0051348 | Colorectum | AD | negative regulation of transferase activity | 85/3918 | 268/18723 | 2.07e-05 | 4.19e-04 | 85 |
GO:0042326 | Colorectum | AD | negative regulation of phosphorylation | 112/3918 | 385/18723 | 8.02e-05 | 1.27e-03 | 112 |
GO:0001933 | Colorectum | AD | negative regulation of protein phosphorylation | 101/3918 | 342/18723 | 9.39e-05 | 1.42e-03 | 101 |
GO:0006418 | Colorectum | AD | tRNA aminoacylation for protein translation | 19/3918 | 41/18723 | 2.37e-04 | 3.03e-03 | 19 |
GO:0043409 | Colorectum | AD | negative regulation of MAPK cascade | 57/3918 | 180/18723 | 4.61e-04 | 5.14e-03 | 57 |
GO:0051403 | Colorectum | AD | stress-activated MAPK cascade | 72/3918 | 239/18723 | 4.77e-04 | 5.25e-03 | 72 |
GO:0031098 | Colorectum | AD | stress-activated protein kinase signaling cascade | 74/3918 | 247/18723 | 4.80e-04 | 5.27e-03 | 74 |
GO:0006469 | Colorectum | AD | negative regulation of protein kinase activity | 65/3918 | 212/18723 | 5.21e-04 | 5.62e-03 | 65 |
GO:0033673 | Colorectum | AD | negative regulation of kinase activity | 71/3918 | 237/18723 | 6.18e-04 | 6.47e-03 | 71 |
GO:0043039 | Colorectum | AD | tRNA aminoacylation | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
GO:0043038 | Colorectum | AD | amino acid activation | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:0070302 | Colorectum | AD | regulation of stress-activated protein kinase signaling cascade | 58/3918 | 195/18723 | 2.21e-03 | 1.74e-02 | 58 |
GO:0032872 | Colorectum | AD | regulation of stress-activated MAPK cascade | 57/3918 | 192/18723 | 2.51e-03 | 1.92e-02 | 57 |
GO:0032873 | Colorectum | AD | negative regulation of stress-activated MAPK cascade | 19/3918 | 51/18723 | 5.44e-03 | 3.55e-02 | 19 |
GO:0070303 | Colorectum | AD | negative regulation of stress-activated protein kinase signaling cascade | 19/3918 | 51/18723 | 5.44e-03 | 3.55e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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