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Gene: POMZP3 |
Gene summary for POMZP3 |
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Gene information | Species | Human | Gene symbol | POMZP3 | Gene ID | 22932 |
Gene name | POM121 and ZP3 fusion | |
Gene Alias | POM-ZP3 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q6PJE2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22932 | POMZP3 | LZE4T | Human | Esophagus | ESCC | 7.75e-03 | 1.07e-01 | 0.0811 |
22932 | POMZP3 | LZE22T | Human | Esophagus | ESCC | 5.03e-06 | 4.06e-01 | 0.068 |
22932 | POMZP3 | LZE24T | Human | Esophagus | ESCC | 5.73e-12 | 2.18e-01 | 0.0596 |
22932 | POMZP3 | P1T-E | Human | Esophagus | ESCC | 9.41e-07 | 3.13e-01 | 0.0875 |
22932 | POMZP3 | P2T-E | Human | Esophagus | ESCC | 1.57e-09 | 1.65e-01 | 0.1177 |
22932 | POMZP3 | P4T-E | Human | Esophagus | ESCC | 3.93e-16 | 3.74e-01 | 0.1323 |
22932 | POMZP3 | P5T-E | Human | Esophagus | ESCC | 2.82e-09 | 1.68e-01 | 0.1327 |
22932 | POMZP3 | P8T-E | Human | Esophagus | ESCC | 6.57e-05 | 9.36e-02 | 0.0889 |
22932 | POMZP3 | P9T-E | Human | Esophagus | ESCC | 7.12e-14 | 2.73e-01 | 0.1131 |
22932 | POMZP3 | P10T-E | Human | Esophagus | ESCC | 2.61e-17 | 2.99e-01 | 0.116 |
22932 | POMZP3 | P11T-E | Human | Esophagus | ESCC | 1.11e-13 | 7.82e-01 | 0.1426 |
22932 | POMZP3 | P12T-E | Human | Esophagus | ESCC | 3.06e-35 | 6.23e-01 | 0.1122 |
22932 | POMZP3 | P15T-E | Human | Esophagus | ESCC | 5.57e-26 | 3.99e-01 | 0.1149 |
22932 | POMZP3 | P16T-E | Human | Esophagus | ESCC | 5.13e-61 | 1.13e+00 | 0.1153 |
22932 | POMZP3 | P17T-E | Human | Esophagus | ESCC | 8.11e-19 | 5.25e-01 | 0.1278 |
22932 | POMZP3 | P20T-E | Human | Esophagus | ESCC | 2.40e-24 | 7.30e-01 | 0.1124 |
22932 | POMZP3 | P22T-E | Human | Esophagus | ESCC | 6.68e-16 | 3.22e-01 | 0.1236 |
22932 | POMZP3 | P23T-E | Human | Esophagus | ESCC | 3.51e-14 | 2.14e-01 | 0.108 |
22932 | POMZP3 | P24T-E | Human | Esophagus | ESCC | 1.47e-20 | 3.90e-01 | 0.1287 |
22932 | POMZP3 | P26T-E | Human | Esophagus | ESCC | 9.66e-05 | 1.68e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POMZP3 | SNV | Missense_Mutation | novel | c.326C>T | p.Ala109Val | p.A109V | Q6PJE2 | protein_coding | tolerated_low_confidence(0.38) | benign(0.408) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POMZP3 | SNV | Missense_Mutation | rs762361424 | c.31G>A | p.Ala11Thr | p.A11T | Q6PJE2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.821) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
POMZP3 | SNV | Missense_Mutation | c.187N>A | p.Glu63Lys | p.E63K | Q6PJE2 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.636) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
POMZP3 | SNV | Missense_Mutation | novel | c.50N>G | p.Phe17Cys | p.F17C | Q6PJE2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.192) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
POMZP3 | SNV | Missense_Mutation | novel | c.424N>G | p.Lys142Glu | p.K142E | Q6PJE2 | protein_coding | deleterious_low_confidence(0.04) | benign(0.376) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POMZP3 | SNV | Missense_Mutation | novel | c.4G>A | p.Val2Met | p.V2M | Q6PJE2 | protein_coding | deleterious_low_confidence(0) | benign(0.354) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POMZP3 | SNV | Missense_Mutation | c.100N>A | p.Pro34Thr | p.P34T | Q6PJE2 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.908) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
POMZP3 | SNV | Missense_Mutation | novel | c.317N>A | p.Phe106Tyr | p.F106Y | Q6PJE2 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.998) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POMZP3 | SNV | Missense_Mutation | novel | c.333N>A | p.Asp111Glu | p.D111E | Q6PJE2 | protein_coding | tolerated_low_confidence(0.16) | possibly_damaging(0.859) | TCGA-55-A493-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POMZP3 | SNV | Missense_Mutation | c.17N>C | p.Val6Ala | p.V6A | Q6PJE2 | protein_coding | tolerated_low_confidence(0.09) | benign(0.015) | TCGA-97-A4M5-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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