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Gene: PRR14L |
Gene summary for PRR14L |
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Gene information | Species | Human | Gene symbol | PRR14L | Gene ID | 253143 |
Gene name | proline rich 14 like | |
Gene Alias | C22orf30 | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q5THK1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
253143 | PRR14L | LZE2T | Human | Esophagus | ESCC | 3.27e-05 | 3.97e-01 | 0.082 |
253143 | PRR14L | LZE4T | Human | Esophagus | ESCC | 6.63e-10 | 2.81e-01 | 0.0811 |
253143 | PRR14L | LZE7T | Human | Esophagus | ESCC | 1.52e-07 | 3.33e-01 | 0.0667 |
253143 | PRR14L | LZE8T | Human | Esophagus | ESCC | 5.89e-04 | 1.83e-01 | 0.067 |
253143 | PRR14L | LZE22T | Human | Esophagus | ESCC | 8.58e-04 | 2.63e-01 | 0.068 |
253143 | PRR14L | LZE24D1 | Human | Esophagus | HGIN | 4.10e-02 | 5.67e-01 | 0.054 |
253143 | PRR14L | LZE24T | Human | Esophagus | ESCC | 3.32e-12 | 3.37e-01 | 0.0596 |
253143 | PRR14L | LZE21T | Human | Esophagus | ESCC | 1.83e-03 | 2.59e-01 | 0.0655 |
253143 | PRR14L | P1T-E | Human | Esophagus | ESCC | 5.80e-24 | 5.82e-01 | 0.0875 |
253143 | PRR14L | P2T-E | Human | Esophagus | ESCC | 9.74e-22 | 3.89e-01 | 0.1177 |
253143 | PRR14L | P4T-E | Human | Esophagus | ESCC | 3.96e-08 | 1.39e-01 | 0.1323 |
253143 | PRR14L | P8T-E | Human | Esophagus | ESCC | 5.00e-17 | 2.90e-01 | 0.0889 |
253143 | PRR14L | P9T-E | Human | Esophagus | ESCC | 2.13e-19 | 2.54e-01 | 0.1131 |
253143 | PRR14L | P10T-E | Human | Esophagus | ESCC | 4.16e-22 | 3.76e-01 | 0.116 |
253143 | PRR14L | P11T-E | Human | Esophagus | ESCC | 1.68e-09 | 3.45e-01 | 0.1426 |
253143 | PRR14L | P12T-E | Human | Esophagus | ESCC | 9.74e-22 | 3.06e-01 | 0.1122 |
253143 | PRR14L | P15T-E | Human | Esophagus | ESCC | 1.45e-20 | 4.17e-01 | 0.1149 |
253143 | PRR14L | P16T-E | Human | Esophagus | ESCC | 7.52e-23 | 3.46e-01 | 0.1153 |
253143 | PRR14L | P17T-E | Human | Esophagus | ESCC | 5.89e-12 | 3.84e-01 | 0.1278 |
253143 | PRR14L | P19T-E | Human | Esophagus | ESCC | 4.78e-02 | 2.32e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRR14L | SNV | Missense_Mutation | rs775406287 | c.5524N>C | p.Ser1842Pro | p.S1842P | Q5THK1 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD |
PRR14L | SNV | Missense_Mutation | rs775406287 | c.5524N>C | p.Ser1842Pro | p.S1842P | Q5THK1 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD |
PRR14L | SNV | Missense_Mutation | rs775406287 | c.5524N>C | p.Ser1842Pro | p.S1842P | Q5THK1 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-A8-A06R-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PRR14L | SNV | Missense_Mutation | rs781464777 | c.1279C>T | p.Arg427Cys | p.R427C | Q5THK1 | protein_coding | tolerated(0.12) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRR14L | SNV | Missense_Mutation | rs775406287 | c.5524T>C | p.Ser1842Pro | p.S1842P | Q5THK1 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PRR14L | SNV | Missense_Mutation | c.2005N>A | p.Asp669Asn | p.D669N | Q5THK1 | protein_coding | tolerated(0.12) | benign(0.011) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | |
PRR14L | SNV | Missense_Mutation | rs775406287 | c.5524N>C | p.Ser1842Pro | p.S1842P | Q5THK1 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AR-A1AY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Doxorubicin | SD |
PRR14L | SNV | Missense_Mutation | rs775406287 | c.5524N>C | p.Ser1842Pro | p.S1842P | Q5THK1 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PRR14L | SNV | Missense_Mutation | rs775406287 | c.5524N>C | p.Ser1842Pro | p.S1842P | Q5THK1 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-BH-A0HU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
PRR14L | SNV | Missense_Mutation | c.1099G>A | p.Gly367Ser | p.G367S | Q5THK1 | protein_coding | tolerated(0.33) | benign(0.009) | TCGA-BH-A1F0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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