TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
POU6F1 | BAS | Cervix | ADJ | CGA,C7orf31,AL136456.1, etc. | 1.82e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
POU6F1 | KER | Cervix | HSIL_HPV | CGA,C7orf31,AL136456.1, etc. | 3.73e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_HSIL_HPV/regulons_activity_in_dotplot.png) |
POU6F1 | ECM | Cervix | HSIL_HPV | MAFB,SLC25A34,ETV2, etc. | 4.21e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Cervix/Str/TF_HSIL_HPV/regulons_activity_in_dotplot.png) |
POU6F1 | DC | Colorectum | MSS | LBH,ZNF460-AS1,TCEANC, etc. | 5.75e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSS/regulons_activity_in_dotplot.png) |
POU6F1 | CD8TCM | Colorectum | MSS | LBH,ZNF460-AS1,TCEANC, etc. | 9.79e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSS/regulons_activity_in_dotplot.png) |
POU6F1 | TREG | Colorectum | SER | LBH,ZNF460-AS1,TCEANC, etc. | 6.25e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_SER/regulons_activity_in_dotplot.png) |
POU6F1 | LYMEND | Colorectum | AD | USP11,MRNIP,CERS6, etc. | 6.60e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_AD/regulons_activity_in_dotplot.png) |
POU6F1 | VFIB | Colorectum | MSI-H | USP11,MRNIP,CERS6, etc. | 3.42e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_MSI-H/regulons_activity_in_dotplot.png) |
POU6F1 | CD8TEX | Endometrium | AEH | MCM3AP,SPRY1,EGFL7, etc. | 2.56e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
POU6F1 | TH1 | Endometrium | AEH | MCM3AP,SPRY1,EGFL7, etc. | 2.85e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_AEH/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POU6F1 | SNV | Missense_Mutation | rs750427568 | c.1634G>A | p.Arg545His | p.R545H | | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-A2-A0YM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POU6F1 | SNV | Missense_Mutation | rs759527012 | c.1207N>A | p.Val403Met | p.V403M | | protein_coding | deleterious(0.05) | benign(0) | TCGA-AR-A0TV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POU6F1 | SNV | Missense_Mutation | novel | c.721N>A | p.Gln241Lys | p.Q241K | | protein_coding | tolerated(0.07) | unknown(0) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POU6F1 | SNV | Missense_Mutation | novel | c.1690N>A | p.Glu564Lys | p.E564K | | protein_coding | tolerated(0.09) | benign(0) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POU6F1 | SNV | Missense_Mutation | novel | c.1564G>T | p.Ala522Ser | p.A522S | | protein_coding | deleterious(0) | possibly_damaging(0.84) | TCGA-EK-A2RM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
POU6F1 | SNV | Missense_Mutation | novel | c.1690N>C | p.Glu564Gln | p.E564Q | | protein_coding | deleterious(0.02) | benign(0.022) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
POU6F1 | SNV | Missense_Mutation | rs777269426 | c.1574N>A | p.Arg525Gln | p.R525Q | | protein_coding | tolerated(0.06) | benign(0.044) | TCGA-VS-A9UB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
POU6F1 | SNV | Missense_Mutation | rs771763739 | c.1793N>T | p.Thr598Met | p.T598M | | protein_coding | deleterious(0.01) | possibly_damaging(0.609) | TCGA-VS-A9V3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
POU6F1 | SNV | Missense_Mutation | novel | c.1354N>C | p.Ile452Leu | p.I452L | | protein_coding | deleterious(0.02) | benign(0.024) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
POU6F1 | SNV | Missense_Mutation | rs139629485 | c.1249N>A | p.Ala417Thr | p.A417T | | protein_coding | tolerated(0.34) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |