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Gene: OFD1 |
Gene summary for OFD1 |
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Gene information | Species | Human | Gene symbol | OFD1 | Gene ID | 8481 |
Gene name | OFD1 centriole and centriolar satellite protein | |
Gene Alias | 71-7A | |
Cytomap | Xp22.2 | |
Gene Type | protein-coding | GO ID | GO:0003341 | UniProtAcc | O75665 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8481 | OFD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.16e-04 | 2.41e-01 | -0.1954 |
8481 | OFD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.53e-02 | -2.01e-01 | -0.1464 |
8481 | OFD1 | A015-C-203 | Human | Colorectum | FAP | 6.76e-13 | 2.05e-01 | -0.1294 |
8481 | OFD1 | A015-C-204 | Human | Colorectum | FAP | 4.25e-02 | 2.36e-01 | -0.0228 |
8481 | OFD1 | A002-C-201 | Human | Colorectum | FAP | 1.89e-04 | 1.40e-01 | 0.0324 |
8481 | OFD1 | A001-C-108 | Human | Colorectum | FAP | 3.24e-08 | 2.48e-01 | -0.0272 |
8481 | OFD1 | A002-C-021 | Human | Colorectum | FAP | 1.47e-08 | 4.56e-01 | 0.1171 |
8481 | OFD1 | A002-C-205 | Human | Colorectum | FAP | 8.24e-25 | 5.53e-01 | -0.1236 |
8481 | OFD1 | A014-C-108 | Human | Colorectum | FAP | 6.35e-03 | 3.52e-01 | -0.124 |
8481 | OFD1 | A001-C-104 | Human | Colorectum | FAP | 2.54e-02 | 2.72e-01 | 0.0184 |
8481 | OFD1 | A015-C-006 | Human | Colorectum | FAP | 1.32e-08 | 2.48e-01 | -0.0994 |
8481 | OFD1 | A015-C-106 | Human | Colorectum | FAP | 4.92e-06 | 3.00e-01 | -0.0511 |
8481 | OFD1 | A002-C-114 | Human | Colorectum | FAP | 5.42e-08 | 1.44e-01 | -0.1561 |
8481 | OFD1 | A015-C-104 | Human | Colorectum | FAP | 5.20e-24 | 4.17e-01 | -0.1899 |
8481 | OFD1 | A015-C-202 | Human | Colorectum | FAP | 3.46e-07 | 3.45e-01 | -0.0849 |
8481 | OFD1 | A001-C-014 | Human | Colorectum | FAP | 4.79e-05 | 2.07e-01 | 0.0135 |
8481 | OFD1 | A002-C-016 | Human | Colorectum | FAP | 2.31e-09 | 2.30e-01 | 0.0521 |
8481 | OFD1 | A015-C-002 | Human | Colorectum | FAP | 3.40e-06 | 2.95e-01 | -0.0763 |
8481 | OFD1 | A001-C-007 | Human | Colorectum | CRC | 7.15e-04 | 4.63e-01 | 0.1899 |
8481 | OFD1 | A001-C-203 | Human | Colorectum | FAP | 1.21e-02 | 2.50e-01 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
GO:0099111 | Lung | IAC | microtubule-based transport | 35/2061 | 190/18723 | 1.55e-03 | 1.64e-02 | 35 |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
GO:00991113 | Oral cavity | OSCC | microtubule-based transport | 96/7305 | 190/18723 | 7.92e-04 | 4.27e-03 | 96 |
GO:009911111 | Oral cavity | NEOLP | microtubule-based transport | 34/2005 | 190/18723 | 1.87e-03 | 1.28e-02 | 34 |
GO:00991112 | Prostate | BPH | microtubule-based transport | 49/3107 | 190/18723 | 8.05e-04 | 5.27e-03 | 49 |
GO:00991111 | Prostate | Tumor | microtubule-based transport | 51/3246 | 190/18723 | 6.62e-04 | 4.68e-03 | 51 |
GO:00991115 | Thyroid | PTC | microtubule-based transport | 88/5968 | 190/18723 | 2.08e-05 | 2.08e-04 | 88 |
GO:009911112 | Thyroid | ATC | microtubule-based transport | 91/6293 | 190/18723 | 2.97e-05 | 2.48e-04 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OFD1 | SNV | Missense_Mutation | c.2006N>A | p.Ser669Asn | p.S669N | O75665 | protein_coding | tolerated(0.12) | benign(0.031) | TCGA-A2-A0YT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD | |
OFD1 | SNV | Missense_Mutation | c.2680G>C | p.Glu894Gln | p.E894Q | O75665 | protein_coding | deleterious(0.02) | benign(0.26) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
OFD1 | SNV | Missense_Mutation | c.1508G>T | p.Cys503Phe | p.C503F | O75665 | protein_coding | deleterious(0.03) | benign(0.124) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
OFD1 | SNV | Missense_Mutation | c.1960N>G | p.Arg654Gly | p.R654G | O75665 | protein_coding | deleterious(0.03) | benign(0.365) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
OFD1 | SNV | Missense_Mutation | c.2522G>T | p.Gly841Val | p.G841V | O75665 | protein_coding | deleterious(0) | benign(0.134) | TCGA-BH-A202-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
OFD1 | SNV | Missense_Mutation | c.625N>C | p.Glu209Gln | p.E209Q | O75665 | protein_coding | tolerated(1) | benign(0.019) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OFD1 | SNV | Missense_Mutation | c.2898N>T | p.Gln966His | p.Q966H | O75665 | protein_coding | deleterious(0) | possibly_damaging(0.906) | TCGA-E2-A1IL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
OFD1 | insertion | Nonsense_Mutation | novel | c.1489_1490insTCAGCCATTTTTATCTTACCTTTCATATTTAAAAAAT | p.His497LeufsTer11 | p.H497Lfs*11 | O75665 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
OFD1 | insertion | Frame_Shift_Ins | novel | c.2123_2124insTTGTTTGTTTTGTTTTGTTTTTAAGACAC | p.Glu708AspfsTer20 | p.E708Dfs*20 | O75665 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
OFD1 | insertion | Nonsense_Mutation | novel | c.1384_1385insATATATTTT | p.Arg462delinsAsnIlePheTer | p.R462delinsNIF* | O75665 | protein_coding | TCGA-BH-A0BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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